This assay detects 18 mutations in codons 12, 13, 61, 117 and 146 of the KRAS gene and V600E in exon 15 of the BRAF gene. The presence of these mutations correlates with a lack of response to certain EGFR inhibitor cancer therapies in metastatic colorectal cancer patients.
Paraffin embedded tissue block sent to the Histopathology Section. Alternatively, unstained slides can be sent to the Histopathology Section. Note : - At least 8 sections of 8 mm thickness, or 12 sections of 5 mm thickness for smaller biopsies should be sent together with one H&E slide, 4 mm thick with a coverslip as a reference slide. - Tumour content must be indicated and must be at least 30%.
EntroGen KRAS/BRAF Mutation Analysis Kit (v1.2), using allele-specific real-time PCR.
Detected, Not Detected or Inconclusive
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