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HERPES SIMPLEX VIRUS (HSV) ANTIBODY

Synonym(s):

​HSV IgM, HSV IgM Ab, HSV Total Ab

Lab Section Category

Description

​Herpes Simplex IgM Antibody (anti-HSV IgM) 

Herpes Simplex Virus CF Antibody (anti-HSV total)

Indications

Specimen Required

​3 – 5 mL plain blood.

(a) To diagnose acute infection, send acute sample for herpes simplex IgM antibody and a second serum taken 14 days later for herpes simplex CF antibody on the pair.

(b) For transplant patients, to determine baseline HSV titres, send single sample for herpes simplex CF antibody.

Storage and Transport

​Refrigerate samples if delay in transporting to laboratory is anticipated. Do not freeze.

Method

​Anti-HSV IgM: Immunofluorescence assay

Anti-HSV total: Complement Fixation Test

Test Results

Primary or First Episode Genital Herpes: HSV IgM positive and ≥ 4 fold rise in total antibody titre. CF (total) Ab will be absent or low (<16) in first sample.

Reactivation: IgM usually negative. ≥ 4-fold rise in total Ab titre. CF (total) Ab titre will be present in first sample.

Previous (latent) Infection: Total Ab present in the absence of IgM Ab and symptoms.

Reference Interval / Value

Turnaround Time

​Anti-HSV IgM: Urgent cases : 3 – 4 hrs; Routine cases: <1 – 4 days

Anti-HSV total: 1 – 6 days after acute or convalescent serum is received

Day(s) Test Set up

​Anti-HSV IgM : Urgent cases : Stat; Routine cases : Tuesday and Friday Anti-HSV total : Tuesday and Thursday

Remarks

​Wherever possible, send samples for virus isolation for the diagnosis of herpes simplex virus infections.

Change History Notes

Others

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