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C-KIT Mutation Analysis (Exons 13 & 17)

Synonym(s):

Description

Indications

​Screening of GIST tumor samples for mutations in the KIT gene may be helpful in the diagnosis, prognostication and management of patients with GIST. These assays detect mutations from formalin-fixed paraffin-embedded GIST samples.

Specimen Required

​Paraffin embedded tissue block sent to the Histopathology Section.

Alternatively, unstained slides can be sent to the Histopathology Section. At least 8 sections of 8 µm thickness, or 12 sections of 5 µm thickness for smaller biopsies should be sent together with one H&E slide, 4 µm thick with a coverslip as a reference slide. Tumour content must be indicated and must be at least 30%.

Storage and Transport

Method

​Polymerase Chain Reaction followed by direct Sanger sequencing (In-house test)

Test Results

​Detected, Not Detected or Inconclusive

Reference Interval / Value

Turnaround Time

​5-10 days

Day(s) Test Set up

​Variable

Remarks

Change History Notes

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