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Home Research & Innovation Enablers Pathological Sciences

Pathological Sciences

Synonym(s):

Spurring Medical Discoveries through Pathological Sciences

Pathological Sciences involves the study and analysis of diseases through examination of tissues, cells, and body fluids. The Pathological Sciences team at Singapore General Hospital (SGH) specialises in advanced pathology techniques and analysis.

Our comprehensive research infrastructure supports breakthrough discoveries in medical science through advanced technology and expert analysis. View pathological laboratory services for more information about our services.

Research Capabilities

Our technical expertise spans six key areas that are classified in two broad categories.

Advanced Imaging and Analysis

  • Multiplex immunohistochemistry/immunofluorescence (mIHC/IF)
  • Digital Pathology with Whole Slide Imaging
  • Laser Capture Microdissection

Tissue Analysis and Sequencing

  • Tissue microarray (TMA) construction for biomarker discovery
  • Next Generation Sequencing (NGS)
  • T-cell Receptor Repertoire Sequencing

Projects

Rapier

The Radiology Pathology Information Exchange Resource (RAPIER) represents one of our key research initiatives. Through this project, our team has developed breakthrough solutions in medical imaging and pathology analysis.

Why It Matters

  • Bridges the gap between radiology and pathology data
  • Enables integrated analysis of medical imaging and tissue examination
  • Supports more accurate disease diagnosis and monitoring
  • Facilitates data-driven healthcare decisions

Innovation Benefits

  • Enhanced collaboration between radiologists and pathologists
  • Improved diagnostic accuracy through combined data analysis
  • Streamlined information exchange
  • More comprehensive patient care approach

SteatoStat

Our team has developed SteatoStat, an AI-driven tool that revolutionises the assessment of hepatic steatosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). This innovation addresses a growing global health concern by transforming conventional assessment methods.

Why It Matters

  • MASLD is a growing global health concern
  • Hepatic steatosis is crucial for diagnosis and disease monitoring
  • Traditional semi-quantitative grading methods face limitations in precision and consistency

Innovation Benefits

  • Accurate and consistent quantification
  • Efficient assessment times
  • Reduced inter- and intra-observer variability
  • Standardised and objective evaluation

Goals

We are advancing pathological sciences through three strategic initiatives:

1. TRAIL Development

  • Building capacity for the Translational Research and Innovation Lab (Including: Antibiotic Combination Testing (ACT), Antimicrobial Therapeutic Drug Monitoring (TDM), Multiplex IHC/IF and Germline Genetic Testing)
  • Establishing new research partnerships
  • Expanding research capabilities

2. Digital Innovation

  • Driving advancements in Digital Pathology
  • Developing AI solutions, including an AI Platform for Slide Quality Check in Histopathology
  • Implementing innovative diagnostic tools

 

3. Cancer Research in Cancer Peak projects

  • Head and neck cancer
  • Breast cancer
  • Colorectal cancer

 

Collaborate

Our team brings distinctive strengths to research collaborations:

Research Infrastructure

  • Comprehensive pathological research facilities
  • Advanced analytical capabilities
  • State-of-the-art equipment

Expert Team

  • Dedicated research staff
  • Experienced pathologists
  • Multidisciplinary expertise

Growth Potential

  • Expanding TRAIL facilities
  • Strong focus on translational research
  • Proven track record in innovation

Let's Connect!

 

Ready to be part of our transformative journey? 

Innovation waits for no one. Get in touch with us.

Contact Us

 
SGH Enablers

Health Services Research Unit (HSRU)

Optimizes healthcare delivery through evidence-based research and outcome studies

Clinical Innovation and Technology Unit (CITU)

Develops technological solutions to address clinical challenges in healthcare

Clinical Trials & Research Centre (CTRC)

Provides end-to-end support for clinical trials and research studies

Department of Clinical Translational Research (DCR)

Transforms laboratory discoveries into practical clinical treatments and applications

Biomechanics Lab

Studies movement science to improve patient rehabilitation and musculoskeletal care

Data Science and Artificial Intelligence Laboratory (DSAIL)

Applies AI and analytics to enhance healthcare delivery outcomes

Pathological Sciences

Advances disease diagnostics through innovative pathology research and methods

Radiological Sciences

Develops advanced imaging techniques for improved diagnosis and treatment

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    Outram Road, Singapore 169608

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