Ultrasound of the pelvis is useful to demonstrate whether there is any abnormality (e.g. thickening) of the endometrium. However, to diagnose endometrial cancer, an endometrial biopsy is necessary. This can be achieved via outpatient aspiration of endometrial contents (e.g. pipelle or Explora endometrial sampling devices) or as a minor day surgical procedure called dilatation and curettage with hysteroscopy. Specimens of the endometrial biopsy are sent for microscopic analysis.