Research

As part of the National Cancer Centre – one of the leading centres in Asia engaged in cancer care, we actively seek a global role in pursuing frontline cancer care research in a bid to advance cancer care for our patients. As such, the department is also actively engaged in a wide spectrum of clinical research ranging from clinical audits to ensure best practices to translational lab based research.   

Please refer to the links below for more information

• Please refer to this link for publications published by our team [594kb, pdf]

• For the Laboratory of Applied Human Genetics website: https://www.nccs.com.sg/research-innovation/research-labs/laboratory-of-applied-human-genetics

Clinical Trials

Other than pursuing excellence in clinical care for our patients, we also actively pursue various large-scale clinical trials aimed at optimizing treatment outcomes and pushing the boundaries of cancer care for our patients. The various ongoing trials are detailed below. 

Prophylactic HIPEC for Colorectal Cancers at High Risk of Developing Peritoneal Metastasis  (Ongoing)

This trial looks at the feasibility of performing prophylactic HIPEC for colorectal cancer patients at high-risk of developing peritoneal recurrence in our institution, and determine the morbidity associated with such a procedure. 

For more information, refer to:
https://clinicaltrials.gov/ct2/show/NCT03422432?term=Prophylactic+HIPEC+for+Colorectal+Cancers+at+High+Risk+of+Developing&rank=1

Radical Resection and HIPEC for Recurrent Retroperitoneal Sarcoma (Ongoing)

This trial hypothesizes that HIPEC when coupled with radical surgery will improve locoregional control and survival of patients with retroperitoneal sarcomatosis.

For more information, refer to:

https://clinicaltrials.gov/ct2/show/NCT03792867?term=hipec+sarcoma&rank=1

Evaluation Of MRI V CT Or PET-CT in the Detection of Peritoneal Surface Malignancies (Completed and awaiting publication)

This trial aims to evaluate the use of MRI scans and compare it to CT scans to determine if it has superior accuracy in early detection of peritoneal disease.

Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) With Oxaliplatin In Patients With Peritoneal Carcinomatosis (PIPAC)(Ongoing)

This research study serves to determine the safety profile and tolerability of PIPAC with oxaliplatin whichmay offer a novel and effective option of treatment for patients with peritoneal carcinomatosis, who, at present have limited options involving the use of systemic chemotherapy. 

For more information, refer to: https://clinicaltrials.gov/ct2/show/NCT03172416?term=pipac+oxaliplatin&rank=1

Perioperative Immunonutrition for Patients Undergoing Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (Ongoing)

This study hypothesizes that perioperative immunonutrition can reduce wound infections and length of hospital stay, and improve perioperative outcomes.

For more information, refer to:

https://clinicaltrials.gov/ct2/show/NCT03430128?cond=immunonutrition+hipec&rank=1

Prospective Quality of Life Study for Colorectal Cancer Patients with Peritoneal Carcinomatosis Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (Completed)

This research paper studies patients undergoing CRS and HIPEC and attempts to identify factors that affect quality of life.

For more information, refer to:

https://www.ncbi.nlm.nih.gov/pubmed/27016293