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Clomiphene

Drug Class: Commonly Known As: Category:
Antiestrogen Clomid Adult

Clomiphene - Side Effects, Precautions, and Contraindications

What side effects can Clomiphene cause?

Common side effects include:

  • Bloating, nausea and/or vomiting
    • Take the medication after food to reduce these side effects.
  • Hot flushes
    • Wear loose fitting clothes or go to areas with air-conditioning.
  • Dizziness/light-headedness and tiredness
    • Avoid activities that require mental alertness and avoid using heavy machinery.
  • Headache, muscle aches or joint pains
    • You may take paracetamol to relieve such symptoms.

Rare but serious side effects include blood clot formation. However, blood clot formation is rare and the doctor would have evaluated and weighed its benefits over risks before making the recommendation.

The symptoms of blood clot include one or more of the following

  • Any unusual sudden cough, breathlessness or difficulty in breathing
  • Severe pain in the chest which may reach the left arm
  • Severe pain in legs or swelling in either of your legs
  • Weakness or numbness in any part of your body
  • Change in your speech, including slurring of words
  • Change in your senses of hearing, smell or taste
  • Vision changes such as loss of vision/blurred vision/spots/flashes

Other rare but serious side effects that you may or may not experience:

  • Dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin
  • Ovaries get more stimulated, which can cause very bad stomach pain
  • Sudden and severe headaches

The symptoms of a drug allergy include one or more of the following

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Clomiphene, what precautions must I follow?

​Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You are pregnant or breastfeeding (ensure negative urine pregnancy test before taking this medication)
  • You have or ever had liver disease
  • You have hormone dependent tumour or abnormal uterine bleeding
  • You have an ovarian cyst (except polycystic ovary)
  • You are taking any other medications, including supplements, traditional medications and herbal remedies

What food or medicine must I avoid when I take Clomiphene?

Clomiphene - Additional Information

  • Updated on Wednesday, July 31, 2019
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup

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