This assay detects substitution of glutamic acid for valine at amino acid 600 (p.V600E) of the BRAF gene. This is the most common BRAF mutation in metastatic colorectal carcinoma, papillary thyroid carcinoma and melanoma.
Paraffin embedded tissue block sent to the Histopathology Section. Alternatively, unstained slides can be sent to the Histopathology Section. Note : - At least 8 sections of 8 mm thickness, or 12 sections of 5 mm thickness for smaller biopsies should be sent together with one H&E slide, 4 mm thick with a coverslip as a reference slide. - Tumour content must be indicated and must be at least 30%.
In-house real-time Polymerase Chain Reaction (PCR).
Detected, Not Detected or Inconclusive
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