Orbital Research Programme

Our neuroradiologists collaborate with ophthalmologists from SNEC on various projects: 

• co-developing AI algorithms using CT features to predict optic neuropathy in thyroid eye disease 
• evaluating the clinical impact of serial orbital CT assessment in patients with bilateral corneal blindness who underwent osteo-odonto-keratoprothesis surgery 

Project ARTIOS: ARTificial Intelligence in Orbital CT

This multidisciplinary collaboration with Singapore Eye Research Institute (SERI) and National University of Singapore (NUS) School of Computing uses deep learning to predict patients with thyroid eye disease who are at risk of developing optic neuropathy- a potentially blinding condition when left untreated. 

Contact

Please contact the following for more information.

• Dr Kheok Si Wei - kheok.si.wei@singhealth.com.sg 
• Dr Lishya Liauw - lishya.liauw@singhealth.com.sg 
• Dr Melissa Lee Shuhui - melissa.lee.s.h@singhealth.com.sg 
• Dr May Lim Yi Shan - may.lim.y.s@singhealth.com.sg 
• Dr Wong Chen Pong - wong.chen.pong@singhealth.com.sg 
• Prof Chan Ling Ling – chan.ling.ling@singhealth.com.sg

Sight Restoring Osteo-Odonto-Keratoprosthesis (OOKP) Surgery 

This fourteen-year series tracked the natural history of laminar resorption quantitatively and qualitatively on serial CT after OOKP surgery, conducted survival analysis, and described how standardised CT monitoring using a three-prong approach aided clinical evaluation and management, including decision-making for prophylactic OOKP exchange. 

Contact

Please contact the following for more information.

• Dr Rebekah Lee Zhuyi - rebekah.lee.z.y@singhealth.com.sg 
• Ms Sharon Kuan Ling Shi - sharon.kuan.l.s@sgh.com.sg 
• Dr Robert Chen - robert.chen@singhealth.com.sg 
• Prof Chan Ling Ling – chan.ling.ling@singhealth.com.sg

Publications:

1. Lee ZR, Teo F, Kuan S, Edmond EC, Fook-Chong S, Chen RC, Chai J, Tay A, Tan D, Chan LL. Tooth-in-eye standardized longitudinal radiological CT monitoring: Clinical impact in a fourteen-year series. Eur J Radiol. 2025 Sep;190:112242. doi: 10.1016/j.ejrad.2025.112242. Epub 2025 Jun 16. PMID: 40554943.2.   
2. Kheok SW, Hu G, Lee MH, Wong CP, Zheng K, Htoon HM, Lei Z, Tan ASM, Chan LL, Ooi BC, Seah LL. Orbital CT deep learning models in thyroid eye disease rival medical specialists' performance in optic neuropathy prediction in a quaternary referral center and revealed impact of the bony walls. Orbit. 2025 Jul 1:1-9. doi: 10.1080/01676830.2025.2521868. Epub ahead of print. PMID: 40591440.3. 
3. A Chng CL, Zheng K, Kwee AK, Lee MH, Ting D, Wong CP, Hu G, Ooi BC, Kheok SW. Application of artificial intelligence in the assessment of thyroid eye disease (TED) - a scoping review. Front Endocrinol (Lausanne). 2023 Dec 20;14:1300196. doi: 10.3389/fendo.2023.1300196.4.  
4. Chan LL, Tan HE, Fook-Chong S, Teo TH, Lim LH, Seah LL. Graves' Ophthalmopathy: The Bony Orbit in Optic Neuropathy, Its Apical Angular Capacity and Impact on Prediction of Risk. AJNR 2009 Mar;30(3):597-602.