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Home Research & Innovation Enablers Radiological Sciences

Radiological Sciences

Synonym(s):

Pioneering Medical Imaging Through Research Excellence

Radiological Sciences enablers provide comprehensive technical expertise and research support through advanced imaging technologies and innovative methodologies. Our capabilities span from sophisticated imaging techniques to artificial intelligence applications, supporting both clinical care and research initiatives at Singapore General Hospital.

Core Capabilities

Our expertise spans 6 key project areas:

1. Artificial Intelligence Research and Deep Learning for Images

  • Python de-identification script & Python facial de-identification script to ensure data confidentiality
  • Radiological labeling/annotating of research images, stored on an open-source research PACS with XNAT
  • Ground truth marking for supervised learning for AI

2. Advanced Magnetic Resonance Imaging Research; Molecular Imaging Research

Techniques we are proficient in include the following (non-exhaustive):

MRI-based

  • Dynamic Contrast Enhanced (DCE) MRI Perfusion Imaging for angiogenesis
  • Diffusion Imaging (diffusion weighted; diffusion tensor; diffusion kurtosis) for tissue cellularity and fibrosis, and brain microstructural integrity
  • Quantitative Susceptibility Imaging for iron loading in neurodegeneration, hemorrhages and venous imaging
  • Blood Oxygen Dependent Imaging (BOLD) for task based and resting state functional MRI brain activation
  • Chemical Exchange Saturation Transfer (CEST) - Amide Proton Transfer (APT) for mobile proteins to characterise cellularity in malignancies
  • MR Spectroscopy for metabolic semi-quantification
  • Quantitative Susceptibility Mapping, Resting State MRI, Myelin Water Imaging for evaluation of brain dysmyelination in neurodegeneration such as Parkinson’s Disease, chemobrain and other neurological conditions

Radiotracer imaging

  • Positron emission tomography (PET) scanning in animals and humans for presence of molecular targets
  • Radiochemistry labeling of antibodies, proteins and small molecules to interrogate biology

3. Enabling Imaging-based Population Health & Health Services Research

  • Anchor and enable population health screening-related projects through the use of cost-effective radiological tools (e.g. lung cancer screening, breast cancer screening, brain volume screening)

4. Assist with Randomised Controlled Trials for Medical Devices & 3D Printing

  • Trialling and development of medical devices
  • Design and produce patient-specific 3D-printed anatomical models, surgical guides, appliances and implants for clinical care

5. Structuring Radiology Reports for Organised Data Collection

  • Provide tagged and structured radiology reports for data analytics
  • Clinical data can be prospectively entered into PACs reporting fields
  • This data can be sent from PACS to RIS, and subsequently from RIS to Sunrise and eHINTS

 

6. Assist with the Technical Aspects of Animal (Pre-clinical) Scanning at SingHealth Experimental Medicine Centre (SEMC) and A*STAR Institute of Bioengineering & Bioimaging (IBB)

 

 

Projects

Our department manages numerous grant-funded projects across various domains.

Academic Medicine Enterprise Projects:

  • AI-driven initiatives (iScreen, SUPER Registry)
  • Advanced imaging studies
  • Medical device development
  • Clinical trials and registries

Industry and External Projects:

  • AI and deep learning applications
  • Precision medicine initiatives
  • 3D printing innovations
  • Multi-centre clinical trials
  • Translational research programmes

Grant funded imaging projects:

No

Project Title

Funding Source / PI

1

SUPER- Skin lesion Ultrasound ProspectivE Registry for audit, research and machine learning

RADSC ACP Pitch for Funds Apr 2024

PI: Dr Dorinda Chew

2

Developing in-house AI Models for Radiograph classification (Limbs + Thorax)

Clinical & Systems Innovation support (ACP Prog Fund FY20 Cycle 2)

PI: Dr Mark Tan Bangwei

3

Industry 4.0 and Imaging (I4I) - Additive Manufacturing and AI in Imaging

FY21 cycle 2 ACP Programme Funding - Nurturing Clinician Researcher Scheme Mar 2021 (Clinician Innovator)

PI: Dr Mark Tan Bangwei

4

Test-bedding of iScreen - AI priority sorting system for brain scans for head injury patients

Academic Medicine Innovation Institute (AMII) Test Bedding and Adoption Grant FY23 Aug 2023

PI: Dr Sarat Kumar Sanamandra

5

Diagnostic performance of advanced ultrasound modalities in local assessment of skin tumors: comparison with histological assessment

SGH Research Grant Oct 2020 (New investigator)

PI: Kho Ying Ying

6

AUTOmatic ROBotic UltraSonography sysTem (AUTO ROBUST) for Routine Ultrasound Scanning of Bladder

SGH Innovation Grant (SIG) Call Oct 2022

PI: Dr Ooi Chin Chin

7

Brain Correlational Tractography of Cholinergic Pathways among Older Persons with Mild Cognitive Impairment: (CoCo)

SGH Research Grant Oct 2022 - Open category

PI: Dr Seow Poh Choo

8

Intra-arterial Computed Tomography (IACT) Phantom for Interventional Radiography Training

SGH Innovation Grant (SIG) April Call 2022

PI: Kenneth Yeo

9

Pre-operative Prostate Artery Embolisation for Transurethral resection of prostate in benign prostatic hyperplasia:  A randomised control study comparing two different size microsphere on blood loss

RADSC ACP Pitch for Fund Oct 2021

PI: Dr Alfred Tan

10

68Ga-Radiolabelled Triphenylphosphonium PET tracer for mitochondrial targeting neuroblastoma imaging

RADSC ACP Pitch for Funds Oct 2019

PI: Dr Yang Changtong

11

Overcoming Resistance to Radioactive Iodine (RAI) Therapy in RAI-Refractory Advanced Thyroid Carcinoma - Bench to Clinical Re-differentiation Trial applying a Novel Time-Dependent Concept

RADSC ACP Pitch for Funds Oct 2020

PI: A/Prof Kelvin Loke

12

68Ga-FAPI based PET/CT for imaging Systemic sclerosis-associated Interstitial Lung Disease (SSc-ILD)

SGH Research Grant Oct 2020 (Open)

PI: Dr Xie Wanying

13

Using Artificial Intelligence to Aid in Diagnosis of Ring Enhancing Brain Lesions

MED ACP Pitch for Funds

PI: Dr Edwin Sng (DEM, Infectious Diseases), co-Is: Prof Chan Ling Ling

 

No

Project Title

Funding Source / PI

1

RAPIER (Radiology Pathology Information Exchange Resource)

AI Singapore Tech Challenge (Open-Theme) Aug 2021

PI: Dr Liu Yong (IHPC A*STAR); Medical PI (Industry partner): A/Prof Lionel Cheng

2

Application of a Deep Learning Algorithm in Detection of Hardware Complications for the Post-Operative Hip

International Skeletal Society Early Career Grant Mar 2023

PI: Dr Tan Jin Rong

3

Evaluating the utility of large language models in the appropriateness assessment of musculoskeletal MRI requests: A comparative study

Singapore Radiological Society (SRS) Trust Fund Oct 2023

PI: Dr Tan Jin Rong

4

Precision Medicine on Head CT to Identify Neurodegeneration through Deep Learning-Based Segmentation Empowered with Brain MR Morphometry (PRECISE)

NMRC CSA (Senior Investigator) Nov 2020 Grant Call

PI: Prof Chan Ling Ling

5

iScreen - Image Processing Platform Empowering Radiology and Clinicians Through Artificial Intelligence

NHIC Innovation to Commercialisation Programme – I2I Aug 2021

PI: Prof Chan Ling Ling

6

3D Printed Surgical Implants at Point of Care

MOH Health Innovation (MHI) Fund 2024

PI: Dr Mark Tan Bangwei

7

The relationship between hepatic fat and whole body lipid metabolism during the immediate and early post-bariatric surgery period

NMRC Centre Grant

PI: Dr Tan Hong Chang (Dept of Endocrinology, SGH); co-Is: Dr Albert Low Su Chong, A/Prof Lionel Cheng

8

Decoding global gene expression in liver cancer through deep learning and standard-of-care clinical imaging

NHIC I2Start Grant

PI: Prof Pierce Chow (SURG ACP, NCCS); co-I: Dr Lim Kheng Choon

9

Precision Medicine in Systemic Sclerosis Gastrointestinal Disease: Evaluating Imaging and Stool Biomarkers for Differentiating Disease Stages and Treatment Responses

NMRC Clinician Scientist Award (Investigator)

PI: Dr Andrea Low (Dept of Rheumatology & Immunology, MED ACP, SGH); co-Is: Dr Xie Wanying, Dr Chan Wan Ying

10

Safety and efficacy of prostate artery embolization in patients with benign prostatic hyperplasia on concurrent antiplatelet or anticoagulant medication

Singapore Radiological Society (SRS) research grant Apr 2020

PI: Dr Sivanathan Chandramohan

11

Randomised clinical trial comparing drug-coated balloon to plain balloon for all peripheral AVF stenosis (Ranger RCT)

Boston Scientific Mar 2022

PI: Dr Zhuang Kun Da

12

A Multicenter Observational Registry to Develop Ablation Parameter Guidance for Microwave Liver Ablation of Soft Tissue Lesions

NeuWave Medical, Inc May 2022

PI: A/Prof Too Chow Wei

13

Translating Mesenchymal Stem Cell Exosomes into Pharmaceuticals (TEX2PHARM)

RIE 2020 Health and Biomedical Sciences (HBMS)  Industry Alignment Fund Pre-positioning (IAF-PP) Jul 2020

Team PIs: Prof David Ng, Dr Yang Changtong

 

 

Goals

We are committed to:

  • Advancing imaging technologies for improved diagnostics
  • Developing AI-driven solutions
  • Supporting translational research
  • Enhancing clinical trials through innovative methodologies
  • Expanding population health screening capabilities
  • Advancing 3D printing applications in healthcare
  • Fostering collaboration between clinical and research communities

 

 

Collaborate

Our research committee comprises experts across various specialties:

Name

RADSC ACP Appointment

Prof Chan Ling Ling

Academic Vice Chair, Research

Dr Tran Nguyen Tuan Anh

Director, Artificial Intelligence Research

Dr Sumeet Kumar

Director, Advanced Magnetic Resonance Imaging Research

A/Prof Kelvin Loke

Director, Molecular Imaging Research

A/Prof Too Chow Wei

Director, Population Health and Health Services Research

A/Prof Apoorva Gogna

Director, Clinical Trials and Medical Devices Research

Ms Azizah Binte Mohamed Afif

Director, Radiography & Nursing Research

Let's Connect!

 

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SGH Enablers

Health Services Research Unit (HSRU)

Optimizes healthcare delivery through evidence-based research and outcome studies

Clinical Innovation and Technology Unit (CITU)

Develops technological solutions to address clinical challenges in healthcare

Clinical Trials & Research Centre (CTRC)

Provides end-to-end support for clinical trials and research studies

Department of Clinical Translational Research (DCR)

Transforms laboratory discoveries into practical clinical treatments and applications

Biomechanics Lab

Studies movement science to improve patient rehabilitation and musculoskeletal care

Data Science and Artificial Intelligence Laboratory (DSAIL)

Applies AI and analytics to enhance healthcare delivery outcomes

Pathological Sciences

Advances disease diagnostics through innovative pathology research and methods

Radiological Sciences

Develops advanced imaging techniques for improved diagnosis and treatment

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