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Dr Chan Kwai Peng

MBBS, Dip Bact, FAMS, FRCPA

Senior Consultant

Specialty: Pathology

Sub-specialties: Virology

Clinical Appointments

Senior Consultant Microbiology Singapore General Hospital

Profile

Dr Chan is a medical virologist at the Virology Section in the Department of Pathology. After graduating with a medical degree from the National University of Singapore, she was awarded a fellowship to further her training in Microbiology at the Victoria University of Manchester in the United Kingdom. Her professional interests include rapid and serological diagnosis of viral infections.

Education

MBBS, National University of Singapore, 1981
Dp.Bact. Victoria University of Manchester, UK, 1988
FAMS (Pathology), 2003
FRCPA, 2007

Professional Appointments and Committee Memberships

2001- Director, WHO National Poliovirus Laboratory
2001- Director, WHO National Measles Virus Laboratory
2005- Director, WHO National Influenza Centre
2005- Head, Virology Section
2005- Director, National HIV Reference Lab
2005- Director, Dept of Pathology BSL3 Lab
22-26/8/2005 WHO Temporary Consultant, National Institute of Public Health Laboratory, Cambodia
8-12/12/2008 WHO Temporary Consultant, National Measles Laboratory, National Centre for Laboratory and Epidemiology, Vientiane, Lao PDR
29/10-2/11/1994 WHO/CDC Instructor, Laboratory Diagnosis of Influenza and other Respiratory Virus Infections Workshop in Beijing, China.
6/2001-6/2004 MOH Advisory Committee on Infection Control
1/10/2001-9/2005MOH Advisory Committee on HIV testing
2002- Zoonoses Advisory Committee of Singapore Zoological Gardens
1/6/2004-31/5/2007 MOH Advisory & Scientific Committee on Hepatitis and Related Disorders
11/2005- Epidemiological News Bulletin (MOH), Scientific Advisory Committee
2007- MOH Advisory Group on Pre-pandemic Influenza Vaccines
1995 - 2003 Technical Assessor, MOH audit and accreditation of HIV testing laboratories in Singapore.
2003- Technical Assessor, Singapore Accreditation Council-SINGLAS
2002-04 President, Singapore Society of Pathology
2000- Member, Inter-ministry HFMD Task Force
2006- Member, Pathology Biosafety Committee
2006- Member, Specialist Training Committee (Pathology-Microbiology)
2007- Member, Outram Campus Disease Outbreak Taskforce

Awards

Ministry of Education Scholarship, 1974-75
Government PSC Merit Scholarship for Medicine, 1976-81
HMDP Fellowship for Diploma in Bacteriology course at the University of Manchester, UK, 1987-88.
HMDP Fellowship in Quality Control and Molecular Techniques in the Diagnosis of HIV infection at the National HIV Reference Laboratory, Melbourne, Australia, 9/1/95-31/3/95.
2003 National Day Commendation Award for Overcoming SARS

Research Interests

Publications

K P Chan, Y C Chan, S Doraisingham. A severe case of hemorrhagic fever with renal syndrome in Singapore. Southeast Asian J Trop Med Pub Hlth 1996; 27(2): 408 - 410.
P McMinn, K Lindsay, D Perera, H M Chan, K P Chan, M J Cardosa. A phylogenetic analysis of enterovirus 71 strains isolated during linked epidemics in Malaysia, Singapore and Western Australia. J Virol 2001; 75(16): 7732-8.
K P Chan, P E Rollin, T G Ksiazek, Y S Leo, K T Goh, N I Paton, E H Sng, A E Ling. A survey of Nipah virus infection among various risk groups in Singapore. Epidemiol Infect 2002; 128:93-8.
CCL Ngan, SY Se Thoe, KP Chan, JEH Sng, AE Ling. Alternative strategies for confirmation of human immunodeficiency virus infection require judicious use. J Clin Microbiol 2002; 40: 314-5.
Singh S, Chow VT, Phoon MC, Chan KP, Poh CL. Direct detection of enterovirus 71 (EV71) in clinical specimens from a hand, foot and mouth disease outbreak in Singapore by reverse transcription-PCR with universal enterovirus and EV71-specific primers. J Clin Microbiol 2002; 40(8):2823-7.
K P Chan, K T Goh, C Y Chong, E S Teo, G Lau, A E Ling. Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore. Emerg Infect Dis 2003; 9:78-85.
C C T Lim, W L Lee, Y S Leo, K E Lee, P A Tambyah, K P Chan, A E Ling, H Oh, A P Auchus, N I J Paton, F Hui. Late Clinical and magnetic resonance imaging follow up of the Nipah virus infection. J Neurol Neurosurg Psych 2003; 74(1): 131-3.
C S Lim, K P Chan, K T Goh, V T K Chow. Haemagglutinin-neuraminidase sequence and phylogenetic analyses of mumps virus isolates from a vaccinated population in Singapore. J Med Virol 2003; 70: 287-92.
M J Cardosa, D Perera, B A Brown, D Cheon, H M Chan, K P Chan, P McMinn. Molecular epidemiology of EV71 strains associated with recent outbreaks in the Asia-Pacific Region: Comparative analysis based on the VP1 and VP4 genes. Emerg Inf Dis 2003; 9: 461-8.
Y J Ruan, L W Chia, A E Ling, V B Vega, H Thoreau, S Y Se Thoe, J M Chia, P Ng, K P Chiu, L Lim, T Zhang, K P Chan, L E Oon, M L Ng, Y S Leo, L F P Ng, E C Ren, L W Stanton, P M Long, E T Liu. Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection. Lancet 2003;361:1779-85
Chong C-Y, Chan K-P, Shah VA, Ng WYM, Lau G, Teo TE-S, Lai S-H, Ling A-E. Hand, foot and mouth disease in Singapore: a comparison of fatal and non-fatal cases. Acta Paediatrica 2003; 92 (10): 1163-1169
Chong PY, Chui P, Ling AE, Franks TJ, Tai YHD, Leo YS, Kaw GJL, Wansaicheong G, Chan KP, Oon LE, Teo ES, Tan KB, Zaki s, Travis WD. Analysis of deaths during the severe acute respiratory syndrome (SARS) epidemic in Singapore: Challenges in determining a SARS diagnosis. Arch Pathol Lab Med 2004;128(Feb): 195-204.
Thuan Tong Tan, Ban Hock Tan, Asok Kurup, Lynette Lin Ean Oon, Derrick Heng, Su Yun Se Thoe, Xin Lai Bai, Kwai Peng Chan, and Ai Ee Ling. Atypical SARS and Escherichia coli Bacteremia. Emerg Infect Dis 2004; 10(Feb): 10(Feb): 349-52
Lim Poh Lian, Kurup Asok, Gopalakrishna Gowri, Chan Kwai Peng, Wong Christopher W., Ng Lee Ching, Se-Thoe Su Yun, Oon Lynette, Bai Xinlai, Stanton Lawrence W, Ruan Yijun, Miller Lance D., Vega Vinsensius B, James Lyn, Ooi Peng Lim, Kai Chew Suok, Olsen Sonja J., Ang Brenda, Leo Yee Sin. Brief Report: Laboratory-acquired severe acute respiratory syndrome. NEJM 2004; 350 (17): 1740-5.
Hoe Nam Leong, Kwai Peng Chan, Ali S. Khan, Lynette Oon, Su Yun Se-Thoe, Xin Lai Bai, Daniel Yeo, Yee Sin Leo, Brenda Ang, Thomas G. Ksiazek, Ai Ee Ling. Virus-specific RNA and antibody from convalescent-phase SARS patients discharged from hospital. Emerg Infect Dis 2004; 10 (10): 1745-50.
Kwai Peng Chan. Control of Severe Acute Respiratory Syndrome in Singapore. Environ Health Prev Med 2005; 10:255-9.
Adrian C Yeo, Kwai Peng Chan, Gamini Kumarasinghe, Hui Kim Yap. Rapid detection of codon 460 mutations in the UL97 gene of ganciclovir-resistant cytomegalovirus clinical isolates by real-time PCR using molecular beacons. Mol Cellular Probes 2005; 19: 389-93.
Hoe-Nam Leong, Kwai-Peng Chan, Lynette LE Oon, Evelyn SC Koay, Lee-Ching Ng, May-Ann Lee, Timothy Barkham, Mark IC Chen, Bee-Hoon Heng, Ai-Ee Ling, Yee-Sin Leo. Clinical and laboratory findings of SARS in Singapore. Ann Acad Med 2006; 35:332-9.
BH Tan, NL Chlebicka, JG Hong Low, TYR Chong, KP Chan, YT Goh. Use of the cytomegalovirus pp65 antigenaemia assay for preemptive therapy in allogeneic hematopoietic stem cell transplantation: a real-world review. Transplant Infect Dis 2008; 10(5):325-32
Prabakaran Mookkan; Ho Hui-Ting; Prabhu Nayana; Velumani Sumathy; Szyporta Milene; He Fang; Chan Kwai-Peng; Chen Li-Mei; Matsuoka Yumiko; Donis Ruben O; Kwang Jimmy. Development of epitope-blocking ELISA for universal detection of antibodies to human H5N1 influenza viruses. PLoS ONE 2009;4(2):e4566.