Clin Assoc Prof Isaac Seow-En

Dr Isaac Seow-En graduated from the National University of Singapore in 2009 and has been a Specialist Colorectal Surgeon with Singapore General Hospital Department of Colorectal Surgery and the National Cancer Centre Singapore since 2017. In 2020, he completed a year-long fellowship training in advanced minimally invasive colorectal surgery in Taiwan. He is currently a Clinical Associate Professor of Surgery at Duke-NUS Medical School, Adjunct Assistant Professor at National University of Singapore Medical School, and Adjunct Senior Lecturer at Lee Kong Chian School of Medicine. He is also a Clinical Core Faculty Member of the SingHealth General Surgery Residency Programme, and an Executive Committee Member of the Society of Colorectal Surgeons, Singapore. He is the President of the Singapore Branch of the International NOSES Alliance since 2025.

Dr Seow-En has published over 90 peer-reviewed publications and 7 book chapters, particularly in innovative surgical techniques and complex colorectal cancer treatment. He has a keen interest in laparoscopy, transanal minimally invasive surgery (TAMIS) for rectal cancer, natural orifice specimen extraction surgery (NOSE), colorectal cancer survivorship, as well as surgical education

• President, International Natural Orifice Specimen Extraction Surgery (NOSES) Alliance, Singapore Branch, 2025 - 2029
• Chairman, Organising and Scientific Committee, Singapore Society of Colorectal Surgeons Scientific Symposium, August 2025
• Course Director, Minimally Invasive Rectal Surgery Masterclass, October 2024
• Course Director, Intracorporeal Anastomosis Masterclass, August 2024
• Executive Committee Member, Society of Colorectal Surgeons (Singapore)
• Fellow, The Royal College of Surgeons (Edinburgh)
• Scientific Committee Co-Chairman, Asia-Pacific Federation of Coloproctology Congress 2023
• Organising and Scientific Chairman, Inaugural SingHealth Colorectal Congress 2022

I. Peer-Reviewed Publications

1. Seow-En I, Tan JKTT, Chow SME, Zhao Y, Tan IEH, Tan EJKW, Au MKH, Tan MWJ. Early discharge within 48 h after minimally invasive colorectal resection: a propensity score-matched evaluation of clinical outcomes, resource utilization, and patient-reported experience. Surg Endosc. 2026 Apr 15. doi: 10.1007/s00464-026-12801-w. Epub ahead of print.
2. Tan JH, Chang JHE, Seow-En I. Salvage TaTME with Turnbull-Cutait delayed coloanal anastomosis after failed watch-and-wait for rectal cancer — a video vignette. Colorectal Dis. 2026;28(6):e70504. doi: 10.1111/codi.70504.
3. Seow-En I, Chee MYM, Liu SW, Wong YWY, Ang JX. First worldwide comparison of right hemicolectomy for colon cancer using vaginal natural orifice transluminal endoscopic surgery (VNOTES) versus transvaginal natural orifice specimen extraction surgery (TVNOSE). Tech Coloproctol. 2026 Apr 18. doi: 10.1007/s10151-026-03287-8. Epub ahead of print. PMID: 42000922.
4. Liu Z, Wang Z, Yang L, Ma Z, Wang S, Zhou H, Tang L, Wei B, Yu S, Feng Q, Tang Q, Liu R, Wang F, Wang G, Zhou C, Niu W, Wei Y, Sun X, Yao H, Peng J, Ma D, Hu J, Zheng Y, Jiang B, Han F, Xiong Z, Mo X, Li T, He Q, Liu Z, Li Y, Zhang T, Kang L, Wang Z, Ding K, Zhang W, Tsarkov P, Tulina I, Artur I, Efetov S, Chen WT, Shen MY, Kayaalp C, Kim SH, Lee SH, Lee WY, Min BS, Kim S, Khan J, Seow-En I, Hung TX, Docimo L, Nishimura A, Uehara K, Saklani A, Ng SM, Meng CSW, Luo G, Parvaiz A, Mongardini FM, Dulskas A, Melani AGF, Forgione A, Naeem M, Mah JJ, Wang X. International guideline on natural orifice specimen extraction surgery (NOSES) for gastric cancer (2025 version). Clin Surg Oncol. 2026;5(1):100117.
5. Seow-En I, Chen LRH, Zhao Y, Ng YY, Tan EK. Cryotherapy reduces pain post-hemorrhoidectomy (CYPHER): a randomized, controlled, superiority trial of intra-anal ice after surgery for grade III hemorrhoids. Ann Coloproctol. 2025 Dec;41(6):537-544. doi: 10.3393/ac.2025.00549.0078. PMID: 41486911; PMCID: PMC12766388.
6. Chua WY, Yong A, Lim O, Seow-En I, Chong D, Wong E, Han S, Koo SL, Tan I, Ng KYY. The impact of socioeconomic status on overall survival in patients with colorectal cancer: a systematic review and meta-analysis. ESMO Gastrointest Oncol. 2025 Sep;10:100243. doi: 10.1016/j.esmogo.2025.100243.
7. Seow-En I, Chee MYM, Soh W. Laparoscopic 3-port total colectomy with D3 lymphadenectomy and transvaginal natural orifice specimen extraction (NOSE) for synchronous ascending and rectosigmoid colon tumours — a video vignette. Colorectal Dis. 2025 Sep;27(9):e70208. doi: 10.1111/codi.70208. PMID: 40890914.
8. Tan TJK, Ng SM, Lee TSQ, Tan EK, Seow-En I. Abdominoperineal pull-through with delayed coloanal anastomosis for pelvic anastomotic failure — a systematic review. Tech Coloproctol. 2025 Aug 18;29(1):164. doi: 10.1007/s10151-025-03206-3. PMID: 40824311; PMCID: PMC12361269.
9. Seow-En I, Khoo CY, Zhao Y, Liu SW, Yew KX, Tan IE, Ang KA, Au MKH, Tan EK. The impact of body mass index on colorectal surgery: a short-term outcome and cost analysis in an Asian cohort of 3169 patients. Colorectal Dis. 2025 Aug;27(8):e70192. doi: 10.1111/codi.70192. PMID: 40751348.
10. Sica GS, Anania G, Fiorani C, Siragusa L, Vinci D, Caricato M, Delrio P, Agrusa A, Baldazzi G, Reddavid R, Pellino G; RRoC-STAR Collaborative Group (including Seow-En I). Standardization of the surgical technique and reporting for radical right colectomy with central vascular ligation and complete mesocolic excision (RRoC-STAR): Delphi consensus. BJS Open. 2025 May 7;9(3):zraf066. doi: 10.1093/bjsopen/zraf066. PMID: 40503608; PMCID: PMC12159727.
11. Kuzu MA, Benlice C, Parvaiz A, Gorgun E, Bertelsen CA, Wexner S, Dozois EJ, Hohenberger W, Miskovic D, Sugihara K, Spinelli A, Wiggers T, Lee WY, Möslein G, Tsarkov P, Basany EE, Patron Uriburu JC, Perez RO, Lynch C, Liu Z, Hahnloser D, Nilsson PJ, Chowdri NA, Brown G, Rouanet P, Madoff RD, West NP, Sahin T, Elhan AH, Bordeianou LG; Colon Cancer Delphi Consensus Study Group. Standardizing the definition of each colon cancer segment: Delphi consensus on clinical decision-making for oncologic outcomes. Dis Colon Rectum. 2025 Jul;68(7):835-844. doi: 10.1097/DCR.0000000000003739. PMID: 40214091.
12. Seow-En I, Ng WK, Padernal Villanueva ME, Tan EJ. Colorectal natural orifice specimen extraction surgery in an Asian cohort: does obesity matter? Minerva Surg. 2025;80(4):293-299. doi: 10.23736/S2724-5691.25.10857-5.
13. Kitaguchi D, Seow-En I (co-first authors), Shen MY, Ke TW, Kim JS, Kim J, Ito M, Chen WT; Asian Colorectal Cancer Collaborative. Delayed vs immediate coloanal anastomosis after total mesorectal excision for low rectal cancer: an international multicenter retrospective cohort study. J Am Coll Surg. 2025 Sep;241(3):448-459. doi: 10.1097/XCS.0000000000001410. PMID: 40226931.
14. Chia S, Wen Seow JJ, Peres da Silva R, Suphavilai C, Shirgaonkar N, Murata-Hori M, Zhang X, Yong EY, Pan J, Thangavelu MT, Periyasamy G, Yap A, Anand P, Muliaditan D, Chan YS, Siyu W, Yong CW, Hong N, Ran G, Sim NL, Guo YA, Yi Teh AX, Wei Ling CC, Wei Tan EK, Pei Cherylin FW, Chang M, Han S, Seow-En I, Chen Hui LR, Hsia Gan AH, Yap CK, Ng HH, Skanderup AJ, Chinswangwatanakul V, Riansuwan W, Trakarnsanga A, Pithukpakorn M, Tanjak P, Chaiboonchoe A, Park D, Kim DK, Iyer NG, Tsantoulis P, Tejpar S, Kim JE, Kim TI, Sampattavanich S, Tan IB, Nagarajan N, DasGupta R. CAN-Scan: a multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer. Cell Rep Med. 2025 Apr 15;6(4):102053. doi: 10.1016/j.xcrm.2025.102053. PMID: 40187357; PMCID: PMC12047494.
15. Chee MYM, Lin W, Ong SYK, Chiang J, Thane NN, Seow-En I. Multifocal intraluminal gastric and colonic recurrence of anorectal signet-ring cell carcinoma: a case report. Arch Colorect Dis. 2025 Jan;1(1):43-46.
16. Seow-En I, Lee TSQ, Tan EK, Ang JX. Vaginal natural orifice transluminal endoscopic surgery D3 right hemicolectomy with intracorporeal anastomosis for caecal cancer — a video vignette. Colorectal Dis. 2025 Jan;27(1):e17270. doi: 10.1111/codi.17270. PMID: 39834199.
17. Chen HLR, Chong QD, Tay B, Zhou S, Wong EYT, Seow-En I, Tan KK, Wang Y, Seow A, Tan KE, Tan BHI, Tan SH. Trends in early-onset colorectal cancer in Singapore: epidemiological study of a multiethnic population. JMIR Public Health Surveill. 2025 Feb 14;11:e62835. doi: 10.2196/62835. PMID: 39725547; PMCID: PMC11888020.
18. Lim JSH, Koo SL, Tan IB, Seow-En I. Combined transanal and laparoscopic approach for full-thickness local excision of locally advanced rectal cancer following near-complete response after chemotherapy. World J Colorectal Surg. 2024;13:95-98.
19. Seow-En I, Villanueva ME, Seah AWM, Tan EJKW, Ang JX. Vaginal natural orifice transluminal endoscopic surgery (vNOTES) right hemicolectomy with intracorporeal anastomosis for cecal cancer. Tech Coloproctol. 2024 Aug 14;28(1):108. doi: 10.1007/s10151-024-02971-x. PMID: 39143393.
20. Seow-En I, Villanueva ME, Eu EW, Tan EJKW. Laparoscopic D3 right hemicolectomy with intracorporeal anastomosis. Tech Coloproctol. 2024 Aug 2;28(1):92. doi: 10.1007/s10151-024-02965-9. PMID: 39093328.
21. Seow-En I, Koh YX, Tan EK, Tan EK. Simultaneous laparoscopic colectomy and liver metastasectomy with natural orifice specimen extraction: a proof-of-concept study. Heliyon. 2024 Jun 14;10(12):e33065. doi: 10.1016/j.heliyon.2024.e33065. PMID: 39022098; PMCID: PMC11252925.
22. Ng YY, Tan KY, Yun Z, Seow-En I, Chok AY, Chuang J, Loy MS, Tan EK. Efficacy of traditional acupuncture compared to biofeedback therapy in fecal incontinence: a randomized controlled trial. Dis Colon Rectum. 2024 Oct;67(10):1313-1321. doi: 10.1097/DCR.0000000000003357. PMID: 38954475.
23. Shanmugam R, Majee P, Shi W, Ozturk MB, Vaiyapuri TS, Idzham K, Raju A, Shin SH, Fidan K, Low JL, Chua JYH, Kong YC, Qi OY, Tan E, Chok AY, Seow-En I, Wee I, Macalinao DC, Chong DQ, Chang HY, Lee F, Leow WQ, Murata-Hori M, Xiaoqian Z, Shumei C, Tan CSH, Dasgupta R, Tan IB, Tergaonkar V. Iron-(Fe3+)-dependent reactivation of telomerase drives colorectal cancers. Cancer Discov. 2024 Oct;14(10):1940-1963. doi: 10.1158/2159-8290.CD-23-1379. PMID: 38885349.
24. Seow-En I, Tan IE, Zheng V, Wu J, Zhao Y, Ang KA, Au MKH, Tan EJKW. A retrospective cohort study of intracorporeal versus extracorporeal anastomosis for right hemicolectomy with cost-effectiveness analysis. Tech Coloproctol. 2024 Jun 8;28(1):66. doi: 10.1007/s10151-024-02944-0. PMID: 38850445.
25. Chang JHE, Xu H, Zhao Y, Wee IJY, Ang JX, Tan EK, Seow-En I. Transvaginal versus transabdominal specimen extraction in minimally invasive surgery: a systematic review and meta-analysis. Langenbecks Arch Surg. 2024 Jun 3;409(1):172. doi: 10.1007/s00423-024-03361-5. PMID: 38829526; PMCID: PMC11147895.
26. Chan C, Tan YC, Lim EW, Teo JY, Lin J, Tan WJ, Tay GCA, Tan EK, Seow-En I. Evaluating the surgical trainee ergonomic experience during minimally invasive abdominal surgery (ESTEEMA study). Sci Rep. 2024 May 31;14(1):12502. doi: 10.1038/s41598-024-63516-8. PMID: 38822017; PMCID: PMC11143188.
27. Wee IJY, Seow-En I, Chok AY, Sim E, Koo CH, Lin W, Meihuan C, Tan EK. Postoperative outcomes after prehabilitation for colorectal cancer patients undergoing surgery: a systematic review and meta-analysis of randomized and nonrandomized studies. Ann Coloproctol. 2024 Jun;40(3):191-199. doi: 10.3393/ac.2022.01095.0156. PMID: 38752322.
28. Seow-En I, Villanueva ME, Tan EK. The utility of the surgical glove bag for contamination control during antiperistaltic intracorporeal anastomosis after laparoscopic D3 right hemicolectomy: a video vignette. Colorectal Dis. 2024 Apr;26(4):459-461. doi: 10.1111/codi.16997. PMID: 38649960.
29. Tan SJJ, Tan EK, Ng YYR, Sultana R, Allen JC, Seow-En I, Mathew R, Chok AY. Venous thromboembolism among Asian populations with localized colorectal cancer undergoing curative resection: is pharmacological thromboprophylaxis required? A systematic review and meta-analysis. Ann Coloproctol. 2024 Jun;40(3):200-209. doi: 10.3393/ac.2022.01046.0149. PMID: 38752323.
30. Lin W, Chok AY, Seow-En I, Tan EK. Stenting as bridge to surgery versus upfront emergency resection for non-metastatic left-sided obstructing colorectal cancer: risk of peritoneal recurrence and long-term outcomes. Surg Endosc. 2024 May;38(5):2632-2640. doi: 10.1007/s00464-024-10780-4. PMID: 38503904.
31. Koo CH, Xue B, Yik V, Seow-En I, Ong MEH, Tan EK. Using heart rate variability to develop a predictive model for post-operative cardiovascular complications following major abdominal surgery: a pilot study. World J Surg. 2024 Mar;48(3):585-597. doi: 10.1002/wjs.12077. PMID: 38501562.
32. Seow-En I, Li KK, Tan EK. Intracorporeal antimesenteric ancillary trocar: an anastomotic technique facilitating natural orifice specimen extraction in left-sided colorectal surgery. Colorectal Dis. 2024 Apr;26(4):766-771. doi: 10.1111/codi.16884. PMID: 38302860.
33. Seow-En I, Wu J, Tan IE, Zhao Y, Seah AWM, Wee IJY, Ng YYR, Tan EJKW. Transanal total mesorectal excision with delayed coloanal anastomosis (TaTME-DCAA) versus laparoscopic total mesorectal excision (LTME) and robotic total mesorectal excision (RTME) for low rectal cancer: a propensity score-matched analysis of short-term outcomes, bowel function, and cost. Surg Laparosc Endosc Percutan Tech. 2024 Feb;34(1):54-61. doi: 10.1097/SLE.0000000000001247. PMID: 37987634; PMCID: PMC10829900.
34. Seow-En I, Koh YX, Zhao Y, Ang BH, Tan IE, Chok AY, Tan EJKW, Au MKH. Predictive modeling algorithms for liver metastasis in colorectal cancer: a systematic review of the current literature. Ann Hepatobiliary Pancreat Surg. 2024 Feb;28(1):14-24. doi: 10.14701/ahbps.23-078. PMID: 38129965.
35. Ng YY, Seow-En I, Chok AY, Lee TS, Palanisamy P, Tan EK. Surgical and short-term oncological safety of total neoadjuvant therapy in high-risk locally advanced rectal cancer. ANZ J Surg. 2024 Feb;94(1-2):175-180. doi: 10.1111/ans.18739. PMID: 37849414.
36. Chee MYM, Goh CSL, Pek WS, Tan EKW, Seow-En I. Dufourmentel rhomboid flap versus the Karydakis and Bascom flap reconstruction following wide excision of pilonidal sinus disease. World J Colorectal Surg. 2023;12(4):78-82.
37. Lin W, Wee IJY, Seow-En I, Chok AY, Tan EKW. Survival outcomes with salvage surgery in watch and wait approach for rectal cancer with complete clinical response after neoadjuvant chemotherapy: a systematic review and meta-analysis. Ann Coloproctol. 2023;39(6):447-456.
38. Lin W, Yoon S, Zhao Y, Seow-En I, Chok AY, Tan EKW. Patient-reported unmet supportive care needs in long-term colorectal cancer survivors after curative treatment in an Asian population. Asian J Surg. 2023 Aug 31. doi: 10.1016/j.asjsur.2023.08.108.
39. Yee FZY, Ng YYR, Chok AY, Tan EKW, Seow-En I. Charity colonoscopy event and fund in Singapore: a novel method to raise awareness of colorectal cancer screening. World J Colorectal Surg. 2023;12(3):65-68.
40. Seow-En I, Li KK, Khor SN, Tan EK. Laparoscopic sigmoid colectomy with transanal natural orifice specimen extraction for sigmoid volvulus — a video vignette. Colorectal Dis. 2023 Aug;25(8):1746-1747. doi: 10.1111/codi.16671. PMID: 37469137.
41. Shannon NB, Seow-En I, Tan EK. Cost-effectiveness comparison of delayed versus immediate coloanal anastomosis following ultralow anterior resection for rectal cancer. ANZ J Surg. 2023 Apr;93(4):963-969. doi: 10.1111/ans.18148. PMID: 36358002.
42. Seow-En I, Khor SN, Zhao Y, Ng YYR, Tan EJKW. Real-time artificial intelligence-assisted colonoscopy and the effect of endoscopist experience on polyp detection rates at a tertiary referral centre. World J Colorectal Surg. 2023;12(3):59-64.
43. Seow-En I, Seow-Choen F. Warm water irrigation is useful for the identification of a bleeding colonic diverticulum. Clin Endosc. 2023;56(5):671-673. doi: 10.5946/ce.2022.279.
44. Seow-En I, Khor SN, Koo CH, Wee IJY, Tan EK. Transvaginal natural orifice specimen extraction (NOSE) in laparoscopic colorectal cancer surgery with new insights on technique and patient selection. Surg Laparosc Endosc Percutan Tech. 2023 Oct;33(5):571-575. doi: 10.1097/SLE.0000000000001208.
45. Seow-En I, Li KK, Khor SN, Tan EJKW. Three-port laparoscopic splenic flexure colectomy for descending colon cancer with intracorporeal colocolic anastomosis and transvaginal natural orifice specimen extraction. Videoscopy. 2023 Jul. doi: 10.1089/vor.2023.0004.
46. Koo CH, Chok AY, Wee IJY, Seow-En I, Zhao Y, Tan EJKW. Effect of preoperative oral antibiotics and mechanical bowel preparation on prevention of surgical site infection in elective colorectal surgery, and does oral antibiotic regime matter? A Bayesian network meta-analysis. Int J Colorectal Dis. 2023;38(1):151. doi: 10.1007/s00384-023-04444-3.
47. Zheng V, Wee IJY, Abdullah HR, Tan S, Tan EKW, Seow-En I. Same-day discharge (SDD) versus standard enhanced recovery after surgery (ERAS) protocols for major colorectal surgery: a systematic review. Int J Colorectal Dis. 2023;38(1):110. doi: 10.1007/s00384-023-04408-7.
48. Chen HLR, Seow-En I, Chok AY, Ngo NT, Cheng TL, Tan KE. The role of magnetic resonance tumour regression grade in the prediction of regression and survival of rectal adenocarcinoma after long-course chemoradiotherapy: a cohort study. Ann Med Surg (Lond). 2023;85(4):842-848. doi: 10.1097/MS9.0000000000000441.
49. Lam KK, Low YS, Lo M, Wong M, Leong Tang C, Tan E, Chok AY, Seow-En I, Wong SH, Cheah PY. KRAS-specific antibody binds to KRAS protein inside colorectal adenocarcinoma cells and inhibits its localization to the plasma membrane. Front Oncol. 2023 Mar;13:1036871. doi: 10.3389/fonc.2023.1036871.
50. Wee IJY, Koo CH, Seow-En I, Ng YYR, Lin W, Tan EJK. Laser hemorrhoidoplasty versus conventional hemorrhoidectomy for grade II/III hemorrhoids: a systematic review and meta-analysis. Ann Coloproctol. 2023;39(1):3-10. doi: 10.3393/ac.2022.00598.0085.
51. Seow-En I, Lin W, Chen LR, Tan EK. Three-port laparoscopic anterior resection for sigmoid cancer with transanal natural orifice specimen extraction (NOSE) and single-stapling colorectal anastomosis. Tech Coloproctol. 2023;27(8):695-696. doi: 10.1007/s10151-022-02736-4.
52. Seow-En I, Tan EK. Modified suction connecting tubing: a simple and cost-effective method of smoke evacuation during transanal total mesorectal excision — a video vignette. Colorectal Dis. 2023;25(5):1054-1055. doi: 10.1111/codi.16437.
53. Seow-En I, Koh YX, Tan EK. Transanal natural orifice specimen extraction following combined laparoscopic anterior resection and liver resection. Dis Colon Rectum. 2023;66(5):e216-e217. doi: 10.1097/DCR.0000000000002610.
54. Seow-En I, Ng YY, Tan IBH, Tan EK. Transanal total mesorectal excision and delayed coloanal anastomosis without stoma for low rectal cancer. Tech Coloproctol. 2023 Jan;27(1):75-81. doi: 10.1007/s10151-022-02677-y. PMID: 36029385.
55. Seow-En I, Koh YX, Tan EK. Transvaginal natural orifice specimen extraction following laparoscopic combined D3 right hemicolectomy and liver resection. Dis Colon Rectum. 2022;65(12):e1070-e1071. doi: 10.1097/DCR.0000000000002440.
56. Seow-En I, Chen LR, Li YX, Zhao Y, Chen JH, Abdullah HR, Tan EK. Outcomes after natural orifice extraction vs conventional specimen extraction surgery for colorectal cancer: a propensity score-matched analysis. World J Clin Oncol. 2022 Oct;13(10):789-801. doi: 10.5306/wjco.v13.i10.789. PMID: 36337314; PMCID: PMC9630998.
57. Ng WKD, Chok AY, Ng YY, Seow-En I, Tan EK. Efficacy of biofeedback therapy for faecal incontinence in an Asian population. ANZ J Surg. 2023 May;93(5):1262-1266. doi: 10.1111/ans.18131.
58. Seow-Choen F, Seow-En I. Pilonidal disease: a new look at an old disease. Semin Colon Rectal Surg. 2022 Aug;33(3):100909. doi: 10.1016/j.scrs.2022.100909.
59. Joanito I, Wirapati P, Zhao N, Nawaz Z, Yeo G, Lee F, Eng CLP, Macalinao DC, Kahraman M, Srinivasan H, Lakshmanan V, Verbandt S, Tsantoulis P, Gunn N, Venkatesh PN, Poh ZW, Nahar R, Oh HLJ, Loo JM, Chia S, Cheow LF, Cheruba E, Wong MT, Kua L, Chua C, Nguyen A, Golovan J, Gan A, Lim WJ, Guo YA, Yap CK, Tay B, Hong Y, Chong DQ, Chok AY, Park WY, Han S, Chang MH, Seow-En I, Fu C, Mathew R, Toh EL, Hong LZ, Skanderup AJ, DasGupta R, Ong CJ, Lim KH, Tan EKW, Koo SL, Leow WQ, Tejpar S, Prabhakar S, Tan IB. Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer. Nat Genet. 2022 Jul;54(7):963-975. doi: 10.1038/s41588-022-01100-4. PMID: 35773407; PMCID: PMC9279158.
60. Seow-En I, Koo CH, Chen LR, Tan EK. 3-port laparoscopic D3 right hemicolectomy with transvaginal natural orifice specimen extraction — a video vignette. Colorectal Dis. 2022;24(7):880-881.
61. Seow-En I, Khor SN, Tan KW. Laparoscopic 3-port anterior resection with transvaginal natural orifice specimen extraction (NOSE) in a patient with a high BMI: a video vignette. Colorectal Dis. 2022 Nov;24(11):1443-1444. doi: 10.1111/codi.16213. PMID: 35662379.
62. Seow-En I, Chen WT. Complete mesocolic excision with central venous ligation/D3 lymphadenectomy for colon cancer — a comprehensive review of the evidence. Surg Oncol. 2022;42:101755.
63. Chua D, Loh AH, Tan E, Seow-En I. Perivascular epithelioid cell tumour (PEComa): an unusual cause of painful defaecation. BMJ Case Rep. 2022 Feb;15(2):e247686. doi: 10.1136/bcr-2021-247686.
64. Shaw MYV, Asokkumar R, Tan EJ, Seow-En I. Colonic angiodysplasia: a culprit of obscure gastrointestinal bleeding in a patient with Heyde syndrome. BMJ Case Rep. 2022 Jan;15(1):e247595. doi: 10.1136/bcr-2021-247595.
65. Seow-En I, Tan YG, Tay KJ. Laparoscopic sphincter-preserving total pelvic exenteration with transanal total mesorectal excision for locally advanced rectal cancer — a video vignette. Colorectal Dis. 2022 Apr;24(4):542-543. doi: 10.1111/codi.16011. PMID: 34856065.
66. Seow-En I, Chok AY, Tan EK. Transanal total mesorectal excision with two-stage Turnbull-Cutait pull-through for delayed low anastomotic leakage — a video vignette. Colorectal Dis. 2022 Mar;24(3):331-332. doi: 10.1111/codi.15993. PMID: 34796602.
67. Asokkumar R, Seow I, Chin Hong L, Chang J, Tan D, Salazar E. Rostered routine testing for severe acute respiratory coronavirus virus 2 infection among healthcare workers: do we detect more? J Gastroenterol Hepatol. 2021 Oct 25. doi: 10.1111/jgh.15720. PMID: 34694645.
68. Chang SC, Seow-En I, Ke TW, Chen HC, Chen YC, Tsai YY, Wang HM, Chen WT. Laparoscopic total pelvic peritonectomy for colorectal cancer pelvic carcinomatosis: a retrospective case series and photographic/videographic step-by-step guide. Surg Endosc. 2022 Mar;36(3):2178-2191. doi: 10.1007/s00464-021-08719-0. PMID: 34494157.
69. Seow-En I, Chok AY, Matchar DB, Yoon S, Chong DQ, Tan EK. Long-term quality of life, sexual health and gastrointestinal function following colorectal cancer resection in an Asian cohort. Colorectal Dis. 2021;23:2348-2360. doi: 10.1111/codi.15768.
70. Seow-En I, Ke TW, Chen YC, Chen WTL. A combined abdominal and transanal minimally invasive (TAMIS) approach in redo anastomoses for severe refractory rectal strictures. Colorectal Dis. 2021 May;23(5):1258-1261.
71. Seow-En I, Chang SC, Ke TW, Shen MY, Chen HC, Chen WTL. Uncomplicated sigmoid volvulus is ideal for laparoscopic sigmoidectomy with transrectal natural orifice specimen extraction. Dis Colon Rectum. 2021 May;64(5):e90-e93.
72. Seow-En I, Ke TW, Chang SC, Chen WT. Laparoscopic retrojejunal trans-mesenteric anastomosis for extended left-sided colorectal resections — a new solution to an old problem. Colorectal Dis. 2021 May;23(5):1262-1267.
73. Seow-En I, Wu J, Yang LWY, Tan JSQ, Seah AWH, Foo FJ, Chang M, Tang CL, Tan EKW. Results of a colorectal enhanced recovery after surgery (ERAS) programme and a qualitative analysis of healthcare workers' perspectives. Asian J Surg. 2020 Aug 27:S1015-9584(20)30246-3.
74. Seow-En I, Seow-Choen F. Comment on: transanal total mesorectal excision for rectal cancer has been abandoned in Norway. Br J Surg. 2020 Jun;107(7):e223.
75. Seow-En I, Tan WJ, Dorajoo SR, Soh SHL, Law YC, Park SY, Choi GS, Tan WS, Tang CL, Chew MH. Prediction of overall survival following colorectal cancer surgery in elderly patients. World J Gastrointest Surg. 2019 May;11(5):247-260.
76. Seow-En I, Seow-Choen F. An initial experience comparing robotic total mesorectal excision (RTME) and transanal total mesorectal excision (TaTME) for low rectal tumours. Ann Acad Med Singapore. 2018 May;47(5):188-190.
77. Seow-En I, Hwarng G, Tan GHC, Ho LML, Teo MCC. Palliative surgery for Krukenberg tumors — 12-year experience and review of the literature. World J Clin Oncol. 2018 Feb;9(1):13-19.
78. Seow-En I, Seow-Choen F, Koh PK. An experience with video-assisted anal fistula treatment (VAAFT) with new insights into the treatment of anal fistulae. Tech Coloproctol. 2016 Apr 8. doi: 10.1007/s10151-016-1456-3.
79. Seow-En I, Seow-Choen F. A prospective randomised trial on the use of Coca-Cola Zero® versus water for polyethylene glycol bowel preparation before colonoscopy. Colorectal Dis. 2015 Dec 18. doi: 10.1111/codi.13235.
80. Seow-En I, Loh AH, Lian DW, Nah SA. Thyroglossal duct cyst carcinoma: diagnostic and management considerations in a 15-year-old with a large submental mass. BMJ Case Rep. 2015 Jul;2015. doi: 10.1136/bcr-2015-210003.
81. Seow-En I, Seow-Choen F. Intestinal type gastric adenocarcinoma with unusual synchronous metastases to the colorectum and bladder. World J Clin Cases. 2015 Jun;3(6):533-537.
82. Seow-En I, Seow-Choen F. Anorectal reconstruction using graciloplasty after abdominoperineal resection — a review of the current literature and recommendations for the future. Acta Chir Iugosl. 2014;61(2):39-45.
83. Seow-En I, Ngu J. Routine operative swab cultures and post-operative antibiotic use for uncomplicated perianal abscesses are unnecessary. ANZ J Surg. 2014 Nov 21. doi: 10.1111/ans.12897.
84. Seow-En I, Seow-Choen F, Lim TK, Leow WQ. Primary omental gastrointestinal stromal tumour (GIST) presenting with a large abdominal mass and spontaneous haemoperitoneum. BMJ Case Rep. 2014 Nov;2014. doi: 10.1136/bcr-2014-205724.
85. Seow-En I, Seow-Choen F. Sigmoid volvulus treated by mini-incision. Tech Coloproctol. 2014 Dec;18(12):1169-1171.
86. Seow-En I, Foo FJ, Tang CL. Jejunojejunal intussusception secondary to submucosal lipoma resulting in a 5-year history of intermittent abdominal pain. BMJ Case Rep. 2014 Oct;2014. doi: 10.1136/bcr-2014-205285.
87. Seow-En I, Chiow AK, Tan SS, Poh WT. Eosinophilic cholangiopathy: the diagnostic dilemma of a recurrent biliary stricture — should surgery be offered for all? BMJ Case Rep. 2014 Jan;2014. doi: 10.1136/bcr-2013-202059.
88. Seow-Choen F, Seow-En I. Martius flap for ano-vaginal fistula: a photographic step-by-step guide. Tech Coloproctol. 2013 Aug;17(4):467-468.
89. Seow-En I, Daud MA, Seow-Choen F. The umbilicus as a site for defunctioning ileostomies. Tech Coloproctol. 2011 Jun;15(2):213-214.
90. Seow-En I, Tan KY, Mohd Daud MA, Seow-Choen F. Traditional laparoscopic colorectal resections can be performed effectively using a three-port technique. Tech Coloproctol. 2011 Mar;15(1):91-93.
91. Seow-En I, Seow-Choen F, Tseng PT. Prior uterine perforation resulting in intestinal obstruction in a subsequent pregnancy. Tech Coloproctol. 2010 Dec;14(4):369.

II. Book Chapters

1. Seow-En I, Shen MY, Chen WTL. Transanal minimally invasive surgery and transanal total mesorectal excision. In: Garg HP, Agarwalla R, Ramesh M, Kumar A, Lakshmi K, eds. Textbook of Laparoscopic, Endoscopic and Robotic Surgery: Two Volume Set. Jaypee Brothers Medical Publishers; 2024. ISBN 978-9356965621.
2. Seow-En I, Chen WTL. Laparoscopic abdominoperineal resection. In: Lomanto D, Chen WTL, Fuentes MB, eds. Mastering Endo-Laparoscopic and Thoracoscopic Surgery. Springer Singapore; 2023. https://ddei5-0-ctp.trendmicro.com:443/wis/clicktime/v1/query?url=https%3a%2f%2fdoi.org%2f10.1007%2f978%2d981%2d19%2d3755%2d2%5f72&umid=D4287162-5351-5F06-B280-F557581864D9&auth=47c05c838325d75a419a880435ac0d2beef06415-dc20e20c018ed5c915f463b259d6b8da2de61f69.
3. Seow-En I, Kwong-Wei E, Chen WL. Laparoscopic ventral mesh rectopexy. In: Lomanto D, Chen WTL, Fuentes MB, eds. Mastering Endo-Laparoscopic and Thoracoscopic Surgery. Springer Singapore; 2023. https://ddei5-0-ctp.trendmicro.com:443/wis/clicktime/v1/query?url=https%3a%2f%2fdoi.org%2f10.1007%2f978%2d981%2d19%2d3755%2d2%5f74&umid=D4287162-5351-5F06-B280-F557581864D9&auth=47c05c838325d75a419a880435ac0d2beef06415-8f1e5923709ed136f0386fb7d4ebaac9caa2447d.
4. Seow-En I, Tsai YY, Chen WTL. Laparoscopic parastomal hernia repair. In: Lomanto D, Chen WTL, Fuentes MB, eds. Mastering Endo-Laparoscopic and Thoracoscopic Surgery. Springer Singapore; 2023. https://ddei5-0-ctp.trendmicro.com:443/wis/clicktime/v1/query?url=https%3a%2f%2fdoi.org%2f10.1007%2f978%2d981%2d19%2d3755%2d2%5f68&umid=D4287162-5351-5F06-B280-F557581864D9&auth=47c05c838325d75a419a880435ac0d2beef06415-2c6cd537a1e83b9c1e5f9f4b7ca8124518fd7f6b.
5. Seow-En I, Seow-Choen F. Utility of marsupialisation following anal fistula surgery. In: Ratto C, Parello A, Litta F, De Simone V, Campennì P, eds. Anal Fistula and Abscess. Coloproctology. Springer Cham; 2021. https://ddei5-0-ctp.trendmicro.com:443/wis/clicktime/v1/query?url=https%3a%2f%2fdoi.org%2f10.1007%2f978%2d3%2d030%2d30902%2d2%5f22%2d1&umid=D4287162-5351-5F06-B280-F557581864D9&auth=47c05c838325d75a419a880435ac0d2beef06415-6c010542f9da38f34f9e613b6facba278c339985.
6. Seow-Choen F, Seow-En I. Technical tips and tricks of hemorrhoidectomy. In: Ratto C, Parello A, Litta F, eds. Hemorrhoids. Coloproctology, vol 2. Springer Cham; 2018. https://ddei5-0-ctp.trendmicro.com:443/wis/clicktime/v1/query?url=https%3a%2f%2fdoi.org%2f10.1007%2f978%2d3%2d319%2d53357%2d5%5f22&umid=D4287162-5351-5F06-B280-F557581864D9&auth=47c05c838325d75a419a880435ac0d2beef06415-1782a0e7d4473908111566e9e0f42e0a3051fab9.
7. Seow-En I, Seow-Choen F. Surgical considerations prior to colorectal cancer surgery. In: Colorectal Cancer in the Elderly. 2012:47-55.