Synonym(s):
For routine Uric Acid testing: 3 mL plain blood
For patients on Rasburicase: 3 mL lithium heparin blood. To pre-chill tube, keep cold on ice and send immediately. Please alert the Clinical Biochemistry Laboratory when sending these specimens.
Enzymatic, Spectrophotometry
1 – 30 days : 59 - 271 mmol/L 31 days – 3 yrs : 65 - 330 mmol/L 4 – 9 yrs : 106 - 325 mmol/L 10 – 12 yrs : 130 - 413 mmol/L 13 – 15 yrs : 130 - 413 mmol/L 15 – 17 yrs : M 218 - 578; F 178 - 459 mmol/L ≥ 18 yrs : M 218 - 578; F 178 - 459 mmol/L
Mean = 4 hrs, Range: 3 – 5 hrs
Daily
Uric acid testing for patients on Rasburicase treatment:
Rasburicase is generally used for the treatment of hyperuricaemia in tumour lysis syndrome. It lowers plasma/serum uric acid levels by metabolising Uric Acid to Allantoin and this process continues ex-vivo post blood collection. Delayed analysis of these specimens may therefore lead to falsely low Uric Acid results, giving an incorrect impression of treatment success. In order to reduce ex-vivo degradation of Uric Acid, specimens should be taken in pre-chilled lithium heparin tubes and sent on ice immediately.
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