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BRAF V600E MUTATION TEST

Synonym(s):

Description

Indications

​This assay detects substitution of glutamic acid for valine at amino acid 600 (p.V600E) of the BRAF gene. This is the most common BRAF mutation in metastatic colorectal carcinoma, papillary thyroid carcinoma and melanoma.

Specimen Required

​Paraffin embedded tissue block sent to the Histopathology Section.
Alternatively, unstained slides can be sent to the Histopathology Section.
Note :
- At least 8 sections of 8 mm thickness, or 12 sections of 5 mm thickness for smaller biopsies should be sent together with one H&E slide, 4 mm thick with a coverslip as a reference slide.
- Tumour content must be indicated and must be at least 30%.

Storage and Transport

Method

​In-house real-time Polymerase Chain Reaction (PCR).

Test Results

​Detected, Not Detected or Inconclusive

Reference Interval / Value

Turnaround Time

​8 days

Day(s) Test Set up

​Variable

Remarks

Change History Notes

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