Performing Laboratory: Mayo Clinic Laboratories, Rochester
2 tubes of 3 mL EDTA blood
Draw blood from the patient in a seated position.
Collect blood directly into a chilled EDTA tube and immediately keep cold in ice.
Keep cold with ice and send immediately to the laboratory.
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Mayo Clinic Laboratories Reference Interval:
0 - 2 years: 4.6 ng/mL/hour (mean)* Range: 1.4-7.8 ng/mL/hour3 - 5 years: 2.5 ng/mL/hour (mean)* Range: 1.5-3.5 ng/mL/hour6 - 8 years: 1.4 ng/mL/hour (mean)* Range: 0.8-2.0 ng/mL/hour9 - 11 years: 1.9 ng/mL/hour (mean)* Range: 0.9-2.9 ng/mL/hour12 - 17 years: 1.8 ng/mL/hour (mean)* Range: 1.2-2.4 ng/mL/hourMean data not standardized as to time of day or diet. Infants were supine, children sitting.
*Reference: Stalker HP, Holland NH, Kotchen JM, Kotchen TA: Plasma renin activity in healthy children. J Pediatr 1976;89:256-258 Peripheral vein specimenNa-deplete, upright18 - 39 years: 10.8 ng/mL/hour (mean)2.9 - 24.0 ng/mL/hour (range)
≥ 40 years: 5.9 ng/mL/hour (mean)2.9 - 10.8 ng/mL/hour (range) Na-replete, upright18 - 39 years: 1.9 ng/mL/hour (mean)≤ 0.6 - 4.3 ng/mL/hour (range)
≥ 40 years: 1.0 ng/mL/hour (mean)≤ 0.6 - 3.0 ng/mL/hour (range)
Up to 9 working days
This test is sent out to Mayo Clinic Laboratories for testing.
Mayo Clinic Renin Activity, Plasma
The plasma renin activity cannot be interpreted if the patient is treated with spironolactone (Aldactone).
Spironolactone should be discontinued for 4 to 6 weeks before testing.