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Dr Tan Chuen Wen

Dr Tan Chuen Wen

MBBCh BAO, MRCP(UK), MMed(Int Med), FRCPath (UK)

Senior Consultant

Singapore General Hospital

Specialty: Haematology

Sub-specialties: Vascular Anomalies, Thrombosis and Haemostasis, Laboratory Haematology

Conditions Treated by this Doctor:
Acute Lymphocytic Leukemia (ALL), Aplastic Anaemia, Chronic lymphocytic leukemia, Chronic Myeloid Leukemia (CML), Deep Vein Thrombosis, Deep Vein Thrombosis, essential thrombocythemia, Haemophilia and other bleeding disorders, Multiple Myeloma, Myelodysplastic Syndromes, Myelofibrosis, Polycythemia Vera, Pulmonary Embolism, Thalassaemia.

Clinical Appointments

  • Senior Consultant SingHealth Duke-NUS Blood Cancer Centre
  • Senior Consultant SingHealth Duke-NUS Vascular Centre
  • Senior Consultant Haematology Singapore General HospitalSingapore General Hospital
  • Visiting Consultant Department of Pathology Sengkang General HospitalSengkang General Hospital

Profile

Dr Tan Chuen Wen is a consultant with the Department of Haematology, Singapore General Hospital. Dr Tan graduated from The National University of Ireland in 2007. He completed his internal medicine and haematology training in Singapore. His subspeciality interest is in the area of thrombosis and haemostasis, in particular platelet disorders. He was awarded the Health Manpower Development Program (HMDP) award to further his research in platelet disorders at the ANZAC Research Institute, University of Sydney. He was awarded the Nurturing Clinician Scientist Scheme – CIV Award in recognition of his developing research field.  Dr Tan is also a committed educator and serves core faculty for the haematology senior residency programme. 

Education

  • ​MB BCh BAO, National University of Ireland, 2007
  • MRCP (UK), 2011
  • M. Med (internal Medicine), National University of Singapore, 2011
  • FRCPath (Haematology) (UK), 2015

Professional Appointments and Committee Memberships

  • Deputy Director, Laboratory Haematology Services, Department of Haematology
  • Clinical Assistant Professor – Duke NUS School of Medicine
  • Core Faculty – Haematology Senior Residency Programme
  • President-elect – Singapore Society of Haematology

Awards

  • Nurturing Clinician Scientist Scheme – CIV Award
  • Singapore General Hospital COVID Research Grant
  • Best Registrar Award 2015
  • Singapore General Hospital Service with a Heart Award 2014

Research Interests

  • ​Thrombosis and haemostasis
  • Quantitative and qualitative platelet disorders
  • Anticoagulation
  • Antiplatelet

Publications

  • Lee LH, Nagarajan C, Tan CW, Ng HJ. Epidemiology of Cancer-Associated Thrombosis in Asia: A Systematic Review. Front Cardiovasc Med. 2021;8(May). 
  • Tan CW, Fan BE, Teo WZY, Tung ML, Shafi H, Christopher D, et al. Low incidence of venous thrombosis but high incidence of arterial thrombotic complications among critically ill COVID-19 patients in Singapore. Thromb J. 2021 Mar;19(1):14. 
  • Pravin RR, Huang BX, Sultana R, Tan CW, Goh KJ, Chan M-Y, et al. Mortality Trends of Oncology and Hematopoietic Stem Cell Transplant patients supported on Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-Analysis. J Intensive Care Med. 2021 Aug;8850666211021561. 
  • Tan JY, Tan CW, Wong WH, Cheong MA, Lee LH, Kalimuddin S, et al. Post-hospitalization venous thromboembolism in COVID-19 patients: Evidence against routine post-hospitalization prophylactic anticoagulation. Int J Lab Hematol [Internet]. 2021 Jun 19
  • Ong SY, Tan CW, Ramya V, Malik AA, Lee XH, Hwang JCC, et al. Risk factors and predictors of treatment responses and complications in immune thrombocytopenia. Ann Hematol [Internet]. 2021 Mar;100(3):645–51. 
  • Tan CW, Tan JY, Wong WH, Cheong MA, Ng IM, Conceicao EP, et al. Clinical and laboratory features of hypercoagulability in COVID-19 and other respiratory viral infections amongst predominantly younger adults with few comorbidities. Sci Rep [Internet]. 2021;11(1):1793. 
  • Tohidi-Esfahani I, Tan S, Tan CW, Johnson L, Marks DC, Chen VM. Platelet procoagulant potential is reduced in platelet concentrates ex vivo but appears restored following transfusion. Transfusion. 2021 Oct; 
  • Tan CW, Low JGH, Wong WH, Chua YY, Goh SL, Ng HJ. Critically ill COVID-19 infected patients exhibit increased clot waveform analysis parameters consistent with hypercoagulability. Am J Hematol. 2020;95(7):E156–8. 
  • Tan CW, Ho LP, Kalimuddin S, Cherng BPZ, Teh YE, Thien SY, et al. Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B(12) in combination on progression to severe outcomes in older patients with coronavirus (COVID-19). Nutrition. 2020;79–80:111017. 
  • Tan CW, Wong WH, Cheen MHH, Chu YMH, Lim SS, Ng LCK, et al. Assessment of aPTT-based clot waveform analysis for the detection of haemostatic changes in different types of infections. Sci Rep. 2020 Aug;10(1):14186. 
  • Tan CW, Wong WH, Idros R, Chan YH, Kaur H, Tng ARK, et al. Role of platelets in thrombin generation amongst patients with non-transfusion-dependent thalassaemia. Ann Hematol. 2019 Apr;98(4):861–8. 
  • Tay HM, Lai YF, Kong MC, See E, Yeang SH, Koh SK, et al. Generational performance of three point-of-care testing devices compared with standard laboratory measurement of the international normalised ratio across extended ranges. J Clin Pathol. 2019 Apr;72(4):311–5. 
  • Tan CW, Cheen MHH, Wong WH, Wu IQ, Chua BLW, Ahamedulla SH, et al. Elevated activated partial thromboplastin time-based clot waveform analysis markers have strong positive association with acute venous thromboembolism. Biochem medica. 2019 Jun;29(2):20710. 
  • Ang AL, Wong WH, Tan J, Ng HJ, Tan CW, Kuperan P, et al. Ex vivo haemostatic capacity of plasma upon thawing and beyond: a comparison between fresh frozen plasma (FFP) and frozen plasma prepared from whole blood stored at room temperature up to 24 hours postcollection (RTFP24). Vox Sang. 2019 Apr;114(3):198–206. 
  • Tan CW, Bourcy M, Pasalic L, Chen VM. Flow Cytometry Assessment of Procoagulant Platelets Using a Dithiol-Reactive Probe. Methods Mol Biol. 2019;1967:305–21. 
  • Reddel CJ, Tan CW, Chen VM. Thrombin Generation and Cancer: Contributors and Consequences. Cancers (Basel). 2019 Jan;11(1). 
  • Tan CW, Wong WH, Tan CK, Chan YH, Kaur H, Lee LH, et al. The Influence of Race on Plasma Thrombin Generation In Healthy Subjects in Singapore. Clin Appl Thromb  Off J Int  Acad Clin Appl Thromb. 2018 Oct;24(7):1144–7. 
  • Kaur H, Yeang SH, See E, Grant D, Tan CW, Wong WH, et al. Reversal of rivaroxaban using Prothromplex Total, a 4-factor prothrombin complex. Vol. 156, Thrombosis research. United States; 2017. p. 117–8. 
  • Fung FY, Wong WH, Ang SK, Koh HL, Kun MC, Lee LH, et al. A randomized, double-blind, placebo- controlled study on the anti-haemostatic effects of Curcuma longa, Angelica sinensis and Panax ginseng. Phytomedicine. 2017 Aug;32:88–96. 
  • Ong SY, Chin YA, Than H, Tan CW, Yap ES, Wong WH, et al. Rivaroxaban for heparin-induced thrombocytopenia: adding to the evidence. Vol. 96, Annals of hematology. Germany; 2017. p. 525–7. 
  • Wong WH, Yip CY, Sum CL, Tan CW, Lee LH, Yap ES, et al. A Practical Guide to Ordering and Interpreting Coagulation Tests for Patients on Direct Oral Anticoagulants in Singapore. Ann Acad Med Singapore. 2016 Mar;45(3):98–105. 
  • Yeang SH, Chan A, Tan CW, Lim ST, Ng HJ. Incidence and Management of Toxicity Associated with LAsparaginase in the Treatment of ALL and NK/TCell Lymphoma: an Observational Study. Asian Pac J Cancer Prev. 2016;17(7):3155–60. 
  • Tan CW, Tan-Koi W-C, Ng J, Chan CM, Hwang WYK. A cluster of Epoetin-associated pure red cell aplasia: clinical features and the possible association of HLA-DRB1*12:02. Pharmacogenomics. 2016 Jul;17(11):1235–43. 
  • Tan CW, See SJ, Tham CK, Ang AL. Treatment-related Acute Myeloid Leukaemia After Temozolomide for Glioblastoma Multiforme. Vol. 43, Annals of the Academy of Medicine, Singapore. Singapore; 2014. p. 334–7. 
  • Tan CW, Hae Tha M, Joo Ng H. Creatine supplementation and venous thrombotic events. Vol. 127, The American journal of medicine. United States; 2014. p. e7-8. 

Research Trials