Skip Ribbon Commands
Skip to main content
Dr Tan Hong Chang

Dr Tan Hong Chang


Senior Consultant

Singapore General Hospital

Specialty: Endocrinology

Clinical Interest: Diabetes, Obesity, Lipids Disorders

Conditions Treated by this Doctor:
Lipid disorders, Obesity, Type 2 Diabetes Mellitus.

Clinical Appointments

  • Director, Research SingHealth Duke-NUS Diabetes Centre
  • Senior Consultant Endocrinology Singapore General HospitalSingapore General Hospital


​Following the completion of my basic medical degree, I underwent basic specialist training in internal medicine and subsequently subspecialty training in endocrinology at Singapore General Hospital. I am also interested in clinical research. My research interest lies in the study of abnormalities in metabolic fuel regulation in various physiological and pathological states. I believe that the ability to manipulate how the body acquire, transport, integrate and utilize various nutrients is the key towards improving metabolic health. 


  • Masters of Clinical Investigation, NUS, 2016
  • MMed (Internal Medicine), NUS, 2007
  • MRCP, Royal College of Physician, 2007
  • MBBS, NUS, 2003

Professional Appointments and Committee Memberships

  • Clinical Lecturer, Yong Loo Lin School of Medicine
  • Adjunct Assistant Professor, Duke-NUS Graduate Medical School
  • Adjunct Principal Investigator, SingaHealth IMU
  • Program Lead for Pitch for Funds/Junior Pitch for Funds, Academic Medicine Program, SGH 
  • SGH Clinical Trials and Research Centre Advisory Board Member
  • SGH Research Executive Committee Member


  1. 18th ASEAN Federation of Endocrine Societies Congress, Winner (Oral Presentation, Obesity)
  2. 18th ASEAN Federation of Endocrine Societies Congress, 2nd Prize (Oral Presentation, Overall)
  3. MOH Healthcare Research Scholarship (2015)

Research Interests

  • Myelodysplastic Syndrome/Bone marrow failure syndromes
  • Haematopoietic Progenitor Cell Transplantation
  • Immune effector cell therapy


  • Higher Glycemic Exposure at the Time of Diagnosis of Diabetes after Kidney Transpant may be Associated with Reduced Patient Survival. Peng Chin Kek, Hong Chang Tan, Terence Yi Shern Kee, Su-Yen Goh, Yong Mong Bee. Journal of Diabetes Care & Endocrinology (2017). Accepted for publication. 

  • The diagnostic performance of the new ATA, BTA and TIRADS sonographic patterns on malignancy rate in histologically proven thyroid nodules. Chng CL, Tan HC, Too CW, Lim WY, Chiam PPS, Zhu L, Nadkarni NV, Lim AYY Singapore Medical Journal (2017). Accepted for publication 

  • Bariatric surgery is highly effective in preventing diabetes in high-risk Asian individuals. Singapore Medical Journal. Lee PC, Tan HC, Pasupathy S, Ganguly S, Eng AK, Nadkarni N, Tham KW. Singapore Medical Journal (2017). Accepted for publication 

  • The Effects of Sleeve Gastrectomy and Gastric Bypass on Branched-Chain Amino Acid Metabolism 1 Year After Bariatric Surgery.Tan, H. C., Meng Khoo, C., Tan, M. Z.-W., Kovalik, J.- P., Ng, A. C. M., Eng, A. K. H., et al. (2016). Obesity Surgery, 26(8), 1830–1835. 

  • Chng,C.-L.,Lim,A.Y.Y.,Tan,H.C.,Kovalik,J.-P.,Tham,K.W.,Bee,Y.M.,etal.(2016). Physiological and Metabolic Changes During the Transition from Hyperthyroidism to Euthyroidism in Graves' Disease. Thyroid : Official Journal of the American Thyroid Association, 26(10), 1422– 1430. 

  • Mother’s pre-pregnancy BMI is an important determinant of adverse cardiometabolic risk in childhood. Tan, H. C., Roberts, J., Catov, J., Krishnamurthy, R., Shypailo, R., & Bacha, F. (2015). Pediatric Diabetes, 16(6), 419–426. 

  • Metabolic bariatric surgery and type 2 diabetes mellitus: an endocrinologist's perspective. Ganguly, S., Tan, H. C., Lee, P. C., & Tham, K. W. (2015). Journal of Biomedical Research, 
29(2), 105–111. 
  • One year changes in QCT and DXA bone densities following bariatric surgery in a multiethnic 
Asian cohort. Tan, H. C., Tan, M., Tham, K. W., & Pasupathy, S. (2015). Osteoporosis and 
Sarcopenia. 1(2): 115–120. 

  • Studies of Molecular Mechanisms Associated With Increased Deiodinase 3 Expression in a Case of Consumptive Hypothyroidism. Aw, D. K. L., Sinha, R. A., Tan, H. C., Loh, L. M., Salvatore, D., & Yen, P. M. (2014). Journal of Clinical Endocrinology & Metabolism, 99(11), 3965–3971. 

  • Impact of bariatric surgery on the management of type 2 diabetes mellitus in Singapore.Lee, P. C., Tham, K. W., Tan, H. C., & Pasupathy, S. (2013). Singapore Medical Journal, 54(7), 382–386. 

  • Obesity: Prevention and management in youth/adults. Tan Hong Chang, Sonali Ganguly, Dr Tham Kwang Wei. Singapore Family Physician 2012 38(1): 23-2 

  • Oncogenic osteomalacia -- hypophosphataemic spectrum from "benignancy" to "malignancy". Chiam, P., Tan, H. C., Bee, Y. M., & Chandran, M. (2013). Bone, 53(1), 182–187. 

  • Day 1 post-operative fasting hyperglycemia may affect graft survival in kidney transplantation. Kek, P. C., Tan, H. C., Kee, T. Y. S., Goh, S. Y., & Bee, Y. M. (2013). Annals of Transplantation : Quarterly of the Polish Transplantation Society, 18, 265–272. 

  • Relationships between cholesterol efflux and high-density lipoprotein particles in patients with type 2 diabetes mellitus. Tan, H. C., Shyong Tai, E., Sviridov, D., Nestel, P. J., Ng, C., Chan, E., et al. (2011). Journal of Clinical Lipidology, 5(6), 467–473. 

  • Incidence and risk factors for development of new-onset diabetes after kidney transplantation. Bee, Y. M., Tan, H. C., Tay, T. L., Kee, T. Y., Goh, S. Y., & Kek, P. C. (2011). Annals of the Academy of Medicine, Singapore, 40(4), 160–167. 

Research Trials