Synonym(s):
EXPANDED MM FISH PANEL, COMBINED MM FISH PANEL, CLL FISH PANEL, MDS FISH PANEL
Many cytogenetic abnormalities are subtle or are found in non-dividing cells that only interphase FISH can be used to elucidate. FISH panels offered by the laboratory include: 1. Multiple Myeloma: Expanded MM FISH panel can be used to detect multiple chromosomal aberrations found in multiple myeloma. See table 2 for probe combination. 2. Combined MM FISH Panel: Inclusive of MM Hyperdiploidy FISH Panel and Expanded MM FISH Panel. 3. B-cell Chronic Lymphocytic Leukaemia: CLL FISH panel can be used to detect multiple aberrations that are often found in clonal B-cells. 4. Myelodysplastic Syndrome: MDS FISH panel is used to detect MDS.
Bone marrow in sodium/lithium heparin. For B-cell CLL, the preferred specimen is peripheral blood.
Positive or Negative for the FISH panel. FISH findings are reported in accordance to the International System for Human Cytogenomic Nomenclature (ISCN, 2016).
3 ~ 10 days
Monday – Saturday (office hours)
The FISH panel test is charged as a separate test from any accompanying cytogenetic test. Four to nine DNA probes, excluding internal control probes, are used in each panel test.
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