Profile
Dr Isaac Seow-En graduated from the National University of Singapore and has been a specialist with SGH Department of Colorectal Surgery since 2017. He completed a year-long fellowship training in advanced minimally invasive colorectal surgery in Taiwan, Republic of China, under the mentorship of Professor William Tzu-Liang Chen, an internationally renowned colorectal surgeon. He has published widely in the field of colorectal surgery, with more than 50 peer-reviewed publications and 6 book chapters, particularly in the area of innovative surgical technique. Dr Seow-En has an interest in laparoscopy, transanal minimally invasive surgery (TAMIS) for rectal cancer, natural orifice specimen extraction (NOSE), as well as surgical training.
Education
- Fellow of the Royal College of Surgeons, Edinburgh (2017)
- Master of Medicine, Surgery (2016)
- Member of the Royal College of Surgeons, Edinburgh (2013)
- Bachelor of Medicine, Bachelor of Surgery, National University of Singapore (2009)
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Professional Appointments and Committee Memberships
- Member, Society of Colorectal Surgeons (Singapore)
- Fellow, The Royal College of Surgeons (Edinburgh)
- Organising and Scientific Chairman, Inaugural SingHealth Colorectal Congress
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Awards
- Service with a Heart Award (2022)
- Best Video, Singapore Colorectal Week (2021)
- SGH 10 Years Long Service Award (2020)
- Wong Hock Boon Society Outstanding Mentor Award (2019)
- NUS Dean’s Award for Teaching Excellence (2019)
- SingHealth Human Manpower Development Plan Award (2019)
- Service with a Heart Award (2018)
- NUS Junior Doctor Teaching Award (2016)
- Outstanding Resident Award (2015)
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Publications
- Seow-En I, Seow-Choen F. Warm water irrigation is useful for the identification of a bleeding colonic diverticulum [published online ahead of print, 2023 May 17]. Clin Endosc. 2023;10.5946/ce.2022.279. doi:10.5946/ce.2022.279
- Seow-En I, Khor SN, Koo CH, Wee IJY, Tan EK. Transvaginal Natural Orifice Specimen Extraction (NOSE) in Laparoscopic Colorectal Cancer Surgery With New Insights on Technique and Patient Selection [published online ahead of print, 2023 Jul 24]. Surg Laparosc Endosc Percutan Tech. 2023;10.1097/SLE.0000000000001208. doi:10.1097/SLE.0000000000001208
- Seow-En I, Li KK, Khor SN, Tan EK. Laparoscopic sigmoid colectomy with transanal natural orifice specimen extraction for sigmoid volvulus - A video vignette [published online ahead of print, 2023 Jul 19]. Colorectal Dis. 2023;10.1111/codi.16671. doi:10.1111/codi.16671
- Isaac Seow-En, Kelvin Kaiwen Li, Shao Nan Khor, and Emile Kwong-Wei Tan. Three-Port Laparoscopic Splenic Flexure Colectomy for Descending Colon Cancer with Intracorporeal Colocolic Anastomosis and Transvaginal Natural Orifice Specimen Extraction. Videoscopy.Jul 2023.https://imsva91-ctp.trendmicro.com:443/wis/clicktime/v1/query?url=http%3a%2f%2fdoi.org%2f10.1089%2fvor.2023.0004&umid=26CFCCF5-0330-9606-BC13-4BDBDAF60D93&auth=6e3fe59570831a389716849e93b5d483c90c3fe4-9e4237e9a7272f79dfbe092afe354b5af2e49fe7
- Koo CH, Chok AY, Wee IJY, Seow-En I, Zhao Y, Tan EJKW. Effect of preoperative oral antibiotics and mechanical bowel preparation on the prevention of surgical site infection in elective colorectal surgery, and does oral antibiotic regime matter? a bayesian network meta-analysis. Int J Colorectal Dis. 2023;38(1):151. Published 2023 May 31. doi:10.1007/s00384-023-04444-3
- Zheng V, Wee IJY, Abdullah HR, Tan S, Tan EKW, Seow-En I. Same-day discharge (SDD) vs standard enhanced recovery after surgery (ERAS) protocols for major colorectal surgery: a systematic review. Int J Colorectal Dis. 2023;38(1):110. Published 2023 May 1. doi:10.1007/s00384-023-04408-7
- Chen HLR, Seow-En I, Chok AY, Ngo NT, Cheng TL, Tan KE. The role of magnetic resonance tumour regression grade in the prediction of regression and survival of rectal adenocarcinoma after long-course chemoradiotherapy: a cohort study. Ann Med Surg (Lond). 2023;85(4):842-848. Published 2023 Apr 3. doi:10.1097/MS9.0000000000000441
- Lam KK, Low YS, Lo M, et al. KRAS-specific antibody binds to KRAS protein inside colorectal adenocarcinoma cells and inhibits its localization to the plasma membrane. Front Oncol. 2023;13:1036871. Published 2023 Mar 27. doi:10.3389/fonc.2023.1036871
- Wee IJY, Koo CH, Seow-En I, Ng YYR, Lin W, Tan EJK. Laser hemorrhoidoplasty versus conventional hemorrhoidectomy for grade II/III hemorrhoids: a systematic review and meta-analysis. Ann Coloproctol. 2023;39(1):3-10. doi:10.3393/ac.2022.00598.0085
- Seow-En I, Lin W, Chen LR, Tan EK. Three-port laparoscopic anterior resection for sigmoid cancer with transanal natural orifice specimen extraction (NOSE) and single-stapling colorectal anastomosis. Tech Coloproctol. 2023;27(8):695-696. doi:10.1007/s10151-022-02736-4
- Seow-En I, Tan EK. Modified suction connecting tubing: a simple and cost-effective method of smoke evacuation during transanal total mesorectal excision - A video vignette. Colorectal Dis. 2023;25(5):1054-1055. doi:10.1111/codi.16437
- Seow-En I, Koh YX, Tan EK. Transanal Natural Orifice Specimen Extraction Following Combined Laparoscopic Anterior Resection and Liver Resection. Dis Colon Rectum. 2023;66(5):e216-e217. doi:10.1097/DCR.0000000000002610
- Seow-En I, Koh YX, Tan EK. Transvaginal Natural Orifice Specimen Extraction Following Laparoscopic Combined D3 Right Hemicolectomy and Liver Resection. Dis Colon Rectum. 2022;65(12):e1070-e1071. doi:10.1097/DCR.0000000000002440
- Seow-En I, Chen LR, Li YX, et al. Outcomes after natural orifice extraction vs conventional specimen extraction surgery for colorectal cancer: A propensity score-matched analysis. World J Clin Oncol. 2022;13(10):789-801. doi:10.5306/wjco.v13.i10.789
- Ng WKD, Chok AY, Ng YY, Seow-En I, Tan EK. Efficacy of biofeedback therapy for faecal incontinence in an Asian population [published online ahead of print, 2022 Oct 29]. ANZ J Surg. 2022;10.1111/ans.18131. doi:10.1111/ans.18131
- Seow-Choen F, Seow-En I. Pilonidal disease: A new look at an old disease. August 2022. Semin Colon Rectal Surg. DOI: 10.1016/j.scrs.2022.100909.
- Seow-En I, Ng YY, Tan IBH, Tan EK. Transanal total mesorectal excision and delayed coloanal anastomosis without stoma for low rectal cancer [published online ahead of print, 2022 Aug 27]. Tech Coloproctol. 2022;10.1007/s10151-022-02677-y.
- Joanito I, Wirapati P, Zhao N, et al. Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer. Nat Genet. 2022;54(7):963-975.
- Seow-En I, Koo CH, Chen LR, Tan EK. 3-port laparoscopic D3 right hemicolectomy with transvaginal natural orifice specimen extraction - A Video Vignette. Colorectal Dis. 2022;24(7):880-881.
- Seow-En I, Khor SN, Tan KW. Laparoscopic 3-port anterior resection with transvaginal natural orifice specimen extraction (NOSE) in a patient with a high BMI: A video vignette [published online ahead of print, 2022 Jun 4]. Colorectal Dis. 2022;10.1111/codi.16213.
- Seow-En I, Chen WT. Complete mesocolic excision with central venous ligation/D3 lymphadenectomy for colon cancer - A comprehensive review of the evidence. Surg Oncol. 2022;42:101755.
- Chua D, Loh AH, Tan E, Seow-En I. Perivascular epithelioid cell tumour (PEComa): an unusual cause of painful defaecation. BMJ Case Rep. 2022;15(2):e247686. Published 2022 Feb 9. doi:10.1136/bcr-2021-247686
- Shaw MYV, Asokkumar R, Tan Kwong Wei EJ, Seow-En I. Colonic angiodysplasia: a culprit of obscure gastrointestinal bleeding in a patient with Heyde syndrome. BMJ Case Rep. 2022;15(1):e247595. Published 2022 Jan 13. doi:10.1136/bcr-2021-247595
- Seow-En I, Tan YG, Tay KJ. Laparoscopic sphincter-preserving total pelvic exenteration with transanal total mesorectal excision for locally advanced rectal cancer - a video correspondence. Colorectal Dis. 2021 Dec 2. doi: 10.1111/codi.16011. Epub ahead of print. PMID: 34856065.
- Seow-En I, Chok AY, Tan EK. Transanal total mesorectal excision with two stage Turnbull-Cutait pull-through for delayed low anastomotic leakage - a video vignette. Colorectal Dis. 2021 Nov 18. doi: 10.1111/codi.15993. Epub ahead of print. PMID: 34796602.
- Asokkumar R, Seow I, Chin Hong L, Chang J, Tan D, Salazar E. Rostered routine testing for severe acute respiratory coronavirus virus 2 infection among healthcare workers: Do we detect more? J Gastroenterol Hepatol. 2021 Oct 25. doi: 10.1111/jgh.15720. Epub ahead of print. PMID: 34694645.
- Chang SC, Seow-En I, Ke TW, Chen HC, Chen YC, Tsai YY, Wang HM, Chen WT. Laparoscopic total pelvic peritonectomy for colorectal cancer pelvic carcinomatosis: a retrospective case series and photographic/videographic step-by-step guide. Surg Endosc. 2021 Sep 7. doi: 10.1007/s00464-021-08719-0. Epub ahead of print. PMID: 34494157.
- Seow-En I, Chok AY, Matchar DB, Yoon S, Chong DQ, Tan EK. Long-term quality of life, sexual health and gastrointestinal function following colorectal cancer resection in an Asian cohort. Colorectal Dis. 2021 Jun 7. doi: 10.1111/codi.15768.
- Seow-En I, Ke TW, Chen YC, Tzu-Liang Chen W. A combined abdominal and transanal minimally invasive (TAMIS) approach in redo anastomoses for severe refractory rectal strictures. Colorectal Dis. 2021 May;23(5):1258-1261.
- Seow-En I, Chang SC, Ke TW, Shen MY, Chen HC, William Tzu-Liang Chen. Uncomplicated Sigmoid Volvulus Is Ideal for Laparoscopic Sigmoidectomy With Transrectal Natural Orifice Specimen Extraction. Dis Colon Rectum. 2021 May;64(5):e90-e93.
- Seow-En I, Ke TW, Chang SC, Chen WT. Laparoscopic retrojejunal trans-mesenteric anastomosis for extended left-sided colorectal resections - a new solution to an old problem. Colorectal Dis. 2021 May;23(5):1262-1267.
- Seow-En I, Wu J, Yang LWY, Tan JSQ, Seah AWH, Foo FJ, Chang M, Tang CL, Tan EKW. Results of a colorectal enhanced recovery after surgery (ERAS) programme and a qualitative analysis of healthcare workers' perspectives. Asian J Surg. 2020 Aug 27:S1015-9584(20)30246-3.
- Seow-En I, Seow-Choen F. Comment on: Transanal total mesorectal excision for rectal cancer has been abandoned in Norway. Br J Surg. 2020 Jun;107(7):e223.
- Seow-En I, Tan WJ, Dorajoo SR, Soh SHL, Law YC, Park SY, Choi GS, Tan WS, Tang CL, Chew MH. Prediction of overall survival following colorectal cancer surgery in elderly patients. World J Gastrointest Surg. 2019 May 27;11(5):247-260.
- Seow-En I, Seow-Choen F. An Initial Experience Comparing Robotic Total Mesorectal Excision (RTME) and Transanal Total Mesorectal Excision (taTME) for Low Rectal Tumours. Ann Acad Med Singapore. 2018 May;47(5):188-190.
- Seow-En I, Hwarng G, Tan GHC, Ho LML, Teo MCC. Palliative surgery for Krukenberg tumors - 12-year experience and review of the literature. World J Clin Oncol. 2018 Feb 10;9(1):13-19.
- Seow-En I, Seow-Choen F, Koh PK. An experience with video-assisted anal fistula treatment (VAAFT) with new insights into the treatment of anal fistulae. Tech Coloproctol. 2016 Apr 8.
- Seow-En I, Seow-Choen F. A prospective randomised trial on the use of Coca-Cola Zero® versus water for polyethylene glycol bowel preparation before colonoscopy. Colorectal Dis. 2015 Dec 18.
- Seow-En I, Loh AH, Lian DW, Nah SA. Thyroglossal duct cyst carcinoma: diagnostic and management considerations in a 15-year-old with a large submental mass. BMJ Case Rep. 2015 Jul 6;2015.
- Seow-En I, Seow-Choen F. Intestinal type gastric adenocarcinoma with unusual synchronous metastases to the colorectum and bladder. World J Clin Cases. 2015 Jun 16;3(6):533-7.
- Seow-En I, Seow-Choen F. Anorectal reconstruction using graciloplasty after abdominoperineal resection – a review of the current literature and recommendations for the future. Acta chirurgica iugoslavica 2014 Volume 61, Issue 2, Pages: 39-45
- Seow-En I, Ngu J. Routine operative swab cultures and post-operative antibiotic use for uncomplicated perianal abscesses are unnecessary. ANZ J Surg. 2014 Nov 21.
- Seow-En I, Seow-Choen F, Lim TK, Leow WQ. Primary omental gastrointestinal stromal tumour (GIST) presenting with a large abdominal mass and spontaneous haemoperitoneum.
- BMJ Case Rep. 2014 Nov 3;2014.
- Seow-En I, Seow-Choen F. Sigmoid volvulus treated by mini-incision. Tech Coloproctol. 2014 Dec;18(12):1169-71.
- Seow-En I, Foo FJ, Tang CL. Jejunojejunal intussusception secondary to submucosal lipoma resulting in a 5-year history of intermittent abdominal pain. BMJ Case Rep. 2014 Oct 29;2014.
- Seow-En I, Chiow AK, Tan SS, Poh WT. Eosinophilic cholangiopathy: the diagnostic dilemma of a recurrent biliary stricture. Should surgery be offered for all? BMJ Case Rep. 2014 Jan 3;2014.
- Seow-Choen F, Seow-En I. Martius flap for ano-vaginal fistula: a photographic step by step guide. Tech Coloproctol. 2013 Aug;17(4):467-8.
- Seow-En I, Daud MA, Seow-Choen F. The umbilicus as a site for defunctioning ileostomies. Tech Coloproctol. 2011 Jun;15(2):213-4.
- Seow-En I, Tan KY, Mohd Daud MA, Seow-Choen F. Traditional laparoscopic colorectal resections can be performed effectively using a three-port technique. Tech Coloproctol. 2011 Mar;15(1):91-3.
- Seow-En I, Seow-Choen F, Tseng PT. Prior uterine perforation resulting in intestinal obstruction in a subsequent pregnancy. Tech Coloproctol. 2010 Dec;14(4):369.
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