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Information on COVID-19 and vaccination

Summary of Recommendations for COVID-19 Vaccination in patients with Rheumatological conditions

Am I suitable to receive the vaccine?

Is it safe to get vaccinated?


I have a rheumatological disease e.g. rheumatoid arthritis, SLE, psoriatic arthritis, vasculitis


All patients with these conditions are encouraged to receive the COVID-19 vaccine

However, if your condition is not controlled, or you are unsure about this, please contact your primary Rheumatologist

I am on immunosuppressive drugs for my rheumatological condition e.g. methotrexate, sulfasalazine, mycophenolate mofetil, prednisolone etc.


Persons on oral and injection forms of immunosuppressive drugs can be vaccinated (except for rituximab that needs special consideration).


I am on rituximab or had rituximab in the last 6 months

Please contact your primary rheumatologist to discuss if you should have the vaccine

I have a history of allergy to drugs, food, insect stings or unknown trigger NOT amounting to anaphylaxis**


Persons with multiple allergies NOT amounting to anaphylaxis** CAN be vaccinated

I have a history of allergic reactions to other vaccines


Please speak to your primary Rheumatologist

I have a history of severe drug reactions e.g. Stevens-Johnson-Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), Drug Rash with Eosinophilia and Systemic Symptoms (DRESS), Drug-induced Hypersensitivity Syndrome (DiHS)


This guideline has been recently updated by MOH dated 31 May 2021 (MOH Circular No. 66/2021)

I have a history of anaphylaxis** to drugs, food, insect stings or unknown trigger


Please speak to your primary Rheumatologist

​I have been prescribed an Epi-Pen (current or in the past) ​NoPlease speak to your primary Rheumatologist as this suggests anaphylaxis** risk

** Anaphylaxis is a life-threatening allergic reaction with two or more of the following three criteria:

  • Hives or face/eyelid/lip/throat swelling     
  • Difficulty breathing or
  • Dizziness

Please refer to the Patient Information Sheet for more detailed information on the COVID-19 vaccines in patients with rheumatological conditions. [PDF|560KB]

Version 2: 1 June 2021 (based on MOH circular No. 66/2021)

Prepared by Dr Yeo Siaw Ing and Dr Ng Chin Teck, Senior consultants, Rheumatology and Immunology, SGH

Approved by Dr Andrea Low, Head, Rheumatology and Immunology, SGH