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Clin Asst Prof Tan Ek Khoon

Clin Asst Prof Tan Ek Khoon



Specialty: Surgery & Surgical Oncology, Hepato-pancreato-biliary and Transplant Surgery

Sub-specialties: Hepato-pancreato-biliary and Transplant Surgery, Minimally Invasive Surgery, Transplantation

Conditions Treated by this Doctor:
Cholangiocarcinomas (bile duct cancer), Choledochal Cyst, Gallstones, Gallstones & Laparoscopic Cholecystectomy, Hepato-Pancreato-Biliary Cancers, Liver Cancer, Liver Transplantation, Liver Tumours, Pancreatic Cancer, Pancreatic Endocrine Tumors, Pancreatic Endocrine Tumours, Pancreatic Tumours, Primary Liver Cancer / Hepatocellular carcinoma (HCC).

Clinical Appointments

  • Consultant Hepato-pancreato-biliary and Transplant Surgery Singapore General HospitalSingapore General Hospital
  • Consultant Division of Surgery & Surgical Oncology National Cancer Centre SingaporeNational Cancer Centre Singapore

Academic Appointments

  • Duke-NUS Medical School
  • Yong Loo Lin School of Medcine, National University of Singapore
  • Adjunct Instructor SingHealth Duke-NUS Surgery Academic Clinical Programme


Dr Tan is a Consultant Surgeon with the Department of Hepatopancreatobiliary and Transplant Surgery.

He graduated from the National University of Singapore in 2008 and completed his General Surgery training at the Singapore General Hospital. During his training, he was awarded the National Medical Research Council Overseas Research Training Fellowship to study the effects of ischemia-reperfusion injury on hepatic oval cells with Dr Ari Cohen at the Ochsner Clinic, USA. He is a Fellow of the Royal College of Surgeons (Edinburgh), and holds a Master of Medicine (Surgery) from the National University of Singapore, and a Master of Public Health from the Bloomberg School of Public Health, Johns Hopkins University. Upon completing his specialist training he underwent further subspecialty training with an American Society of Transplant Surgeons (ASTS) accredited 2-year fellowship program in abdominal organ transplantation at the Mayo Clinic (Rochester), USA.

Dr Tan’s clinical practice is focused on abdominal organ transplantation and conditions involving the liver, pancreas, and biliary tract. He adopts a collaborative multi-disciplinary approach to deliver individualized care to each patient. His clinical efforts are directed primarily at improving outcomes after organ transplantation, and in the treatment of advanced cancer.

He is committed to an academic surgical practice, with active interests in tumour biology, immunology, and novel therapeutics in the treatment of cancer. He also has research interests in health policy and data analytics, which he believes can guide decision-making for clinicians to improve healthcare standards. He is engaged in medical education and the training of budding surgeons through the use of technology and adaptive learning methods.


  • Abdominal Transplant Surgery Fellowship (Mayo Clinic, Rochester)
  • Master in Public Health (Bloomberg School of Public Health, Johns Hopkins University)
  • Certificate in Health Finance and Management (Bloomberg School of Public Health, Johns Hopkins University)
  • Fellowship Diploma of the Royal College of Surgeons (Edinburgh)
  • Master in Medicine (Yong Loo Lin School of Medicine, National University of Singapore)
  • Membership Diploma of the Royal College of Surgeons (Edinburgh)
  • Bachelor of Medicine and Bachelor of Surgery (Yong Loo Lin School of Medicine, National University of Singapore)

Professional Appointments and Committee Memberships

  • Member, American Society of Transplant Surgeons
  • Member, Mayo Clinic Alumni Association
  • Member,  International Hepato-Pancreato-Biliary Association
  • Fellow, Royal College of Surgeons (Edinburgh)
  • Life Member, Hepatopancreatobiliary Association (Singapore)


  • Young Investigator Award, Asia-Pacific Hepato-Pancreato-Biliary Association
  • Course Sponsorship Award, SingHealth Surgery Academic Clinical Program
  • Overseas Research Training Fellowship, National Medical Research Council Singapore
  • Best Clinical Tutor AY12/13, Yong Loo Lin School of Medicine, National University of Singapore
  • Best Medical Officer Award, National University Hospital
  • Best House Officer Award, Singapore Health Services
  • Excellence Award (Community Service), National University of Singapore Medical Society    

Research Interests


  • EK Tan, BK Tan, HC Fong, D Chua, KY Chew, YX Koh, AYF Chung, SY Lee, JY Teo, PC Cheow, CY Chan, BKP Goh, PR Jeyaraj. Impact of microsurgical anastomosis of hepatic artery on arterial complications and survival outcomes after liver transplantation. Trans Proceedings 2021;53(1): 65-72 PMID:32951861
  • EK Tan, YX Koh, T Kee, JB Juhari, TE Tan, DKL Sim, AYL Ho, L Krishnan, PS Tee, TL Krishnamoorthy, BKP Goh, BH Tan, SJ Chung, GC Phua, PR Jeyaraj. Waitlisted transplant candidates’ attitudes and concerns toward transplantation during COVID-19. Ann Transplant 2020 PMID:33289727
  • Chan KS, Srinivasan N, Koh YX, Tan EK, Teo JY, Lee SY, Cheow PC, Jeyaraj PR, Chow PKH, Ooi LLPJ, Chan CY, Chung AYF, Goh BKP. Comparison between long and short-term venous patencies after pancreatoduodenectomy or total pancreatectomy with portal/superior mesenteric vein resection stratified by reconstruction type. PLoS One 2020;15(11):e0240737 PMID:33151977
  • JY Teo, AFW Ho, H Bulluck F Gao, J Chong, YK Koh, EK Tan, JB Abdul Latiff, SH Chua, BKPH Goh, CY Chan, AYF Chung SY Lee, PC Cheow, LLPK Ooi, BR Davidson, PR Jeyaraj, DJ Hausenloy. HPB (Oxford) 2020;22(9):1250-1257 PMID:32007393
  • EK Tan, T Taner, JK Heimbach, GJ Gores, CB Rosen. Liver Transplantation for peri-hilar cholangiocarcinoma. J Gastrointest Surg 2020;24(11):2679-2685 PMID:32671802
  • BKP Goh, RHS Park, YX Koh, JY Teo, EK Tan, PC Cheow, CH Thng, AS Low, DM Tan, PKH Chow, CY Chan, AYF Chung, LLPJ Ooi. Changing trends in the clinicopathological features, practices and outcomes in the surgical management for cystic lesions of the pancreas and impact of the international guidelines: Single institution experience with 462 cases between 1995-2018. Pancreatology 2020;20(8):1786-1790 PMID:33008749
  • JS Chung, EK Tan, T Kee, TL Krishnamoorthy, GC Phua, DW Sewa, BH Ong, TE Tan, C Sivathasan, VHL Gan, BKP Goh, PR Jeyaraj, BH Tan. Practical considerations for solid organ transplantation during the COVID-19 global outbreak: the experience from Singapore. Transplant Direct 2020;8(6):e554 PMID:32607420
  • EK Tan, CB Rosen, JK Heimbach, GJ Gores, D Zamora-Valdes, T Taner. Living donor liver transplantation for perihilar cholangiocarcinoma – outcomes and complications. J Am Coll Surg 2020;231(1):98-110 PMID:32035181
  • HL Tan, EK Tan, JY Teo, JH Jam, SY Lee, PC Cheow, PR Jeyaraj, PK Chow, AY Chung, LL Ooi, CY Chan, BKP Goh. Outcome of minimally-invasive versus open pancreatectomies for solid pseudopapillary neoplasms of the pancreas: a 2:1 matched case-control study. Ann Hepatobiliary Pancreat Surg 2019;23(3):252-257 PMID:31501814
  • YX Guo, EK Tan, NL Syn, TL Krishnamoorthy, CK Tan, R Lim, SY Lee, CY Chan, PC Cheow, AYF Chung, PR Jeyaraj, BKP Goh. Repeat liver resection versus salvage liver transplantation for recurrent hepatocellular carcinoma: a propensity score-adjusted and –matched comparison analysis. Ann Hepatobiliary Pancreat Surg 2019;23(4):305-312 PMID:31824994
  • EK Tan, AJ Bentall, PG Dean, MF Shaheen, MD Stegall, CA Schinstock. Use of eculizumab for active antibody-mediated rejection that occurs early post-kidney transplantation: A consecutive series of 15 cases. Transplantation 2019;103(11):2397-2404 PMID:30801549
  • YX Guo, EK Tan, TL Krishnamoorthy, CK Tan, BH Tan, TT Tan, SY Lee, CY Chan, PC Cheow, AYF Chung, PR Jeyaraj, BKP Goh. Outcomes of salvage liver transplant for recurrent hepatocellular carcinoma: A comparison with primary liver transplant. Ann Hepatobiliary Pancreat Surg 2019;23(1):1-7 PMID:30863801
  • SY Lee, BKP Goh, G Sepideh, JC Allen, RP Merkow, JY Teo, D Chandra, YX Koh, EK Tan, JH Kam, PC Cheow, PKH Chow, LLPJ Ooi, AYF Chung, MI D’Angelica, WR Jarnagin, TP Kingham, CY Chan. Laparoscopic liver resection difficulty score – a validation study. J Gastrointest Surg 2019;23:545 PMID:30421119
  • EK Tan, BKP Goh, SY Lee, TL Krishnamoorthy, CK Tan, PR Jeyaraj. Liver transplant waitlist outcomes and the allocation of HCC MELD exception points at a low-volume center. Transplant Proc 2018;50(10):3564-70 PMID:30577239
  • D Chua, A Low, YX Koh, PC Cheow, JH Kam, JY Teo, EK Tan, A Chung, LL Ooi, CY Chan, SY Lee. A retrospective review of correlative radiological assessment and surgical exploration for hilar cholangiocarcinoma. Ann Hepatobiliary Pancreat Surg 2018;22(3):216-22 PMID:30215043
  • Chin KM, Allen JC, Teo JY, Kam JH, Tan EK, Koh YX, Goh KPB, Cheow PC, Raj P, Chow KHP, Chung YFA, Ooi LL, Chan CY, Lee SY. Predictors of post-hepatectomy liver failure in patients undergoing extensive liver resections for hepatocellular carcinoma. Ann Hepatobiliary Pancreat Surg 2018;22(3):185-96 PMID:30215040
  • Ye QJ, Desai SR, EK Tan. A case of melioidosis presenting as acalculous cholecystitis. Cureus 2018;22(10):e2864 PMID:30148016
  • EK Tan, M Shuh, H Francois-Vaughan, J Sanders, AJ Cohen. Negligible oval cell proliferation following ischemia/reperfusion injury with and without partial hepatectomy. Ochsner J 2017;17(1):31-37 PMID:28331445
  • EK Tan, M Shuh, AJ Cohen. Liver injury models for induction of hepatic oval cells in rodents. J Liver Res Disord Ther 2015;1(1):00005 DOI:10.15406/jlrdt.2015.01.00005
  • VG Shelat, EK Tan, LT Teo, V Appasamy, MT Chiu. Outcomes of Nonoperative Management of Blunt Splenic Injury – Asian Experience. Int Surg 2015;100(9-10):1281-6 DOI:10.9738/INTSURG-D-14-00160.1
  • EK Tan, SG Tan. The Permanent Catheter. Hemodial Int 2014;18(2):522-4 PMID:24164973
  • EK Tan, VTW Lee, SKY Chang, IS Ganpathi, K Madhavan. Laparo-endoscopic single-site minor hepatectomy for liver tumors. Surgical Endoscopy 2012; 26(7): 2086-91 PMID:22234591
  • EK Tan, VG Shelat, LT Teo, MT Chiu. Peritoneo-cutaneous fistula secondary to skin excoriation from a large chronic incisional hernia. Ann Acad Med Singapore 2010;39:872-3 PMID:21165530
  • EK Tan, PJLL Ooi. Colorectal cancer liver metastases – understanding the differences in the management of synchronous and metachronous disease. Ann Acad Med Singapore 2010; 39: 719-33 PMID:20957308
  • EK Tan, WL Chung, YJ Lew, A Tan, MY Chan, BC Tai, WP Koh. Characteristics, control and complications of hypertensive patients in primary care – a community-based study in Singapore. Ann Acad Med Singapore 2009;38:5806 PMID:19890575

Research Trials