Guide to Actinium-225 PSMA Therapy

Actinium-225 (225Ac) PSMA therapy is an advanced targeted treatment for prostate cancer. This innovative therapy uses radioactive Actinium-225 attached to molecules that specifically seek out prostate cancer cells expressing PSMA (Prostate-Specific Membrane Antigen). This targeted approach allows for precise delivery of radiation to cancer cells whilst minimising effects on healthy tissue.

The treatment is administered through an infusion, during which our medical team will carefully monitor your vital signs. Following treatment, you may undergo Whole Body Scans to assess the distribution of the therapy.

Essential Care Guidelines

Hydration and Medication

Drink at least 1 litre of fluid daily, unless your doctor advises otherwise. Continue taking all your prescribed medications as directed.

Personal Hygiene

Maintain thorough personal hygiene with daily showers and careful handwashing after toilet visits. As the treatment is partially excreted through urine, please ensure all bodily fluids are properly cleaned from surfaces and double flush the toilet after use. Wash any soiled linen separately from family laundry.

Safety Precautions

For the first two days after treatment:

Avoid crowded public spaces
Sleep separately from adults and avoid intimacy
Maintain arm's length distance from children under 12 and pregnant women
Sit whilst urinating (including men)
Double flush toilet after use
Sleep separately from pregnant women and children under 12

Additional Precautions

Avoid impregnating your partner for six months following treatment. You may return to work when you feel well enough.

Travel Information

Over the next four weeks, you must carry your discharge note when travelling as you may trigger radiation detection devices at airports, public transportation facilities, and other security checkpoints due to low radiation levels. If you plan to travel overseas shortly after treatment, please request a travel memo from your doctor.

Medical Attention

Seek immediate medical attention if you experience:

Fever of 38°C or above
Persistent vomiting
Any prolonged symptoms that concern you

During office hours, visit the Department of Nuclear Medicine and Molecular Imaging at Block 2 Basement 1. After office hours, please go to the SGH Emergency Department.