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Clin Assoc Prof Mariko Koh Siyue

Clin Assoc Prof Mariko Koh Siyue


Senior Consultant

Singapore General Hospital

Specialty: Respiratory and Critical Care Medicine

Clinical Interest: Bronchiectasis, Cough, Asthma, Severe Asthma

Conditions Treated by this Doctor:
Asthma, Bronchiectasis, Chronic Obstructive Pulmonary Disease (COPD), Lung Cancer, Lung Infection, Severe Asthma, Severe Asthma.

Clinical Appointments

  • Director Clinical Trial Resource Centre Singapore General HospitalSingapore General Hospital
  • Senior Consultant Respiratory & Critical Care Medicine Singapore General HospitalSingapore General Hospital

Academic Appointments

  • Physician Faculty, Respiratory Medicine for Singhealth Senior Residency Program (Jan 2019- Dec 2021)
  • Clinical Associate Professor, Office of Clinical & Academic Faculty Affairs, Duke-NUS (Since April 2016)
  • Senior Clinical Lecturer, Yong –Loo-Lin School of Medicine (since 2012)


A/P Koh is a Senior Consultant in the Department of Respiratory and Critical Care Medicine, Singapore General Hospital. She is also currently the Director of Clinical Trials and Research Centre in Singapore General Hospital.

A/P Koh‘s key clinical and research interests include Difficult- to-treat Asthma, identification and treatment of phenotypes in Severe Asthma. She established the Singapore General Hospital Severe Asthma Phenotype Study (SGH-SAPS) in 2011 and has >500 severe asthma patients in the registry who are being followed longitudinally.


  • 2014 Specialist Accreditation in Internal Medicine, Singapore
  • 2004 Specialist Accreditation in Respiratory Medicine, Singapore
  • 2001 Membership of the Royal College of Physicians (MRCP), United Kingdom
  • 1997 Bachelor of Medicine, Bachelor of Surgery (MBBS), National University of Singapore

Professional Appointments and Committee Memberships

  • Jan 2018- current: Director of Clinical Trials and Research Centre, Singapore General Hospital
  • April 2016 – current: Clinical  Associate Professor, Office of Clinical & Academic Faculty Affairs, Duke-NUS Medical School
  • 2012 – current: Senior Clinical Lecturer, Yong –Loo-Lin School of Medicine
  • 2019-2020: Senior Advisor, Singapore National Asthma Program-2
  • 2019 to current – Co-chair, ACE Asthma Clinical Practice Expert Group.
  • 2021-2023- Committee Member, Singapore National Asthma Programme- 3 
  • 2018- current: Chairman, Clinical Trials and Research Centre Advisory Committee, SGH
  • 2018- current: Member, SGH Research Executive Committee
  • 2020- current: Editorial Board: Annals Academy of Medicine, Singapore


  • Health Manpower Development Plan (Singhealth) for 12 months fellowship in Asthma and Asthma Epidemiology at Royal Melbourne Hospital, Australia. Singapore 2006
  • Singapore General Hospital Long Service Award 2008.
  • Singapore Health Quality Service Award (Silver Award) 2010
  • Service with a Heart Award  2011
  • Singapore Health Quality Service Award 2014 - Superstar (Clinician)
  • Outstanding Faculty Award. Residency in Singhealth Excels ( RiSE)  2013/2014
  • Outstanding Faculty Award. Residency in Singhealth Excels ( RiSE) 2014/2015
  • Outstanding Faculty Award. Residency in Singhealth Excels ( RiSE) 2015/2016
  • Fukuchi Award from Asian Pacific Society of Respirology for article -  Is bronchial thermoplasty cost-effective as treatment for problematic asthma patients? Singapore's perspective on a global model .Asian Pacific Society of Respirology. Fukuchi Award. Asian Pacific Society of Respirology 2018
  • SingHealth Doctors and Dentists Long Service Award ( 20 years). 2018.
  • Residency in SingHealth Excels (RiSE) Awards 2019. Faculty appreciation award.2019
  • SGH Learning Fiesta 2019 Inspiring Mentor Award 2019
  • 2019 MOH Healthcare Research Scholarship ( Master of Clinical Investigation)  2019 - 2021

Research Interests

  • Severe Asthma, Asthma, Bronchiectasis, Health Services Research


  1. Koh MS, Goh KYC, Tung MYY, Chan C.  Is Decompressive Craniectomy For Acute Cerebral Infarction Of Any Benefit? Surg Neurol 2000; 53:225-30. ( JIF 1.67)
  2. Koh MS, Saunil K, Howe HS. Late Onset Systemic Lupus Erythematosus (SLE) With Elevated CA 125 and Gastrointestinal Ischaemia. Int Med J.  2002 March; 32(3): 117-8. ( JIF 1.7)
  3. Koh MS, Goh KYC, Chen C, Howe HS. Cerebral Infarct Mimicking Glioma in Sjogren’s syndrome: Case Report. Hong Kong Med J 2002; 8: 292-4.
  4. Koh MS, AAL Hsu, P Eng.  Negative pressure pulmonary oedema in the medical intensive care unit.  Intensive Care Med 2003; 29(9):1601-4. ( JIF 5.54)
  5. Wang S, Htoo A, Loh A, Koh MS, Tan KL, Tan PH. A 41-year-old Chinese man with bilateral lung infiltrates. Singapore General Hospital Proceedings 2003; 12(2):93-102.
  6. Koh MS, Leng PH, Eng P, Hwang J.  An unusual cause of pulmonary haemorrhage in a patient with rheumatoid arthritis.  Ann Acad Med Singapore 2004;33(3):365-7 ( JIF 1.22)
  7. Ong MEH, Chan YH, Kee TYS, Chew HC, Koh MS.  Spontaneous pneumothorax outcome study (SPOT 1): a 2-year review. Eur J Emerg Med 2004; 11(2):89-94. ( JIF 1.50)
  8. Devanand A, Koh MS, Ong TH, Low SY, Phua GC, Tan KL, Eng P, Samuel M. Simple aspiration vs chest tube drainage in the management of primary spontaneous pneumothorax: A systematic review. Respir Med 2004; 98(7):579-90  ( JIF 2.92)
  9. Koh MS, Hsu AAL, Thirugnanam A. Novel management of a large chronic bronchocutaneous fistula after lobectomy. Interactive Cardiovascular and Thoracic Surgery 2005;4: 248-9 ( JIF 1.11)
  10. Koh MS, Tan BH, Kurup A, Hsu AAL, Eng P. Cavitating cryptococcal pneumonia in the immunocompetent host. Ann Acad Med Singapore 2005;34: 394-6 ( JIF 1.22)
  11. Joosten SA, Koh MS, Bu XN, Smallwood D, Irving LB. The effects of oxygen therapy in patients presenting to an emergency department with exacerbation of chronic obstructive pulmonary disease. Med J Aust 2007; 186: 235-8 ( JIF 3.79)
  12. Koh MS, Irving LB. Natural history of asthma from childhood to adulthood.  Int J Clin Pract 2007; Aug 61(8):1371-4  ( JIF 2.54)
  13. Koh MS, Irving LB. Evidence-based pharmacologic treatment for mild asthma. Int J Clin Pract 2007; Aug 61(8):1375-9   ( JIF 2.54)
  14. Chuah KL, Lim KH, Koh MS, Tan HW, Yap WM. Diagnosis of adenoid cystic carcinoma of the lung by bronchial brushing: a case report. Acta Cytol 2007;51: 563-566. ( JIF 1.56)
  15. Koh MS, Tee A, Lasserson TJ, Irving LB. Inhaled corticosteroids compared to placebo prevention of exercise induced bronchoconstriction. Cochrane Database Syst Rev 2007, Issue 3. Art No.:CD002739. DOI: 10.1002/14651858. CD002739.pub3.  ( JIF 5.94)
  16. Tee AKH, Koh MS, Gibson PG, Lasserson TJ, Wilson AJ, Irving LB. Long-acting beta2-agonists versus theophylline for maintenance treatment of asthma. Cochrane Database Syst Rev 2007, Issue 3. Art. No.:CD001281. DOI:10.1002/14651858.CD001281.pub2. ( JIF 5.94)
  17. Koh MS, Tee A, Wong P, Antippa A, Irving LB. Advances in lung cancer diagnosis and staging: Endobronchial ultrasound. Intern Med J 2008; 38(2):85-9 ( IF 1.70)
  18. Ji R, Koh MS, Irving LB.  Cutaneous sarcoidosis. Ann Acad Med Singapore 2007;36 (12): 1044-5. ( JIF 1.22)
  19. Koh MS, Irving LB. Should asthmatics be enlisted? Guest editorial. Mil Med Feb 2008; 173(2) ii-iv. ( JIF 0.77)
  20. Anantham D, Koh MS, Ernst A. Endobronchial Ultrasound. Respiratory Medicine. 2009. Respir Med. 2009 Oct;103(10):1406-14. (JIF 2.92)
  21. Phua GC , Rhee KJ , Koh M , Loo CM , Lee P. A strategy to improve the yield of transbronchial needle aspiration. Surg Endosc. 2010 Feb 21.  (JIF 3.31)
  22. Anantham D, Koh MS. Endobronchial Ultrasound guided Transbronchial Needle Aspiration (EBUS-TBNA) in the diagnosis and staging of lung cancer. Zhongguo Fei Ai Za Zhi. 2010 May;13(5):418-23.
  23. Ang SY, Tan RWY, Koh MS, Lim JFY. Economic Analysis of Endobronchial Ultrasound (EBUS) as a Tool in the Diagnosis and Staging of Lung Cancer in Singapore.  Int J Technol Assess Health Care. 2010 Apr;26(2):170-4. ( JIF 1.56)
  24. Ho KK, Ong MEH, Koh MS, Wong E, Sultana P , Raghuram J .Outpatient Management of Primary Spontaneous Pneumothorax: Is Mini Chest Tube Superior To Needle Aspiration? Am J Emerg Med. 2010 Aug 16. ( JIF 1.15)
  25. Chew HC, Chan YM, Issam AJ, Koh MS.  A Patient with Hearing Loss, Mediastinal Lymphadenopathy and Cavitatory Pulmonary Nodules. CHEST 2010; 138 :1500-1504 ( JIF 7.13)
  26. Anantham D,  Phua GC, Low SY, Koh MS. Role of Endobronchial Ultrasound in the Diagnosis of Bronchogenic Cysts. Diagnostic and Therapeutic Endoscopy; Volume 2011 (2011), Article ID 468237. 
  27. Yii AC, Koh MS. A review of psychological dysfunction in asthma: affective, behavioral and cognitive factors. J Asthma. 2013 Nov;50(9):915-21. (JIF 1.83)
  28. Low SY, MS Koh, Ong TH, Phua GC, Anantham D. Use of EBUS-TBNA in the diagnosis of granulomatous mediastinal lymphadenopathy.  Ann Acad Med Singapore 2014 April;43(4):250-4. ( JIF 1.22)
  29. Tan GL, Takano A, Cheah FK, Quek R, Koh MS. 58-year-old woman with dry cough, pulmonary nodules and rapidly progressive course of disease.   Ann Acad Med Singapore 2014 Jan;43(1):59-61. ( JIF 1.22)
  30. Koh MS, Phua GC, Ong TH, Anantham D.  Feasibility of Endobronchial Ultrasound in mechanically ventilated patients. Ann Acad Med Singapore 2014 April;43(4): 238-40. ( JIF 1.22)
  31. J Toh, Shanker P, Poopalingam R, Koh MS.   Can Bariatric Surgery Be Performed Safely In Patients With Severe Treatment-Resistant Asthma? Obesity Surgery. 2013 Nov 23. ( JIF 3.74)
  32. Lim SF, Win Wah, Pasupathi Y, Yap S, Koh MS, Tan KL , Jwee CC, Ong ME. Frequent attenders to the   Emergency Department: Patients who present with repeated asthma exacerbations.  Am J Emerg Med 2014.  Aug;32(8):895-9. ( JIF 1.15)
  33. Yii AC,  Tan GL, Tan KL, Lapperre TS, Koh MS. Fixed airways obstruction among patients with severe asthma – findings from the Singapore General Hospital -Severe Asthma Phenotype Study (SGH-SAPS). BMC Pulm Med. 2014 Dec 3;14(1):191. ( IF 2.5)
  34. Han A , Tan AH, Koh MS. Utility of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) in diagnosis of mediastinal lymphadenopathy in patients with Human Immunodeficiency Virus (HIV) infection: A case series.  BioMed Res Int  2015:257932 ( JIF 2.7)
  35. Chan AKW, Devanand A, Low SY, Koh MS . Radial Probe Endobronchial Ultrasound for the Diagnosis of Peripheral Lung lesions in a high Tuberculosis setting.  BMC Pulm Med. 2015 Aug 19;15:90.  (JIF 2.5)
  36. Tay CK, Koh MS, Takano A, Aubry MC, Sukov WR, Folpe AL. Primary Angiomatoid Fibrous Histiocytoma of the Lung with Mediastinal Lymph Node Metastasis. Hum Pathol. 2016 Aug 17. pii: S0046-8177(16)30176-9. ( IF 2.79)
  37. Yii CA, Koh MS,  Lapperre TS, Tan GL,  Chotirmall SH. The emergence of Aspergillus species in chronic respiratory disease. Front Biosci (Schol Ed). 2017. Jan 1;9:127-138. ( IF 3.52)
  38. Ho YS, Yip LY, Basri N, Chong VS, Teo CC, Tan E, Lim KL, Tan GS, Yang X, Yeo SY, Koh MS, Devanand A, Takano A, Tan EH, Tan DS, Lim TK. Lipidomic Profiling of  Lung Pleural Effusion Identifies Unique Metabotype for EGFR Mutants in Non-Small  Cell Lung Cancer. Sci Rep. 2016 Oct 14;6:35110. doi: 10.1038/srep35110. ( IF 5.82)
  39. Nguyen HV,  Bose S ,  Mital S, Yii AC,  Ang SY,  Lam SW, Devanand A,  Finkelstein E,  Koh MS. Is bronchial thermoplasty cost-effective as treatment for problematic asthma patients? Singapore’s perspective on a global model.  Respirology 2017.  Aug;22(6):1102-1109. doi: 10.1111/resp.13027 ( IF 3.078)
  40. Tan JH, Chew WM, Lapperre TS, Tan GL, Loo CM, Koh MS. Role of bronchoprovocation tests in identifying exercise-induced bronchoconstriction in a non-athletic population: a pilot study. Journal of Thoracic Disease 2017. Mar;9(3):537-542. doi: 10.21037/jtd.2017.02.70. ( IF 1.649)
  41. Yii AC ,Tan JH,  Lapperre TS, Chan AKW, Low SY , Ong TH, Tan KL , Koh MS. Long-term future risk of severe exacerbations: Distinct 5-year trajectories of problematic asthma. 2017 Sep;72(9):1398-1405. doi: 10.1111/all.13159 ( IF 6.335) 
  42. TY Poh,ǂ, MM Aogáinǂ, AKW Chan, AC Yii, VFL Yong, P Y Tiew, MS Koh, SH Chotirmall, Understanding COPD-overlap syndromes. Expert Review of Respiratory Medicine. 2017 Apr;11(4):285-298. doi: 10.1080/17476348.2017.1305895 ( IF 2.176)
  43. Goh KJ, Yii AC, Lapperre TS, Chan AK, Chew FT, Chotirmall SH, Koh MS. Sensitization to Aspergillus is associated with frequent exacerbations in severe asthma . Journal of Asthma and Allergy 2017. Apr 21;10:131-140. doi: 10.2147/JAA.S130459 ( IF 3.31)
  44. MS Koh, AC Yii , Ong YY. Asthma in Singapore: past, present and future. Editorial. Annals Acad Singapore. 2017 Mar;46(3):81-83 ( IF : 1.41)
  45. Chotirmall SH, Koh MS. Letter from Singapore. Respirology. 2017 Nov 2. doi: 10.1111/resp.13210   ( IF 3.078)
  46. Liew ZH, G Kalyanasundaram, Ong TH, Loo CM, Koh MS .Cardiopulmonary Exercise Testing for Evaluating Patients with Unexplained Exertional Dyspnoea: Potential Role in Risk Stratification?. Annals Acad Singapore ( accepted 2017 )( IF : 1.41)
  47. Tay CK, Chee MYM, Takano A,  Lim WT, Koh MS. Primary pulmonary lymphoepithelioma-like carcinoma in Singapore. Annals of Thoracic Medicine 2018.  January 4, 2018, IP: .( IF 1.529)
  48. The-Thien Tran, C Vidaillac, VY Lee, R Chandrasekaran, AY LIM, TB Low, G L Tan, J Abisheganaden, MS Koh, J Teo, K Hadinoto, SH Chotirmall. Inhalable Ciprofloxacin-Nanoplex (CIP-Np) Combined with Mannitol as a Novel Bronchiectasis Therapeutic. Int J Pharm. 2018 Jun 7;547(1-2):368-376. doi: 10.1016/j.ijpharm.2018.06.017 ( JIF 3.649)
  49. Sarah A Hiles, Erin S Harvey, Vanessa M McDonald, Matthew Peters, Philip Bardin, Paul N Reynolds, John W Upham, Melissa Baraket, Zaheerodin Bhikoo, Jeffrey Bowden, Ben Brockway, Li Ping Chung, Belinda Cochrane, Gloria Foxley, Jeffrey Garrett, Mark Hew, Lata Jayaram, Christine Jenkins, Constance Katelaris, Gregory Katsoulotos, Mariko S Koh, Vicky Kritikos, Marina Lambert, David Langton, Alexis Lara Rivero, Guy B Marks, Peter G Middleton, Aldoph Nanguzgambo, Naghmeh Radhakrishna, Helen Reddel, Janet Rimmer, Anne Marie Southcott, Michael Sutherland, Francis Thien, Peter AB Wark, Ian A Yang, Elaine Yap, Peter G Gibson.  Working while unwell: Workplace impairment in people with severe asthma . Clin Exp Allergy. 2018 Apr 20. doi:10.1111/cea.13153. [Epub ahead of print] PubMed PMID: 29676834. ( JIF 5.264 )
  50. Anthony CA Yii, Tunn-Ren Tay, Xuening Choo, Mariko S Koh, Augustine KH Tee, De-Yun Wang. Precision medicine in united airways disease: a “treatable traits” approach  . Allergy. 2018 Jun 5. doi:10.1111/all.13496. [Epub ahead of print] Review. PubMed PMID: 29869791 ( JIF . 6.335)
  51. Micheál Mac Aogáin, Ravishankar Chandrasekaran, Albert Lim Yick Hou, Low Teck Boon, Gan Liang Tan, Tidi Hassan, Ong Thun How, Amanda Hui Qi Ng, Denis Bertrand, Jayce Yu Koh, Sze Lei Pang, Zi Yang Lee, Xiao Wei Gwee, Christopher Martinus, Yang Yie Sio, Sri Anusha Matta, Fook Tim Chew, Holly R. Keir, John E. Connolly, John Arputhan Abisheganaden, Mariko Siyue Koh, Niranjan Nagarajan, James D. Chalmers and Sanjay H. Chotirmall. Immunological corollary of the pulmonary mycobiome in bronchiectasis: The CAMEB study. Eur Respir J. 2018 Jul 27;52(1). pii: 1800766. doi: 10.1183/13993003.00766-2018.  ( JIF 10.569)
  52. Andy JW Wong, JJ Chan, Mariko S Koh, Sherman WQ Lian, Marcus EH Ong. Compliance with Asthma Guidelines and Association with Outcomes in the Emergency Department of a Tertiary Care Teaching Hospital. Journal of Acute Medicine 2018 ( accepted 2018) ( JIF 0.37)
  53. Alvin Shao Qiang Ong , Aik Hau Tan , Devanand Anantham , Kiran Sharma , Shera Tan , Therese Sophie Lapperre , Kah Yee Tham , Rehena Sultana , Mariko Siyue Koh . Impact of simulation training on performance and outcomes of endobronchial ultrasound-guided transbronchial needle aspiration performed by trainees in a tertiary academic hospital. Journal of Thoracic Disease 2018 Sep;10(9):5621-5635. doi: 10.21037/jtd.2018.08.76 (JIF 2.365)
  54. Ken Goh, Mariko S Koh, Melvin Tay CK. The Aftermath of Relieving an Upper Airway Obstruction.  A Case of Post-obstructive Pulmonary Edema." .  Am J Respir Crit Care Med 2018 Jul 24. Doi:10.1164/rccm.201712-24481M . PMID:30040910. ( JIF 15.239)
  55. Vanessa M McDonald; Sarah A Hiles; Krystelle Godbout; Erin S Harvey; Guy B Marks; Mark Hew; Matthew Peters; Philip Bardin; Paul N Reynolds; John W Upham; Melissa Baraket; Zaheerodin Bhikoo; Jeffrey Bowden; Ben Brockway; Li Ping Chung; Belinda Cochrane; Gloria Foxley; Jeffrey Garrett; Lata Jayaram; Christine Jenkins; Constance Katelaris; Gregory Katsoulotos; Mariko S Koh; Vicky Kritikos; Marina Lambert; David Langton; Alexis Lara Rivero; Peter G Middleton; Aldoph Nanguzgambo,  Naghmeh Radhakrishna; Helen Reddel; Janet Rimmer; Anne Marie Southcott; Michael Sutherland; Francis Thien; Peter AB Wark; Ian A Yang; Elaine Yap; Peter G Gibson. Treatable traits can be identified in a severe asthma registry and predict future exacerbations. Respirology 2018 Sep 19. doi: 10.1111/resp.13389. ( JIF 3.257)
  56. Ken Junyang Goh, Angela Takano, Mariko Siyue Koh, Pei Yee Tiew, Choon Seng Chong, Chee Kiang Tay. A 53-year old man presenting with diplopia and cavitary lung nodules. Chest 2018. ( JIF 7.132)
  57. Micheál Mac Aogáin, Pei Yee Tiew, Albert Yick Hou Lim, Teck Boon Low, Gan Liang Tan, Tidi Hassan, Thun How Ong, Sze Lei Pang, Zi Yang Lee, Xiao Wei Gwee, Christopher Martinus, Yang Yie Sio, Sri Anusha Matta, Ong Tan Ching,  Tiong Yuen Seng, Wong Kang Ning, Sriram Narayanan, Veonice Bijin Au, Damien Marlier, Holly R. Keir, Augustine Tee, John Arputhan Abisheganaden, Mariko Siyue Koh, De Yun Wang, John E. Connolly, Fook Tim Chew, James D. Chalmers and Sanjay H. Chotirmall. Distinct 'immuno-allertypes' of disease and high frequencies of sensitisation in non-cystic fibrosis bronchiectasis . American Journal of Respiratory and Critical Care Medicine (AJRCCM) 2018. 2018 Sep 28. doi: 10.1164/rccm.201807-1355OC. ( JIF 15.239)
  58. Chai Hui Zhong, Koh Mariko Siyue. Zero Tolerance towards Asthma Deaths in Singapore: Role of the Family Doctor. The Singapore Family Physician. Vol 44(4) July- Sept 2018, page 10-13. Update in Asthma management. 
  59. Chew Si Yuan, Koh Mariko Siyue, Loo Chian Min, Julian Thumboo, Sumitra Shantakumar, David Bruce Matchar. Making clinical practice guidelines pragmatic: how Big Data and Real World Evidence can close the gap.  Ann Acad Med Singapore 2018 Dec;47(12):523-527
  60. Yii, Anthony; Tay, Tunn Ren; Puah, Ser Hon; Lim, Hui Fang; Li, Andrew; Lau, Priscilla; Tan, Raeann; Neo, Lay Ping; Chung, Kian Fan; Koh, Mariko.. Blood eosinophil count correlates with severity of respiratory failure in life-threatening asthma and predicts risk of subsequent exacerbations . Clinical and Experimental Allergy 2019. Doi: 10.1111/cea.13465 ( JIF 4.741)
  61. Tunn Ren Tay, Xue Ning Choo, Anthony Yii, Kian Fan Chung, Yiong Huak Chan, Hang Siang Wong, Adrian Chan, Augustine Tee, Mariko S Koh.. Asthma Phenotypes in a Multi-Ethnic Asian Cohort. Respiratory Medicine 157 (2019) 42–48. ( JIF: 3.237)
  62. International Severe Asthma Registry: Mission Statement. The ISAR Study Group. G. Walter Canonica , Marianna Alacqua ,  Alan Altraja , Vibeke Backer ,  Elisabeth Bel , Leif Bjermer, Unnur S. Bjornsdottir, Arnaud Bourdin , G. Brusselle , George C. Christoff , Borja G. Cosio , Richard W. Costello , J. Mark FitzGerald , Peter G. Gibson  Liam G. Heaney , Enrico Heffler , Mark Hew , Takashi Iwanaga , Rupert C. Jones , Mariko S. Koh , Chin Kook Rhee , Sverre Lehmann , Lauri A. Lehtimäki , Dora Ludviksdottir , Anke-Hilse Maitland-van der Zee , Andrew N. Menzies-Gow ,  Nikolaos G. Papadopoulos, Vicente Plaza , Luis Perez de Llano , Matthew Peters , Celeste M. Porsbjerg , Mohsen Sadatsafavi , You Sook Cho , Yuji Tohda , Trung N. Tran  ,  Eileen Wang , James Zangrilli ,  Lakmini Bulathsinhala , Victoria A. Carter , Isha Chaudhry , Neva Eleangovan , Naeimeh Hosseini , Thao L. Le , Ruth B. Murray , Chris A. Price , David B. Price . CHEST 2020 Apr;157(4):805-814.  ( JIF 7.132) 
  63. Tiew, Pei Yee; Ko, Fanny; Narayana, Jayanth Kumar ; Poh, Mau-Ern; Xu, Huiying; Neo, Han Yee; Loh, Li-Cher; Ong, Choo-Khoo; Mac Aogáin, Micheál ; Tan, Jessica; Kamaruddin, Nabilah Husna ; Sim, Gerald Jiong Hui ; Lapperre, Therese; Koh, Mariko; Hui, David; Abisheganaden, John; Tee, Augustine; Tsaneva-Atanasova, Krasimira; Chotirmall, Sanjay .“High risk’ clinical and inflammatory clusters in COPD of Chinese descent..  Chest. 2020 Feb 22. pii: S0012-3692(20)30326-3. doi: 10.1016/j.chest.2020.01.043 ( JIF: 7.132)
  64. Poh, Tuang Yeow; Tiew, Pei Yee; Lim, Albert Yick Hou ; Thng, Kai Xian ; Ali, Nur A'tikah Binte Mohamed ; Narayana, Jayanth Kumar ; Mac Aogáin, Micheál ; Tien, Zhijun; Chew, Wui Mei ; Chan, Adrian; Keir, Holly; Dicker, Alison; Hassan, Tidi; Xu, Huiying; Tee, Augustine; Ong, Thun; Koh, Mariko; Abisheganaden, John; Chalmers, James; Chotirmall, Sanjay. Increased chitotriosidase is associated with Aspergillus and frequent exacerbations in South-East Asians with bronchiectasis.. CHEST 2020 Chest. 2020 Mar 14. pii: S0012-3692(20)30446-3. doi: 10.1016/j.chest.2020.02.048.[Epub ahead of print]  ( JIF 7.132).
  65. Pei Yee Tiew, Fanny Wai San Ko, Sze Lei Pang, Sri Anusha Matta, Yang Yie Sio, Mau Ern Poh, Kenny J. X. Lau, Micheál Mac Aogáin, Tavleen Kaur Jaggi, Fransiskus Xaverius Ivan, Akira Uchida, Nicolas E. Gaultier, Daniela I. Drautz-Moses, Huiying Xu, Mariko Siyue Koh, David Shu Cheong Hui, Augustine Tee, John Arputhan Abisheganaden, Stephan C. Schuster, Fook Tim Chew and Sanjay H. Chotirmall. Environmental fungal sensitization associated with poorer clinical outcomes in COPD . European Respiratory Journal 2020. Aug 27;56(2):2000418
  66. Mac Aogáin M, Lau KJX, Cai Z, Narayana JK, Purbojati RW, Drautz-Moses DI, Gaultier NE, Jaggi TK, Tiew PY, Ong TH, Koh MS, Hou ALY, Abisheganaden JA, Tsaneva-Atanasova K, Schuster SC, Chotirmall SH .Metagenomics Reveals a Core Macrolide Resistome Related to Microbiota in Chronic Respiratory Disease.. Am J Respir Crit Care Med. 2020 Aug 1; 202 ( 3):433-447
  67. Chan SL, Ho AF, Ding H, Liu N, Earnest A, Koh MS, Chuah JS, Lau ZY, Tan KB, Zheng H, Morgan GG, Ong ME. Impact of Air Pollution and Trans-Boundary Haze on Nation-Wide Emergency Department Visits and Hospital Admissions in Singapore.   Ann Acad Med Singapore. 2020 Feb;49(2):78-87.
  68. International Severe Asthma Registry (ISAR): protocol for a global registry. Severe asthma registries: a global comparison. ISAR Study Group: Marianna Alacqua , Alan Altraja , Vibeke Backer , Elisabeth Bel , Leif Bjermer , Unnur S. Bjornsdottir ,  Arnaud Bourdin , Guy G. Brusselle , Roland Buhl , John Busby , G. Walter Canonica ,  George C. Christoff , Borja G. Cosio, Richard W. Costello , J. Mark FitzGerald , Peter G. Gibson , Liam G. Heaney , Enrico Heffler , Mark Hew , Takashi Iwanaga , David Jackson , Richard Martin , Rupert C. Jones ,  Mariko S. Koh , Chin Kook Rhee,  Sverre Lehmann, Lauri A. Lehtimäki , Dora Ludviksdottir , Anke-Hilse Maitland-van der Zee , Andrew N. Menzies-Gow , Nikolaos G. Papadopoulos , Vicente Plaza  , Luis Perez de Llano, Matthew Peters ,  Paul Pfeffer , Celeste M. Porsbjerg , Mohsen Sadatsafavi, You Sook Cho, Camille Taille , Yuji Tohda , Trung N. Tran, Eileen Wang, Michael Wechsler,  James Zangrilli , Lakmini Bulathsinhala , Victoria A. Carter , Isha Chaudhry , Neva Eleangovan , Antony Hardjojo , Naeimeh Hosseini , Thao L. Le, Ruth B. Murray , Chris A. Price , David B. Price . BMC Medical Research Methodology 2020. Au 14;20(1):212
  69. Karina R Soenjoyo,  Nivedita Nadkarni,  Mariko Siyue Koh. Comparison of exacerbation phenotypes amongst severe asthma patients . Allergy & Asthma Proc 2020 Jul 1:41( 4): e67-e79.
  70. SY Chew, JYL Leow, AKW Chan, JJ Chan, BKK Tan, D Tan, A Butta, MS Koh  .Addressing the gaps in asthma care in the Emergency Department of a Tertiary General Hospital with the A-CARE (Asthma-COPD Afterhours Respiratory Nurse at Emergency) Quality Improvement Project..BMJ Open Qual 2020 Jun;9(2):e000894
  71. Nan Liu, Marcel Lucas Chee, Chenglin Niu, Pin Pin Pek, Fahad Javaid Siddiqui,John Pastor Ansah, David Bruce Matchar, Sean Shao Wei Lam2, Hairil Rizal Abdullah, Angelique Chan, Rahul Malhotra, Nicholas Graves, Mariko Siyue Koh, Sungwon Yoon, Andrew Fu Wah Ho, Daniel Shu Wei Ting, Jenny Guek Hong Low, Marcus Eng Hock Ong .Coronavirus Disease 2019 (COVID-19): An Evidence Map of Medical Literature.. BMC Medical Research Methodology 2020 Jul 2:20(1):177
  72. Adriel Shao En Ong; Adrian Kwok Wai Chan, Rehena Sultana; Mariko Siyue Koh. Impact of Psychological Impairment on Quality of Life and Work Impairment in Severe Asthma .   J Asthma 2020 Aug 24:1-10. Doi:10.1080/02770903.2020.1808989
  73. Kheng Yong Ong,  Tze Lee Tan , Adrian Chan , Karen Li Leng Tan, Mariko Siyue Koh .Managing asthma in the COVID-19 Pandemic and Current Recommendations from GINA, NICE, BTS and National Asthma Council Australia: A Narrative Review. J Asthma 2020 Aug 11:1-8. Doi:10/1080/02770903.2020.1804578
  74. Raja Dhar, Mary Ip, Tarang Kulkarni, Sang-Heon Kim , Diahn-Warng Perng, Xin Yao, Takashi Iwanaga, Mariko Siyue Koh .Asthma Management in Asia Pacific: An Expert Review .. Respirology 2020 Dec; 25( 12) :1235-1242. .
  75. Pei Yee Tiew, Alison J. Dicker, Holly R Keir, Mau Ern Poh, Sze Lei Pang , Micheál Mac Aogáin, Branden Chua Qi Yu, Jiunn Liang Tan, Huiying Xu, Mariko Siyue Koh, Augustine Tee, John Arputhan Abisheganaden, Fook Tim Chew, Bruce E. Miller, Ruth Tal-Singer, James D. Chalmers, Sanjay H. Chotirmall. . A high-risk airway mycobiome is associated with frequent exacerbation and mortality in COPD.   Eur J Res 2020 sep 24;2002050. Doi:10.1183/13993003.020250-2020.
  76. Assessing the cost-effectiveness of mepolizumab as add-on therapy to standard of care for severe eosinophilic asthma in Singapore.  Ling Eng Tan, Wan Hui Gloria Tan, Mohamed Ismail Abdul Aziz, Mariko Siyue Koh, Tunn Ren Tay, Fiona Pearce,  Kwong Ng. J Asthma 2020 Nov 10;1-11. Doi :10.1080/02770903.2020.1837158
  77. Tiew Pei Yee, Karen Tan LL, Mariko Siyue Koh. FDA boxed warning for Montelukast: Impact on adult severe asthmatics? Annals Acad Med Singapore. Accepted Sept 2020. 
  78. Nicole YF Sieow , Mariko S Koh. Asthma management in the time of COVID-19. The Singapore Family Physician. 2020. Vol 46( 4)  July- sept 2020.
  79. Integrative micriobiomics revelas a disrupted interactome in Bronchiectasis exacerbations. Micheál Mac Aogáin,  Jayanth Kumar Narayana,  Pei Yee Tiew, Nur A'tikah Binte Mohamed Ali, BSc1, Albert Lim Yick Hou, , Holly R. Keir, BSc4, Alison J. Dicker,  Thng Kai Xian, Akina Tsang, Teck Boon Low,  Ong Thun How,  Brian Oliver,  Giam Yan Hui,  Augustine Tee,  Mariko Siyue Koh, , John Arputhan Abisheganaden,  Krasimira Tsaneva-Atanasova,  James D. Chalmers,  and Sanjay H. Chotirmall . ( Accepted by Nature Medicine 2021)
  80. The Economic Burden of Asthma in Singapore. Eric A. Finkelstein, Eden Lau, Brett Doble, Bennett Ong, and Mariko Siyue Koh. (BMC Open Resp Res 2021)

Research Trials

Research Trials/Grants/Studies

  1. Identification of asthma phenotypes in severe asthmatics. Role: Principal investigator. 
  2. Bronchial Thermoplasty for severe asthma patients with frequent acute exacerbations. Role: Principal Investigator. Awarded Health Service Development Programme (HSDP) FY2013 by Ministry of Health, Singapore. 5-year project. Grant amount S$1,550,570.
  3. Prospective study of patients with Bronchiectasis being evaluated in an outpatient clinic. Role: Co-I. 
  4. Inflammatory, Infections And Immune Perturbation In Very Early Chronic Obstructive Pulmonary Disease (COPD). Role: C0-investigator.
  5. Clinical, microbiological and immunological phenotyping of acute exacerbations among Asian COPD patients. Role: Co- Investigator.
  6. Assessing the effect of the air microbiome in chronic respiratory disease. Role: Co-I.
  7. Improving Patient Care and Clinical Outcomes For Asthma and COPD Patients Through Data Linkages and Analytics in SingHealth. Sponsor: Role- Co-I.
  8. Airway microbiome in lung cancer cases and healthy controls in Singapore. Co –I.
  9. A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center Study to Assess the Efficacy, Safety and Tolerability, and Pharmacokinetics of INS1007 Administered Once Daily for 24 Weeks in Subjects With Non-Cystic Fibrosis Bronchiectasis - The Willow Study. PI.