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Drug Class: Commonly Known As: Category:
Levofloxacin, Fluoroquinolones

Levofloxacin - Side Effects, Precautions, and Contraindications

What side effects can Levofloxacin cause?

Commom side effects include:
Oral tablets

  • Nausea, vomiting or loss of appetite
    • Eat mild tasting food, and avoid rich or spicy meals.
    • Take this medication after meals.
  • Diarrhoea
    • Drink plenty of water with oral rehydration salts to replenish your fluids and electrolytes.
    • Speak to your healthcare professional if the diarrhoea is severe or bloody.
  • Dizziness
    • Rest, and wait for it to go away  before resuming daily activities.
    • Avoid driving or operating machinery if affected.
  • Increased sensitivity to sunlight
    • Apply sunblock, wear long sleeves and trousers, and avoid being exposed to direct sunlight especially during the hottest time of the day.

      Eye preparations
  • Temporary blurring of vision after use
    • Do not drive or operate machinery until you can see clearly again.

Rare but serious side effects include:

  • Painful swelling of the joints or tendons
  • Sudden chest, stomach or back pain
  • Burning, tingling or numbing sensations or muscle pain/weakness
  • Changes in behaviour, attention or thinking
  • Seizures (fits)
  • Drug allergy-symptoms may include swollen face/eyes/lips/tongue, difficulty in breathing or skin rashes over your whole body

 If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Levofloxacin , what precautions must I follow?

​Inform your healthcare professional if:

  • You have any other medical conditions such as:
    • Epilepsy (fits or seizures)
    • Myasthenia gravis (a long-term immune condition that causes muscle weakness)
  • You are allergic to this medication or any of the other ingredients of this medication
  • You are pregnant, planning to become pregnant, or breastfeeding
  • You are taking any other medications, including supplements, traditional medications and herbal remedies
  • You have existing heart problems or are on any medicine that regulates your heartbeat
  • You have glucose-6-phosphate dehydrogenase (G6PD) deficiency

What food or medicine must I avoid when I take Levofloxacin ?

Oral tablets

Avoid consuming the following foods or medications together with Levofloxacin:

  • Milk-containing products or dairy products (e.g. milk feeds)
  • Indigestion remedies (e.g. Antacids)
  • Medicines (e.g. Sucralfate) or supplements that contain aluminium, calcium, iron, magnesium or zinc.
  • Medicines that acts as binders (e.g. Lanthanum, Sevelamer)

    You should take the above products 2 hours before or after Levofloxacin as taking them together reduces the absorption of Levofloxacin into your body.

    Certain medications may increase the risk of side effects of Levofloxacin if taken together with Levofloxacin. These medications are (but not limited to):
  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Theophylline
  • Cyclosporine
  • Probenecid

    Consult your healthcare professional if you can continue taking them with Levofloxacin.

Levofloxacin - Additional Information


  • Updated on 7/31/2021 12:00:00 AM
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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