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Antimalarial

Drug Class: Commonly Known As: Category:
Antimalarial Adult, Children

Antimalarial - Dosage and How to Use

How should Antimalarial be used?

Mefloquine (available at retail pharmacies)

Start two to three weeks before departure, continue to take the medication once a week during travel and continue once a week for 4 weeks after leaving endemic area.

Adult dose ( Weight >45kg )
  • One 250mg tablet once a week, on the same day of the week.
  • Check with your pharmacist or doctor for the correct dose if your weight is 45 kg or lower.

Paediatric dose (Applies to children age ≥6 months and weight >5 kg)

​Body Weight Dose​
​20-30kg​125mg (1/2 of 250mg tablet) once weekly
​30-45kg​187.5mg (3/4 of 250mg tablet) once weekly
​>45kg​250mg once weekly

 

Administration

  • Take with or after food and with at least one full glass of water.
  • The tablets may be crushed and suspended in a small amount of water, milk or other beverage for administration to people unable to swallow them whole.
  • If you vomit within 30 minutes of administration, repeat the dose.​

Atovaquone with Proguanil (Malarone®)(requires a doctor's prescription)

  • Start one to two days before departure; continue to take the medication every day during the trip and for one week upon your return from endemic area.

Adult dose

  • One tablet once a day
​Body weight  ​Dose
​11-20kg ​1 tablet (62.5 mg/25 mg) once a day  
​21-30kg​2 tablets (125 mg/50 mg) once a day  
​31-40kg​3 tablets (187.5 mg/75 mg) once a day  
​>40kg​4 tablets (250 mg/100 mg) once a day  ​

        

Administration

  • ​Take the daily dose with or after food or a milky drink at the same time each day.
  • Tablets may be crushed and suspended in a small amount of water, milk, or another beverage for persons unable to swallow tablets.
  • If you vomit within 1 hour of administration, repeat the dose.

Doxycycline (requires a doctor's prescription)

  • ​Start one to two days before departure; continue to take every day during the trip and for four weeks upon your return from endemic area.

Adult dose

  • 100mg once a day

Paediatric dose (Applies to children age> 8 years)

  • 2.2mg/kg dose once a day, up to a maximum of 100mg per dose

​Administration

  • ​Take with a full glass of water and avoid lying down for about 30 minutes after taking this medication.
  • Space doxycycline capsules one hour before or 2 hours after taking antacids and preparations containing calcium, iron and zinc.
  • If gastric irritation occurs, take this medication with food or milk.

Chloroquine (available at pharmacies)

  • Start one week before departure and continue to take every week during the trip and for four weeks upon your return.

Adult dose

  • Two 250mg tablets once a week (Total 300mg base), on the same day of the week.

Pediatric dose (according to weight)

  • 5 mg base/kg (8.3mg/kg salt), once a week on the same day each week. (Do not to exceed 300mg base/dose)

Administration

  • Take with or after food to decrease gastric side effects and bitter aftertaste.

What should I do if I miss a dose?

What should I do if I overdose?

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