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Cranial and Peripheral Neurovasculopathies Research Program

Together with clinical, neurological and dental partners, the team is experienced in using high-resolution heavily T2-weighted 3D MRI, multiband accelerated RESOLVE DTI and MR neurography in the evaluation of neurovascular conflicts of the facial and trigeminal nerves, and neuropathies affecting the extracranial trigeminal nerve and brachial and lumbosacral plexopathies.


Please contact A/Prof Chan Ling Ling and Dr Robert Chen for more information.


  1. Chan LL, Tan EK. Neurovascular compression in hemifacial spasm. Brain. Published online September 16, 2021. doi:10.1093/brain/awab338

  2. Koh YH, Shih YC, Lim SL, Kiew YS, Lim EW, Ng SM, Ooi LQR, Tan WQ, Chung YC, Rumpel H, Tan EK, Chan LL. Evaluation of trigeminal nerve tractography using two-fold-accelerated simultaneous multi-slice readout-segmented echo planar diffusion tensor imaging. Eur Radiol. 2021 Feb;31(2):640-649. doi: 10.1007/s00330-020-07193-x.

  3. Lim KC, Santhosh RS, Kee TP, Sim S, Ho MI, Ho JXM, Mcadory LE, Lim WEH, Chan LL. Cryptic Asymptomatic Parasellar High Signal on Time-of-Flight MR Angiography: How to Resolve the Clinical Conundrum. Neuroradiology 2020 Jul 26. doi: 10.1007/s00234-020-02482-0. 

  4. Gupta A, Lee ECH, Kelly HR, Chen RC. Clinical and imaging manifestations of trochlear nerve schwannomas—a case series. Journal of Neuro-Ophthalmology. 2020; doi:10.1097/WNO.0000000000001059

  5. Chen RC, Kheok SW, Salkade PR, Chan LL, Choy G, Tow S. Compressive Optic Neuropathy from the Normal and Abnormal Carotid Artery. Neurographics 2018 Apr 1;8(2):79-85.

  6. Edmond EC, Sim SX, Li HH, Tan EK, Chan LL. Vascular tortuosity in relationship with hypertension and posterior fossa volume in hemifacial spasm. BMC Neurol. 2016 Jul 29;16:120. doi: 10.1186/s12883-016-0634-z. 

  7. Leong JL, Li HH, Chan LL, Tan EK. Revisiting the link between hypertension and hemifacial spasm.  Sci Rep. 2016 Feb 19;6:21082. doi: 10.1038/srep21082.

  8. Chan LL, Ng KM, Fook-Chong S, Lo YL, Tan EK. Three-dimensional MR volumetric analysis of the posterior fossa CSF space in hemifacial spasm.  Neurology. 2009 Sep 29;73(13):1054-7.

  9. Chan LL, Lee E, Fook-Chong S, Tan EK.  Case control MR-CISS and 3D TOF MRA imaging study of medullary compression and hypertension in hemifacial spasm.  Mov Disord 2008 15;23(13):1820-4.

  10. Chan LL, Lo YL, Lee E, Fook-Chong S, Tan EK. Ventrolateral medullary compression in hypertensive patients with hemifacial spasm. Neurology 2005;65(9):1467-70.

  11. Tan EK, Chan LL.  A controlled MRI/A study of neurovascular contact in hemifacial spasm. Neurology 2000;55:155-156

  12. Tan EK, Lim SH, Chan LL, Wong ZW.  Trigeminal neuralgia: should MRI be done routinely? Australia and New Zealand Journal of Medicine 1998;28:827-829