RENIN ACTIVITY, PLASMA

​Performing Laboratory: Mayo Clinic Laboratories, Rochester

​2 tubes of 3 mL EDTA blood

Draw blood from the patient in a seated position.

Collect blood directly into a chilled EDTA tube and immediately keep cold in ice.

​Keep cold with ice and send immediately to the laboratory.

​Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Mayo Clinic Laboratories Reference Interval:

0 - 2 years: 4.6 ng/mL/hour (mean)* Range: 1.4-7.8 ng/mL/hour
3 - 5 years: 2.5 ng/mL/hour (mean)* Range: 1.5-3.5 ng/mL/hour
6 - 8 years: 1.4 ng/mL/hour (mean)* Range: 0.8-2.0 ng/mL/hour
9 - 11 years: 1.9 ng/mL/hour (mean)* Range: 0.9-2.9 ng/mL/hour
12 - 17 years: 1.8 ng/mL/hour (mean)* Range: 1.2-2.4 ng/mL/hour
Mean data not standardized as to time of day or diet.
Infants were supine, children sitting.

*Reference: Stalker HP, Holland NH, Kotchen JM, Kotchen TA: Plasma renin activity in healthy children. J Pediatr 1976;89:256-258
 
Peripheral vein specimen
Na-deplete, upright
18 - 39 years:
10.8 ng/mL/hour (mean)
2.9 - 24.0 ng/mL/hour (range)

≥ 40 years:
5.9 ng/mL/hour (mean)
2.9 - 10.8 ng/mL/hour (range)
 
Na-replete, upright
18 - 39 years:
1.9 ng/mL/hour (mean)
≤ 0.6 - 4.3 ng/mL/hour (range)

≥ 40 years:
1.0 ng/mL/hour (mean)
≤ 0.6 - 3.0 ng/mL/hour (range)

​Up to 9 working days

​This test is sent out to Mayo Clinic Laboratories for testing.

Mayo Clinic Renin Activity, Plasma

Patient preparation:

The plasma renin activity cannot be interpreted if the patient is treated with spironolactone (Aldactone).

Spironolactone should be discontinued for 4 to 6 weeks before testing.