Psoriatic Arthritis - Research | Singapore General Hospital

Although there is currently no cure for PsA, it is a treatable disease. This has relied on advances in research that has made a difference to the lives of patients with PsA. However, we still have a long way to go in understanding the disease.

We need to identify the cause and triggers of PsA, how to detect PsA in its early stages and consequently how the disease behaves (e.g. some patients have a very mild and stable spectrum, others have more severe and rapidly worsening spectrum), and how we can better target treatment to bring precision medicine to patients. This means optimising the benefits of treatment whilst minimising the side-effects of medication for the individual person. Research is therefore necessary to continue to discover new treatments and improve the care of patients with PsA.

We hope to make a difference in the lives of patients through research. The clinician researchers and scientists at SGH lead a nation-wide PsA research network and have built a database to allow analysis of clinical data, as well as blood and other tissue samples from patients who have chosen to participate. The team lead and collaborate with renowned local and international academic institutions, and industry to accelerate discoveries and uncover new cures for PsA.

About Research Focus Area

Understanding the cause and triggers of PsA
Early diagnosis of PsA for better outcomes
Discovery of new treatments for PsA

Top 10 publications in Psoriatic Arthritis

Leung, Y.-Y., et al., Management of Peripheral Arthritis in Patients With Psoriatic Arthritis: An Updated Literature Review Informing the 2021 GRAPPA Treatment Recommendations. The Journal of Rheumatology, 2023. 50(1): p. 119-130. https://dx.doi.org/10.3899/jrheum.220315
Tarannum, S., et al., Sex- and gender-related differences in psoriatic arthritis. Nature Reviews Rheumatology, 2022. 18(9): p. 513-526. https://dx.doi.org/10.1038/s41584-022-00810-7
Lucasson, F., et al., Disparities in healthcare in psoriatic arthritis: an analysis of 439 patients from 13 countries. RMD Open, 2022. 8(1). https://dx.doi.org/10.1136/rmdopen-2021-002031
Leung, Y.Y., et al., Comparing the Patient-Reported Physical Function Outcome Measures in a Real-Life International Cohort of Patients With Psoriatic Arthritis. Arthritis Care Res (Hoboken), 2021. 73(4): p. 593-602. https://dx.doi.org/10.1002/acr.24139
FitzGerald, O., et al., Psoriatic arthritis. Nature Reviews Disease Primers, 2021. 7(1): p. 1-17. http://doi.org/10.1038/s41572-021-00293-y
Coates, L.C., et al., What influences patients' opinion of remission and low disease activity in psoriatic arthritis? Principal component analysis of an international study of 424 patients. Rheumatology (Oxford), 2021. http://doi.org/10.1093/rheumatology/keab220
Orbai, A.M., et al., International patient and physician consensus on a psoriatic arthritis core outcome set for clinical trials. Ann Rheum Dis, 2017. 76(4): p. 673-680. https://dx.doi.org/10.1136/annrheumdis-2016-210242
Leung, Y.Y., et al., OMERACT Filter 2.1 instrument selection for physical function domain in psoriatic arthritis: Provisional endorsement for HAQ-DI and SF-36 PF. Semin Arthritis Rheum, 2021. 51(5): p. 1117-1124. https://dx.doi.org/10.1016/j.semarthrit.2021.07.014
Liu, V., et al., Residual Disease Burden in Patients With Axial Spondyloarthritis and Psoriatic Arthritis Despite Low Disease Activity States in a Multiethnic Asian Population. J Rheumatol, 2021. 48(5): p. 677-684. https://dx.doi.org/10.3899/jrheum.200934
Coates, L.C., et al., Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021. Nature Reviews Rheumatology, 2022. https://dx.doi.org/10.1038/s41584-022-00798-0

Research in Psoriatic Arthritis

About Research Focus Area

Top 10 publications in Psoriatic Arthritis