Screening of GIST tumor samples for mutations in the KIT gene may be helpful in the diagnosis, prognostication and management of patients with GIST. These assays detect mutations from formalin-fixed paraffin-embedded GIST samples.
Paraffin embedded tissue block sent to the Histopathology Section.
Alternatively, unstained slides can be sent to the Histopathology Section. At least 8 sections of 8 µm thickness, or 12 sections of 5 µm thickness for smaller biopsies should be sent together with one H&E slide, 4 µm thick with a coverslip as a reference slide. Tumour content must be indicated and must be at least 30%.
Polymerase Chain Reaction followed by direct Sanger sequencing (In-house test)
Detected, Not Detected or Inconclusive
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