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Prof Tay Sun Kuie

Prof Tay Sun Kuie

​MBBS, FRCOG (UK), MD (Lond), FAMS, MAppLaw

Senior Consultant

Singapore General Hospital

Specialty: Surgery & Surgical Oncology, Obstetrics & Gynaecology

Clinical Interest: Obstetrics & Gynaecology, Endometriosis

Conditions Treated by this Doctor:
Cervical Cancer, Ovarian Cancer, Vaginal Cancer, Vulva Cancer.

Clinical Appointments

  • Senior Consultant Obstetrics & Gynaecology Singapore General HospitalSingapore General Hospital
  • Senior Consultant Division of Surgery & Surgical Oncology National Cancer Centre SingaporeNational Cancer Centre Singapore

Academic Appointments

  • Duke-NUS Medical School
  • NUS Yong Loo Lin School of Medicine


Professor Tay is a senior consultant Obstetrician and gynecologist providing a full range of gynaecological services encompassing conventional and minimally invasive surgeries, with special interests in gynaecological tumours and cancers, colposcopy and management of cervical screening abnormalities (positive Pap smear and HPV tests), and endometriosis.

Professor Tay graduated MBBS from University College London, UK and was awarded the Doctorate of Medicine (MD) by the University of London on a thesis entitled “Local Cervical Immune Reactions to Human Papillomavirus Infection and Its Associated Neoplasia”. His specialist training in obstetrics & gynaecology was completed in London where he also received subspecialty training in colposcopy and laser treatment of pre-invasive disease of the cervix by Professor Albert Singer PhD, Dphil (Oxon), FRCOG. He also took a fellowship of the Ministry of Health, Singapore for a special interest in immunotherapy of gynaecological cancer at the MD Anderson Medical Centre and Institute of Tumours, Houston, Texas, USA in 1993.  Professor Tay was admitted to the fellowship of the Academy of Medicine, Singapore (FAMS) in 1989 and the Royal College of Obstetricians and Gynaecologists London (FRCOG) in 1998. He was conferred Clinical Associate Professor by the Yong Loo Lin School of Medicine, National University of Singapore in 2000 and, later, Clinical Professor, at Duke-NUS Medical School. Prof Tay is a faculty member in the academic clinical program for training of residents in obstetrics and gynaecology. He is a medical educator and author of three books: “Cervical cancer: Its Causes and Prevention”, “Gynaecology Clinics Illustrated “, and “Hysterectomy for Benign Conditions”. He has also contributed chapters to many text books in gynaecology.

Professor Tay has a carrier-long research interest and clinical expertise in human papillomavirus infection and women’s cancer. He has published more than 110 research papers in peer reviewed medical and scientific journals.

Professor Tay has previously held positions of President, Society for Colposcopy and Cervical Pathology, Singapore and Associate Editor of Annals, Academy of Medicine Singapore. He has served as Chairman, Committee for Clinical Privileges and Credentialing, Singapore General Hospital, Director of Research, and member of Medical Board, Singapore General Hospital. He is also a qualified mediator serving as a court appointed volunteer mediator, States Courts of Singapore and Principal Mediator of Singapore Mediation Centre.


  • MBBS
  • FRCOG (UK)
  • MD (Lond)
  • FAMS
  • MAppLaw

Professional Appointments and Committee Memberships

  • Senior Consultant Obstetrician & Gynaecologist, Singapore General Hospital
  • Visiting Senior Consultant, National Cancer Centre Singapore
  • Clinical Associate Professor, Yong Loo Lin School of Medicine, National University of Singapore
  • Clinical Professor, Duke-NUS Medical School
  • Member, Complaints Committee, Singapore Medical Council
  • Principal Mediator, Singapore Mediation Centre
  • Volunteer Mediator, State Courts, Singapore


  • Hamilton & Bailey Prize in Surgery 1987 
  • National Science Award 1996
  • 16th Benjamin Sheares Memorial Lectureship 1997
  • Excellent Publication Award 1999
  • Review with Distinction Award, Singapore Medical Journal, 2005. 2006, 2008

Research Interests


  1. Tay SK, Hsu TY, Pavelyev A, Walia A, Kulkarni AS. Clinical and economic impact of school-based nonavalent human papillomavirus vaccine on women in Singapore: a transmission dynamic mathematical model analysis. BJOG. 2018 Mar;125(4):478-486. doi: 10.1111/1471-0528.15106. PMID: 29266694.
  2. Tay SK, Lee BW, Sohn WY, Lee IH, Mathur G, Sanicas M, Van Kriekinge G. Cost-effectiveness of two-dose human papillomavirus vaccination in Singapore. Singapore Med J. 2018 Jul;59(7):370-382. doi: 10.11622/smedj.2017085. Epub 2017 Oct 6. PMID: 28983579; PMCID: PMC6056373.
  3. Tay SK, Hsu TY, Shcheprov A, Walia A, Kulkarni AS. The clinical and economic benefits of school-based quadrivalent HPV vaccination in Singapore. Int J Gynaecol Obstet. 2017 May;137(2):129-137. doi: 10.1002/ijgo.12126. Epub 2017 Mar 10. PMID: 28190260.
  4. Tay SK, Lin LE, Goh RC. Detection Rate of High-Grade Cervical Neoplasia and Cost-Effectiveness of High-Risk Human Papillomavirus Genotyping with Reflex Liquid-based Cytology in Cervical Cancer Screening. Ann Acad Med Singap. 2017 Jul;46(7):267-273. PMID: 28821890.
  5. Tay K, Tay SK, Tesalona KC, Rashid NM, Tai EY, Najib SJ. Factors affecting the uptake of cervical cancer screening among nurses in Singapore. Int J Gynaecol Obstet. 2015 Sep;130(3):230-4. doi: 10.1016/j.ijgo.2015.03.037. Epub 2015 May 23. PMID: 26032624.
  6. Nin DS, Yew CW, Tay SK, Deng LW. Targeted silencing of MLL5β inhibits tumor growth and promotes gamma-irradiation sensitization in HPV16/18-associated cervical cancers. Mol Cancer Ther. 2014 Nov;13(11):2572-82. doi: 10.1158/1535-7163.MCT-14-0019. Epub 2014 Aug 29. PMID: 25172963.
  7. Tay SK, Cheong MA. Evidence for ethnic and environmental contributions to frequency of ovarian clear cell carcinoma. Aust N Z J Obstet Gynaecol. 2014 Jun;54(3):225-30. doi: 10.1111/ajo.12188. Epub 2014 Feb 19. PMID: 24888594.
  8. Tay SK, Oon LL. Prevalence of cervical human papillomavirus infection in healthy women is related to sexual behaviours and educational level: a cross-sectional study. Int J STD AIDS. 2014 Dec;25(14):1013-21. doi: 10.1177/0956462414528315. Epub 2014 Mar 19. PMID: 24648316.
  9. Chay WY, Chew SH, Ong WS, Busmanis I, Li X, Thung S, Ngo L, Lim SL, Lim YK, Chia YN, Koh E, Pang C, Soh LT, Wang J, Ho TH, Tay SK, Lim-Tan SK, Lim KH, Chia JW, Goh LK. HER2 amplification and clinicopathological characteristics in a large Asian cohort of rare mucinous ovarian cancer. PLoS One. 2013 Apr 19;8(4):e61565. doi: 10.1371/journal.pone.0061565. PMID: 23620766; PMCID: PMC3631219.
  10. Tay SK. Cervical cancer in the human papillomavirus vaccination era. Curr Opin Obstet Gynecol. 2012 Feb;24(1):3-7. doi: 10.1097/GCO.0b013e32834daed9. PMID: 22123221.
  11. Tan PS, Koh E, Pang C, Ong WS, Ngo L, Soh LT, Quek R, Chay WY, Ho TH, Tay SK, Chew SH, Lim-Tan SK, Khoo-Tan H, Lim SL, Busmanis I, Goh LK, Chia YN, Chia WK, Lim T. Uterine leiomyosarcoma in asian patients: validation of the revised Federation of gynecology and obstetrics staging system and identification of prognostic classifiers. Oncologist. 2012;17(10):1286-93. doi: 10.1634/theoncologist.2012-0124. Epub 2012 Jul 24. PMID: 22829569; PMCID: PMC3481894.
  12. Lee VJ, Tay SK, Teoh YL, Tok MY. Cost-effectiveness of different human papillomavirus vaccines in Singapore. BMC Public Health. 2011 Mar 31;11:203. doi: 10.1186/1471-2458-11-203. PMID: 21453537; PMCID: PMC3082243.
  13. Tay K, Tay SK. The impact of cytology screening and HPV vaccination on the burden of cervical cancer. Asia Pac J Clin Oncol. 2011 Jun;7(2):154-9. doi: 10.1111/j.1743-7563.2011.01396.x. PMID: 21585695.
  14. Yew CW, Lee P, Chan WK, Lim VK, Tay SK, Tan TM, Deng LW. A novel MLL5 isoform that is essential to activate E6 and E7 transcription in HPV16/18-associated cervical cancers. Cancer Res. 2011 Nov 1;71(21):6696-707. doi: 10.1158/0008-5472.CAN-11-1271. Epub 2011 Sep 9. PMID: 21908553.

Research Trials