ITRACONAZOLES, SERUM

​3 mL plain blood in red top tube (no gel)

Blood sample should be taken just before the next dose for assessment of trough level.

​High Performance Liquid Chromatography

​Therapeutic Range:
Suggested total trough level
(Itraconazole + Hydroxy-Itraconazole): > 1.5 mg/L
(Clin Infect Dis 2016; 63: e1 - 60)

​Mean = 3 days, Range: 2 - 5 days

​Tuesday and Friday

Measured Parameters: Itraconazole, Hydroxy-Itraconazole

Reported Parameters: Itraconazole, Hydroxy-Itraconazole, Total Itraconazole

Total Itraconazole is calculated from the sum of Itraconazole and Hydroxy-Itraconazole.

Patient Preparation:

Patient should abstain from the following at least 3 days prior to and during blood sample collection:
- where medically possible, drugs such as Amprevavir, Valsartan.

The list of drugs have been selected on the basis of potential significance to test measurement and are not necessarily all-inclusive.

Please contact the Clinical Biochemistry Laboratory for assistance if necessary.