The test is used for detection of BRAF mutations in codons 594 - 601 (c.1780-c.1803) in exon 15 of the BRAF gene from Melanoma FFPE samples. 1. As a prognostic and highly predictive factor of increased response to therapy with BRAF inhibitors. 2. Assessment of clonal identity in multifocal melanoma lesions.
Paraffin embedded tissue block sent to the Histopathology Section. Alternatively, unstained slides can be sent to the Histopathology Section. At least 8 sections of 8 micrometers thickness, or 12 sections of 5 micrometers thickness for smaller biopsies should be sent together with one H&E slide, 4 micrometers thick with a coverslip as a reference slide. Tumour content must be indicated and must be at least 30%.
Direct PCR sequencing (in-house test)
Specific mutations detected, No mutations Detected or Inconclusive
5 - 10 days
Subscribe to our mailing list to get the updates to your email inbox...