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CYTOMEGALOVIRUS (CMV) ANTIBODY

Synonym(s):

​CMV IgG Antibody, CMV IgG, CMV IgM Antibody, CMV IgM, CMV CFT (blood), CMV Total Antibody (blood)

Lab Section Category

Description

​Cytomegalovirus IgM Antibody (anti-CMV IgM)

Cytomegalovirus IgG Antibody (anti-CMV IgG) 

Cytomegalovirus CF Total Antibody (anti-CMV total)

Indications

Specimen Required

​3 – 5 mL plain blood.

(a) To diagnose acute infection, send acute sample for CMV IgM Antibody and second serum taken 14 days later for CMV CF Total Antibody on the pair.

(b) To diagnose previous infection, send single sample for CMV IgG Antibody.

Storage and Transport

​Refrigerate samples if delay in transporting to laboratory is anticipated. Do not freeze.

Method

​Anti-CMV IgM : Enzyme Immunoassay

Anti-CMV IgG : Chemiluminescent Microplate Immunoassay

Anti-CMV total : Complement Fixation Test (CFT)

Test Results

Acute infection: IgM Ab positive and/or paired sera showing ≥ 4 fold rise of CF Ab titres. Single sample having CF Ab titre ≥ 128 is suggestive of a recent infection. Confirm by virus isolation.

Previous (latent) infection: CMV IgG present.

Reference Interval / Value

Turnaround Time

​Anti-CMV IgM : <1 – 7 days (Negative report)
                           <1 – 14 days (Positive / Equivocal report)

Anti-CMV IgG : <1 – 4 days

Anti-CMV total : 1 – 6 days

Day(s) Test Set up

​Anti-CMV IgM : Monday

Anti-CMV IgG : Tuesday and Friday

Anti-CMV total : Tuesday and Thursday

Remarks

Change History Notes

Others

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