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HEPATITIS B VIRUS SEROLOGY

Synonym(s):

​HBsAg, qHBsAg, Anti-HBc IgM, HBV Core IgM Ab, Anti-HBc Total, HBV Core Total Ab, HBV e Antibody (anti-HBe), HBV Surface Antibody (anti-HBs), Anti-HBs

Lab Section Category

Description

​Hepatitis B Surface Antigen QuaLitative (HBsAg)

Hepatitis B Surface Antigen QuaNtitative (qHBsAg)

Antibody to Surface Antigen (anti-HBs) 

IgM Antibody to Core Antigen (anti-HBc IgM)

Antibody to Core Antigen (anti-HBc total) 

Hepatitis B ‘e’ Antigen (HBeAg) 

Antibody to e Antigen (anti-HBe) 

Confirmatory Test for HBsAg

Indications

Specimen Required

​3 mL plain blood for single marker. 6 – 8 mL plain blood for panel of markers.

(a) To diagnose acute hepatitis B infection or the carrier state, send blood for HBsAg QuaLitative and anti-HBc IgM.

(b) To determine immune status following past infection or vaccination, send blood for anti-HBs.

(c) In the case of a carrier, send blood for HBeAg and anti-HBe.

(d) To monitor response to HBV therapy, send blood for HBsAg QuaNtitative.

Storage and Transport

​Refrigerate samples if delay in transporting to laboratory is anticipated. Do not freeze.

Method

​Chemiluminescent Microparticle Immunoassay (for all above)

Test Results

HBsAg​Anti-HBs​Anti-HBc
IgM
​Anti-HBc
total
​HBeAg Interpretation
 
+ or -
<10 mIU/mL+++ or -Acute Hepatitis B
 + <10 or ≥ 10
mIU/mL
 - ++ or - Hep B carrier
 - ≥ 10 mIU/mL  - + - Past Infection*
 -  ≥ 10 mIU/mL - - - Vaccination*

* An anti-HBs antibody level >10 mIU/mL is considered to be protective.

Reference Interval / Value

Turnaround Time

​HBsAg, anti-HBs or anti-HBc total : <1 – 2 days

Anti-HBc IgM, HBeAg or anti-HBe : <1 – 3 days  

Confirmatory HBsAg or HBsAg QuaNtitative : <1 – 7 days

Day(s) Test Set up

​HBsAg, anti-HBs and anti-HBc total : Monday – Saturday

Anti-HBc IgM, HBeAg and anti-HBe : Monday - Friday

Confirmatory HBsAg and qHBsAg : Wednesday (except Public Holidays)

Remarks

Change History Notes

Others

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