Clinical Services | Singapore General Hospital

Division of Radiological Sciences

Nuclear Medicine and Molecular Imaging

Clinical Services

Fellowship

Research

General Nuclear Medicine Imaging

Bone scintigraphy for assessment of bone metastases and other skeletal abnormalities
Cardiac studies: Nuclear cardiology services including myocardial perfusion imaging, radionuclide gated-ventriculography, cardiac first-pass study and Tc-99m pyrophosphate imaging for cardiac amyloidosis
Neurological imaging:
- Brain perfusion imaging for cerebrovascular insufficiency and brain death
- DaTSCAN for neurodegenerative disease
- Cisternoscintigraphy for CSF leak detection
Renal studies: Complete renal diagnostics including
- MAG3 renography for evaluation of kidney function and drainage
- Captopril studies for renovascular hypertension assessment
- DMSA renal cortical imaging for scarring and pyelonephritis
- Nuclear medicine GFR (Glomerular Filtration Rate) measurement for precise kidney function assessment
Endocrine Imaging:
- Thyroid scintigraphy with correlative ultrasound for functional assessment of thyroid gland
- Parathyroid scintigraphy with ultrasound correlation for precise lesion localisation in hyperparathyroidism
Gastrointestinal studies: A wide range of diagnostic procedures including:
- Radiolabelled red blood cells scans
- Meckel's scan
- Hepatobiliary imaging
- Gastric emptying study
- Liver-spleen scan
- Peritoneal imaging
Respiratory Studies:
- Lung studies including V/Q scan for pulmonary embolism
- Quantitative lung perfusion scan for pre-surgical assessment
Other Imaging:
- I-123/I-131 MIBG imaging for neuroblastomas/neuroendocrine tumours
- Lymphoscintigraphy for lymphoedema assessment
- Sentinel node scintigraphy for breast cancers and melanoma
- Radionuclide occult lesion localisation (ROLL) for breast cancers
- Radiolabelled white blood cells scan for infection localisation

Bone Densitometry

Bone densitometry (DXA)
Densitometric vertebral fracture assessment (VFA)
DXA Body Composition Analysis (BCA) Test
Full-length Femur Imaging (FFI)

Positron Emission Tomography (PET)

PET is an advanced molecular imaging technique for oncology, cardiology, neurology and infection/inflammation. An integrated PET/CT scanner provides functional information with anatomic correlation.

PET/CT Scans Advisory

Nuclear Medicine Therapy

Radioiodine Therapy
Oral administration of I-131 for the treatment of thyrotoxicosis (e.g. Graves’ disease, toxic multinodular goitre or toxic adenoma) and differentiated thyroid carcinomas.
Radio-iodine(I-131) Treatment

Selective Internal Radiation Therapy (SIRT)
Local radiation therapy for liver tumours. The procedure is performed in close coordination with interventional radiologists by delivering radioactive Y-90 microspheres into the arteries supplying the tumours.

Peptide Receptor Radionuclide Therapy (PRRT)
Molecular targeted therapy for inoperable metastatic well- or moderately-differentiated neuroendocrine tumours. The treatment is performed with intravenous administration of radioactive somatostatin analogue (e.g. Lu-177 or Y-90-labeled radiopeptide).
Peptide Receptor Radionuclide Therapy

Lutetium-177 PSMA (LuPSMA) Radionuclide Therapy
A theranostic approach in the treatment of metastatic prostate cancer. This targeted radioligand therapy works by specifically binding to Prostate-Specific Membrane Antigen (PSMA), a protein highly expressed on the surface of prostate cancer cells.
Lutetium-177 PSMA (LuPSMA) radionuclide therapy

Radium223 Therapy
A targeted alpha-emitting radiopharmaceutical specifically approved for the treatment of patients with castration-resistant prostate cancer (CRPC) with symptomatic bone metastases and no known visceral metastases.

Radiosynovectomy
Radiosynovectomy (also known as radiation synovectomy or radiosynoviorthesis) is a minimally invasive therapeutic procedure used to treat persistent joint inflammation that has not responded adequately to conventional treatments. This therapy involves the intra-articular injection of radioactive isotopes to irradiate and ablate inflamed synovial tissue.
Radiosynovectomy

I-131 MIBG Therapy
A targeted radiation treatment that uses radioactive molecules to treat specific types of neuroendocrine tumours. This specialised treatment is particularly effective for neuroblastoma in children and phaeochromocytoma in adults.

Non-Imaging Nuclear Medicine Tests

Cr-51 EDTA renal clearance study for evaluation of glomerular filtration rate
Helicobacter pylori C-14 breath test (Urea Breath Test)
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Hormone immunoassays for assessing thyroid, fertility and metabolic functions (from our Endocrine Laboratories)

Production of Radiopharmaceuticals

Our radiochemistry laboratory synthesises a comprehensive range of radiopharmaceuticals for in-house use as well as for sale to other centres in Singapore. Our staff also manage the operations of the Positron Tracers Pte Ltd (PTPL) cyclotron facility (a GMP-certified radiochemistry facility for synthesis of FDG) which is a 3-partner joint venture company, physically located in our department.