Clin Assoc Prof Kelvin Loke Siu Hoong

​Trained in clinical nuclear medicine (diagnostic and therapeutic), I have a keen interest in nuclear medicine therapeutics, in particular, the radionuclide treatment of rare diseases like paediatric neuroblastoma and neuroendocrine tumours. Have interest in clinical research including translating nuclear medicine probes from the bench to bedside and promoting radionuclide therapies within the local population of Singapore.

Have been working with various clinicians from SGH and KKH to establish protocols for the treatment of paediatric patients with neuroblastoma using high dose I-131 metaiodobenzylguanidine.

• HMDP Clinical Fellowship 2010 to 2011 at Nuclear Medicine Division, Hospital of the University of Pennsylvania
• Completed Advanced Speciality Training in Nuclear Medicine 2009

• Adjunct Assistant Professor, Duke-NUS Medical School
• ​Chairman, Chapter of Nuclear Medicine College of Radiologists 2017-19
• Director, Functional and Molecular Imaging, RadSci ACP
• JCST exit exam committee member
• Member Residency Advisory Committee (Nuclear Medicine)
• Core Faculty, Residency Programme for Nuclear Medicine

• ​Singapore Health Quality Award 2015
• Service with a Heart 2013
• SGH Long Service Award 2012

• Radionuclide therapies

Research (Principal Investigator)

1. A phase II randomized, double-blinded, placebo-controlled trial of radium-223 dichloride versus placebo when administered to metastatic HER2 negative hormone receptor positive breast cancer with bone metastases treated with hormonal treatment background therapy.
2. A phase II randomized, double-blinded, placebo-controlled trial of radium-223 dichloride versus placebo when administered to metastatic HER2 negative hormone receptor positive breast cancer with bone metastases treated with the standard-of-care treatment exemestane and everolimus.
3. Determining the feasibility of Peptide Receptor Radionuclide Therapy by means of Gallium 68 DOTAPEPTDE PET/ CT Imaging in non-radioiodine-avid differentiated thyroid carcinoma patients.
4. “Is the partition model superior to empirical BSA method for delivery of Yttrium-90 resin microspheres in hepatocellular carcinoma?”
5. Pilot Study of Somatostatin Receptor Imaging in Nasopharyngeal Cancer.
6. 18-Fluoromethylcholine PET/CT in the pre and post treatment evaluation of prostate cancer.
7. Technetium-99m labeled Isoniazid planar whole body imaging coupled with hybrid Single Photon Emission Computed Tomography / Computed Tomography (SPECT/CT) imaging for active tuberculosis infections. Proof of clinical concept.

Publications

1. National Cancer Centre Singapore Consensus Guidelines for Hepatocellular Carcinoma
   Pierce K. H. Chow, Su Pin Choo, David C. E. Ng, Richard H. G. Lo, Michael L. C. Wang, Han Chong Toh, David W. M. Tai, Brian K. P. Goh, Jen San Wong, Kiang Hiong Tay, Anthony S. W. Goh, Sean X. Yan, Kelvin S. H. Loke, Sue Ping Thang, Apoorva Gogna, Chow Wei Too, Farah Gillian Irani, Sum Leong, Kiat Hon Lim, Choon Hua Thng. Liver Cancer 2016;5:97–106
2. Gender, Race, and Age at Diagnosis as risk factors for metastasis or recurrence among 1,657 Thyroid cancer patients treated with Radioiodine across 40 years in Singapore
   Yung Hsiang Kao, Hui Kong Gan, Sumbul Zaheer, Winnie W C Lam, Kelvin S H Loke, Wai Yin Wong, David C E Ng, Anthony S W Goh. Oncol Res Treat 2015:18;38(12):679-82
3. The role of PET/CT in the evaluation of skeletal metastases.
   Anbalagan Kannivelu, Kelvin S.H. Loke, Tian Yue Kok, Saabry Yusof Osmany, Syed Zama Ali, Lu Suat-Jin, David Chee-Eng Ng. Seminars in Musculoskeletal Radiology 04/2014; 18(2):149-65
4. Oncogenic osteomalacia presenting as a crippling illness in a young man.
   Melvin Khee-Shing Leow, Laniyati Hamijoyo, Huiling Liew, Umapathi Thirugnanam, Mathew Hern Wang Cheng, Kelvin S H Loke, Michael Song Kim Teo, Khoon Leong Chuah, Hiok Hee Chng
   The Lancet.2014; 384: 1236
5. Post-thyroidectomy neck ultrasonography in patients with thyroid cancer and a review of the literature.
   Sumbul Zaheer, Andrew Tan, Ang Ee Sin, Kelvin Loke, Kao Yung Hsiang, Anthony Goh, Wong Wai Yin. Singapore Med J Apr 2014; 55(4): 177-82
6. Dosimetric Considerations in Radioimmunotherapy and Systemic Radionuclide Therapies: A Review .
   Kelvin S. H. Loke, Ajit K. Padhy, David C. E. Ng, Anthony S.W. Goh, and Chaitanya Divgi
   World J Nucl Med. 2011 Jul-Dec; 10(2): 122–138
7. Pseudoaneurysm and coronary abscess secondary to coronary stent fracture identified with Tc-99m Hexamethylpropyleneamine Oxime (HMPAO) labelled white blood cell SPECT/CT scintigraphy.
   Kelvin S.H. Loke, H Y Loi, Anthony S.W. Goh, David C.E. Ng. Clin Nucl Med; May 2011:36(5):397-399
8. Pancreatic Metastasis Detected by F-18 FDG PET/CT in a Patient With Breast Cancer
9. Lam, Winnie Wing-Chuen; Loke, Kelvin Siu-Hoong; Loi, Hoi Yin; Padhy, Ajit Kumar
   Clin Nucl Med; June 2011;36(6):479-80.
10. Role of Tc-99m DMSA (V) scanning and serum calcitonin monitoring in the management of medullary thyroid carcinoma.
    Howe T C, Padhy A K, K Loke, Magsombol B, Goh A.
    Singapore Med J 2008; 49(1):19-22.

Book Chapters

1. Pitfalls in Musculoskeletal Radiology : Nuclear Medicine Imaging Artifacts.
   Springer 2017. 2nd Author
2. Neuroendocrine Tumors: Peptide Receptor Radionuclie Therapy of Neuroendocrine Tumors.
   Red cells 2013. 2nd Author