Our vision is to build and sustain a dynamic ecosystem of high impact research in blood, breast, colorectal and prostate cancer, with novel methods for early detection, unravelling of the tumour microenvironment and its inflammatory milieu, translating to targeted therapeutics for quality survival, supported by robust registries and tissue repositories, to be achieved in the next 5 years.
Key outcome: Early screening service in SGH where biomarker based assays in leukaemia, breast, colon and prostate cancer allow earlier and more accurate detection of cancer than current approaches.
Colon: predicting cancer
Prostate: improving diagnostic precision
Breast: better than mammogram
Interpreting changes in the tumour microenvironment during routine diagnostic pathology in the era of cancer immunotherapy.
Integrate parameters of tumour and immune microenvironment (TIME) into prognostic and therapeutic models.
Aim 1: Examine how the molecular and cellular nature of the tumour immune microenvironment (TIME) influence cancer development and therapy (eg. dysfunctional signaling, chronic inflammation, etc).
Aim 2: Investigating the biological nature of T-cells (innate or adoptively infused) within the TIME and their ability to successfully reject tumours as a prognostic capability.
Development of robust platforms at SGH for supporting the delivery of targeted therapies that are oncologically efficacious, have minimal side effects, and allow patients to maintain their quality of life.
Such platforms include: Imaging and molecular guidance systems and preclinical animal models.
Aim 1: Identify targets for therapy.
Aim 2: Develop therapeutic approaches to attack these targets.
Aim 3: Develop predictive biomarkers in order to select suitable patients for targeted therapy.
Exercise in Cancer
Prof Tan Puay HoonSpecialty: PathologySub-specialty: Histopathology, Cytology
Chairman, Division of PathologySenior ConsultantAnatomical PathologySingapore General Hospital
Assoc Prof Charles Chuah Specialty: HaematologySub-specialty: Acute Leukemia
Senior ConsultantHaematologySingapore General Hospital
Senior ConsultantSingHealth Duke-NUS Blood Cancer Centre
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