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Chlorambucil

Drug Class: Commonly Known As: Category:
Alkylating Agent Leukeran® Cancer-related

Chlorambucil - Side Effects, Precautions, and Contraindications

What side effects can Chlorambucil cause?

  • Nausea and vomiting
  • Diarrhea
  • Mouth sores
  • Changes in menstrual cycle (for women)
  • Decreased white and red blood cells, platelets
  • Tiredness and lack of energy may occur
    Do not drive a car or operate machinery. Avoid alcohol as it may make you feel more tired and drowsy.
  • Changes in the menstrual cycle for women
  • Numbness or tingling in hands or feet

Inform your doctor if any of the following occurs:

  • Fever of 38 ˚C or higher
  • Severe ulcers or sores in the mouth and throat
  • Unusual bruising, bleeding or black sticky stools
  • Sudden or gradual onset of cough, shortness of breath
  • Pain or difficulty in urinating
  • Seizures
  • Yellowing of the eye whites and skin or dark tea-coloured urine
  • Allergic reaction e.g. rash, swelling of eyelids and face

Before taking Chlorambucil, what precautions must I follow?

  • Effective birth control should be used while taking Chlorambucil. Inform your doctor if you or your partner plan for or suspect pregnancy.
  • To minimize infection risk, wash your hands after using the toilet and before handling food, and take precaution when visiting crowded places or being around sick people.

What food or medicine must I avoid when I take Chlorambucil?

Chlorambucil - Additional Information

  • Updated on Wednesday, March 6, 2019
  • Article contributed by Department of Pharmacy National Cancer Centre Singapore

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