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Dr Francesca Lorraine Lim

Dr Lim Wei Inng Francesca Lorraine

MBBS, BSc, MMed(Int Med), MRCP(UK)

Senior Consultant

Specialty: Haematology

Sub-specialties: Haematopoietic Stem Cell & Cellular Therapy

Conditions Treated by this Doctor:
Acute Lymphocytic Leukemia (ALL), Aplastic Anaemia, Chronic lymphocytic leukemia, Chronic Myeloid Leukemia (CML), Deep Vein Thrombosis, Deep Vein Thrombosis, essential thrombocythemia, Lymphoma, Multiple Myeloma, Myelodysplastic Syndromes, Myelofibrosis, Polycythemia Vera, Thalassaemia.

Clinical Appointments

  • Senior Consultant SingHealth Duke-NUS Blood Cancer Centre
  • Senior Consultant SingHealth Duke-NUS Transplant Centre
  • Senior Consultant Haematology Singapore General HospitalSingapore General Hospital

Academic Appointments

  • Assistant Professor

Profile

Dr Lim is a Senior Consultant Hematologist at Singapore General Hospital and the Assistant Medical Director at the Cell Therapy Facility, Health Science Authority (HSA). Dr Lim is also the Principal Lead of Education and the Lead of Cellular Immunotherapy for adult blood cancers of the SingHealth Duke-NUS Cell Therapy Centre (SDCT). 

Dr Lim spent 2 years training at MD Anderson Cancer Center on CAR T cell therapy particularly on CAR NK cell therapy under Professor Katy Rezvani as well as in the Good Manufacturing Processing Facility (GMP). Since her return from MD Anderson Cancer Center, Dr Lim has been instrumental in supporting and coordinating the Cell Therapy Program at SGH Haematology, SingHealth, both at the clinical, research and translational level.

Education

  • ​MBBS, BSc (UK), UCL& RFC
  • MMed(Int Med), MRCP(UK), Royal College of Medicine

Professional Appointments and Committee Memberships

  • Assistant Professor, Duke-NUS Medical School
  • Deputy Medical Director at the Cell Therapy Facility, Health Science Authority (HSA)
  • Principal Lead, Education, Singhealth Duke NUS Cell Therapy Center 
  • Lead, Cellular Immunotherapy, Singhealth Duke NUS Cell Therapy Center 
  • Member, Singapore Society of Haematology

Awards

Research Interests

Publications

  • Proven and unproven cell therapies – what we have learned so far? Francesca.L.W.I.Lim. ISBT Science Series. April 2021; doi: 10.1111/voxs.12636
  • Cost-effectiveness and budget impact analyses of tisagenlecleucel in adult patients with relapsed or refractory diffuse large B cell lymphoma from Singapore’s private insurance payer’s perspective. Wang XJ, Wang YH, Li SCT, Gkitzia C, Lim ST, Koh LP, Lim FLWI, Hwang WYK.J Med Econ. 2021 Apr 27:1. doi: 10.1080/13696998.2021.1922066.
  • Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells. 
  • May Daher, Rafet Basar,…,Francesca Lorraine Wei Inng Lim…Katayoun Rezvani. Blood, The Journal of the American Society of Hematology 137 (5), 624-636, 2021.
  • Metabolic reprograming of GMP grade cord tissue derived mesenchymal stem cells enhances their suppressive potential in GVHD. Mayela Mendt, May Daher, Rafet Basar, Mayra Shanley…Francesca Lim Wei Inng… Richard Champlin, Elizabeth J. Shpall, Katayoun Rezvani. Frontiers in Immunology. (631353) 2021
  • AFM13-Targeted Blood and CORD-blood-derived memory-like NK cells as therapy for CD30+ malignancies. Lucial Kerbauy, Nancy Marin, Mecit Kaplan...Francesca Wei Inng Lim,…Richard Champlin, Elizabeth J. Shpall, Katayoun Rezvani. J ImmunotherCancer. Dec 2020; 8 (suppl 3): A1-A559.
  • CIS checkpoint deletion enhances the fitness of cord blood derived natural killer cells transduced with a chimeric antigen receptor. May Daher, Rafert Basar, Elif Gokdemir,…Francesca Lorraine Wei Inng Lim….Richard Champlin, Elizabeth J. Shpall, Katayoun Rezvani. bioRxiv. March 2020.  
  • Emerging CAR landscape for cancer immunotherapy. FLWI Lim, SO Ang. Biochemical Pharmacology. August 2020, 114051. 
  • Donor-type fresh frozen plasma is effective in preventing hemolytic reaction in major ABO incompatible allogeneic stem cell transplant. Quek J, Lee JJ, Lim FL, Diong C, Goh YT, Gopalakrishnan S, Ho A, Hwang W, Koh M, Loh Y, Linn YC. Transfusion. Jan 2019; 59 (1): 335-339
  • Mobilization kinetics of peripheral blood stem cells with rescue plerixafor – a real-world experience from a single center. Khaing Shwe Wah Pwint, Yunxin Chen, Colin Phipps Diong, Yeow-Tee Goh, Dixon Grant, Aloysius Ho, William Hwang, Sathish Kumar, Yuh-Shan Lee, Francesca Lim, Yvonne Loh, Chandramouli Nagarajan, Jeffrey Quek, Miriam Tao, Hein Than and Yeh-Ching Linn. Leukemia & Lymphoma. Feb 2020. DOI: 10.1080/10428194.2020.1731501
  • Low-dose insulin-like growth factor binding proteins 1 and 2 and angiopoietin-like protein 3 coordinatesly stimulate ex vivo expanaion of human umbilical cord blood hematopoietic stem cells as assayed in NOD/SCID gamma null mice. Fan X, Florence PH Gay, Francesca WI Lim….William YK Hwang. Stem Cell Res Ther. 2014.5(3): 71.
  • Cutaneous follicular hyperkeratotic spicules–the first clinical sign of multiple myeloma progression or relapse. LK Tay, FL Lim, HJ Ng, HY Lee, SM Pang, T Thirumoorthy. International journal of dermatology 2010. 49 (8), 934-936
  • Respiratory virus infection after allogeneic hematopoietic stem cell transplant in a tropical center: predictive value of the immunodeficiency scoring index. L Wang, J Allen, C Diong, YT Goh, S Gopalakrishnan, A Ho, W Hwang. Transplant Infectious Disease 19 (3), e12693
  • An exploration of the applicability of the refined disease risk index and its integration with other independent risk factors for individualized prognostication VV Maka, LP Koh, C Diong, YT Goh, S Gopalakrishnan, A Ho, W Hwang, Bone marrow transplantation 52 (3), 363-371
  • Use of defibrotide to treat transplant-associated thrombotic microangiopathy: a retrospective study of the Paediatric Diseases and Inborn Errors Working Parties of the European. L Yeates, MA Slatter, S Bonanomi, FLWI Lim, SY Ong, A Dalissier, Bone marrow transplantation 52 (5), 762-764
  • Exploring the Cord Blood T Cell Compartment with Mass Cytometry Reveals the Existence of Memory CD4, CD8 and Regulatory T Cell Pools in the Fetal Period. M Muftuoglu, L Li, J Jimenez, D Mak, JK Burks, B Hu, FLWI Lim, H Shaim, Blood 130 (Supplement 1), 4467-4467
  • Usefulness of an Immunodeficiency Scoring Index for predicting outcomes of respiratory virus infections in allogeneic stem cell transplant recipients: P525. L Wang, J Allen, C Diong, YT Goh, S Gopalakrishnan, FLWI Lim, A Ho, W Hwang,Bone Marrow Transplantation 51
  • Re-Engraftment of Prior Cord Blood Graft in a Patient with Relapsed/Refractory Acute My-eloid Leukaemia following Haploidentical Transplantation F Lim, S Bari, WYK Hwang. Int J Stem Cell Res Transplant 3 (6), 125-128
  • Evaluation of Revised Vaccination Guideline for Hematopoietic Cell Transplant Patients in Singapore General Hospital. YJ Lim, HY Ng, MF Chong, YLC Lim, YC Linn, Y Loh, YT Goh,, …, FWI Lim. Biology of Blood and Marrow Transplantation 20 (2), S292-S293
  • Evaluation of Human Polyomavirus (BKV)–Specific T Cell Immune Reconstitution in Allogeneic Haematopoietic Stem Cell Transplant Recipients. FLWI Lim, AL Teo, YSM Loh, WYK Hwang, YT Goh, KL Ling, YC Linn. Blood, The Journal of the American Society of Hematology 118 (21), 3223-3223
  • Defibrotide therapy in transplant-associated thrombotic microangiopathy is associated with improved overall survival compared to therapeutic plasma exchange: P955. F Lim, H Ng, W Hwang, Y Linn, Y Goh, C Diong, Y Lee… - Bone Marrow Transplantation, 2011
  • Hepatic iron concentration, fibrosis and response to venesection associated with the A77D and V162del “loss of function” mutations in ferroportin disease. FL Lim, JS Dooley, AW Roques, L Grellier. 2008. Blood Cell, Molecules.
  • Cutaneous follicular hyperkeratotic spicules-the first clinical sign of multiple myeloma progression or relapse. LK Tay, FL Lim, HJ Ng, HY Lee. International Journal of Dermatology 2010.

Research Trials