The Cytogenetics Laboratory offers a comprehensive array of chromosome investigations for cancers, constitutional abnormalities, and prenatal and postnatal diagnosis. Analyses are performed with the aid of dedicated computerised karyotyping workstations. All reports include a description of the cytogenetic findings in accordance to the International System for Human Cytogenetic Nomenclature, and an interpretation of the results. The Laboratory also offers a wide array of metaphase and interphase Fluorescence In Situ Hybridization (FISH) tests, including rapid aneuploidy screening, microdeletion syndromes, and a host of specific malignancy tests for gene fusion / break-apart such as BCR/ABL1, PML/RARA and MLL. The FISH section also offers HER2 gene (ERBB2) amplification detection assay on breast cancer and other FISH tests for solid tissue sarcomas. The laboratory recently introduced Chromosome Microarray Analysis (CMA) as an adjuvant test to detect gains/losses. Cost effective CLL package (karyotyping plus CMA), MM package (FISH plus CMA), and standalone CMA for MDS, AML, ALL and other haematological disorders, are able to detect chromosomal gains/losses which are submicroscopic or located outside the regions of available FISH probes.
Please refer to Tables 1 and 2 for the list of available FISH probes.
Monday – Friday: 8.00am – 5.30pm
Saturday: 8.00am – 1.00pm
Provide all necessary information on the cytogenetics request form or CPOE, including:
For FISH tests, also indicate the type of FISH DNA probes required.
1. BA- Breakapart
2. DF- Dual Fusion
Click here to view all Cancer/Cancer FISH tests
Click here to view all CMA tests
Click here to view all Postnatal tests
Click here to view all PP FISH tests
Click here to view all Prenatal tests
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