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EPSTEIN-BARR VIRUS (EBV) ANTIBODY

Synonym(s):

​EBV VCA IgG, EBV VCA IgG Antibody, EBV Viral Capsid Ag IgG, EBV VCA IgM, EBV VCA IgM Antibody, EBV Viral Capsid Ag IgM, EBV Ea IgA, EBV Ea IgA Antibody, EBV Early Antigen IgA, EBV VCA IgA, EBV VCA IgA Antibody, EBV Viral Capsid Ag IgA

Lab Section Category

Description

​Epstein-Barr virus VCA IgM

Epstein-Barr virus VCA IgG

EBV EA & VCA IgA Panel

Indications

Specimen Required

​3 – 5 mL plain blood.

(a) To diagnose acute infection, send single sample for EBV VCA IgM and second serum taken 10 – 14 days later if indicated.

(b) To diagnose previous infection, send single sample for EBV VCA IgG.

(c) To screen and aid in the diagnosis of nasopharyngeal carcinoma (NPC), send blood for EBV EA & VCA IgA Panel.

Storage and Transport

​Refrigerate samples if delay in transporting to laboratory is anticipated. Do not freeze.

Method

​EBV VCA IgM & IgG: Chemiluminescent Microparticle Immunoassay

EBV EA & VCA IgA Panel: Immunofluorescence assay

Test Results

Acute infection: EBV VCA IgM positive or paired sera showing seroconversion

Previous (latent) infection: EBV VCA IgG positive
                                                                                                                     

EBV-EA IgA: Negative or Positive (Titre) 

EBV-VCA IgA: Negative or Positive (Titre) 

The assay performance was validated in our laboratory in accordance with the College of American Pathologists (CAP) guidelines.

Reference Interval / Value

Turnaround Time

​EBV VCA IgM/IgG : <1 – 4 days

EBV EA & VCA IgA Panel : <1 - 7 days

Day(s) Test Set up

​EBV VCA IgM/IgG : Tuesday and Friday

EBV EA & VCA IgA Panel : Wednesday morning

Remarks

Change History Notes

Others

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