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Dr Leow Wei Qiang from SGH

Adj Asst Prof Leow Wei Qiang

MBBS, FRCPA, FAMS

Consultant

Specialty: Anatomical Pathology

Sub-specialties: Gastrointestinal and Hepatopancreatobiliary Pathology

Clinical Appointments

  • Consultant Pathology Singapore General HospitalSingapore General Hospital

Academic Appointments

  • Pathology Residency Programme SingHealth Duke-NUS Pathology Academic Clinical Programme

Profile

​Dr Leow Wei Qiang is currently a consultant pathologist at the Department of Anatomical Pathology, Division of Pathology, Singapore General Hospital. He graduated from the Faculty of Medicine, National University of Singapore in 2006 and did his postgraduate training in Histopathology with the then Histopathology and Cytology Sections, Department of Pathology, Singapore General Hospital. He was awarded the fellowships from the Royal College of Pathologists of Australasia and Academy of Medicine Singapore in 2015. His interests are in gastrointestinal and hepatopancreatobiliary pathology.

In 2016, he was awarded the SingHealth Health Manpower Development Plan to pursue advanced diagnostic training and research in hepatopancreatobiliary pathology and liver cancers at the Mount Sinai Liver Cancer Program at the Tisch Cancer Institute, under the tutelage of Professors Swan N. Thung and Josep M. Llovet respectively. He has research interests in hepatocellular carcinoma, cholangiocarcinoma, non-alcoholic steatohepatitis, autoimmune hepatitis, inflammatory bowel disease, colorectal carcinoma and gastrointestinal stromal tumours. He is also enthusiastic about teaching at the graduate and postgraduate levels, holding appointments of programme director to the SingHealth Pathology Residency Programme as well as adjunct instructorships to Duke-NUS Medical School and Nanyang Technological University.

Education

  • ​Fellow of Royal College of Pathologists Australasia (FRCPA) 2015
  • Fellow of Academy of Medicine Singapore (FAMS) 2015
  • Bachelor of Medicine and Bachelor of Surgery (MBBS) 2006

Professional Appointments and Committee Memberships

  • Faculty, Pathologist’s Assistant Program, Singapore General Hospital
  • Adjunct Assistant Professor, Duke-NUS Medical School
  • Adjunct Instructor, Nanyang Technological University
  • Member, American Association for the Study of Liver Diseases (AASLD)
  • Member, United States and Canadian Academy of Pathology (USCAP)
  • International Corresponding Member, Hans Popper Hepatopathology Society (HPHS)
  • Member, Singapore Division of International Academy of Pathology (IAP)
  • Fellow, Academic Medicine Education Institute (AM.EI), Duke-NUS Medical School
  • Member, Singapore Society of Pathology (SSP)
  • Member, Singapore Medical Association (SMA)

Awards

  • NS Excellence Award 2019
  • SAF Good Service Medal 2018
  • Khoo Pilot Award (Collaborative) 2018
  • Singhealth 10 Years Long Service Award 2017
  • Inspiring Mentor Award, Pathology Academic Clinical Program Research Day 2016
  • Health Manpower Development Plan (HMDP) Award 2016
  • Publication Prize, Pathology Academic Clinical Program Research Day 2015
  • Best Registrar Award 2013
  • Best Medical Officer Award 2012
  • RSAF Chief of Air Force Cardinal Award (Special) 2008
  • Best House Officer Award 2007

Research Interests

Publications and Research Trials

Publications

  1. Lam JH, Ng HH, Sim XN, Malavasi F, Li H, Loh JJ, Sabai K, Kim JK, Ong CC, Loh T, Leow WQ. Expression of CD38 on macrophages predicts improved prognosis in hepatocellular carcinoma. Frontiers in Immunology. 2019;10:2093.
  2. Tang CQ, Teo TZ, Heng GK, Leow WQ, Mantoo SK. Multifocal small-bowel adenocarcinoma mimicking Crohn’s disease. Gastrointestinal endoscopy. 2019 May 15.
  3. Goh GB, Leow WQ, Liang S, Wan WK, Lim TK, Tan CK, Chang PE. Quantification of hepatic steatosis in chronic liver disease using novel automated method of second harmonic generation and two-photon excited fluorescence. Scientific reports. 2019 Feb 27;9(1):2975.
  4. Chan, S. and Leow, W. Q. (2018), Sudden Collapse due to Medullary and Cervical Cord Infarction - An Unusual Presentation of Hepatocellular Carcinoma. J Forensic Sci. doi:10.1111/1556-4029.13929.
  5. Chang PE, Goh GBB, Leow WQ, Shen L, Lim KH, Tan CK. Second harmonic generation microscopy provides accurate automated staging of liver fibrosis in patients with non-alcoholic fatty liver disease. PLoS ONE 13(6): e0199166, 2018.
  6. Ruoyu Shi, Min Hoe Chew, Wei Qiang Leow. Diagnostic conundrum of a perineal tumour: a rectal gastrointestinal stromal tumour mimic. Malaysian Journal of Pathology. 2017 Dec 1;39(3).
  7. Phua LC, Goh S, Tai DW, Leow WQ, Alkaff SM, Chan CY, Kam JH, Lim TK, Chan EC. Metabolomic prediction of treatment outcome in pancreatic ductal adenocarcinoma patients receiving gemcitabine. Cancer chemotherapy and pharmacology. 2017 Dec 1:1-3.
  8. Yu Jun Wong, Ban Hock Tan, Wei Qiang Leow, Steven Joseph Mesenas. Cytomegalovirus infection masquerading as gastric carcinoma in an immune-compromised host. Proceedings of Singapore Healthcare, https://doi.org/10.1177/2010105817731797.
  9. Torrecilla S, Sia D, Harrington AN, Zhang Z, Cabellos L, Cornella H, Moeini A, Camprecios G, Leow WQ, Fiel MI, Hao K. Trunk events present minimal intra-and inter-tumoral heterogeneity in hepatocellular carcinoma. Journal of Hepatology. 2017 Aug 24.
  10. Zhao Z, Leow WQ. Concurrent Hepatic Tuberculosis and Hepatic Graft-versus-host Disease in an Allogeneic Hematopoietic Stem Cell Transplant Recipient: A Case Report. Transplantation Proceedings 2017 Sep 1 (Vol. 49, No. 7, pp. 1659-1662).
  11. HK Tan, WQ Leow, PE Chang. Ruxolitinib for the Treatment of Portal Hypertension in a Patient With Primary Myelofibrosis. Gastroenterology. May 2017; DOI: 10.1053/j.gastro.2016.08.059.
  12. JXY Sim, IH Binte Mohamed Hussain, WQ Leow. Metastatic disease masquerading as small intestinal tumoural masses: two case reports and literature review. Proceedings of Singapore Healthcare, 2010105817691996.
  13. Sarah Ng, Clarinda Chua, Matthew Ng, Anna Gan, Polly Poon, Melissa Teo, Cherylin Fu, Wei Qiang Leow, Tony Kiat Hon Lim, Alexander Chung, Si-Lin Koo, Choo Supin, Danliang Ho, Steven Rozen, Patrick Tan, Mark Wong, William Burkholder, and Iain Tan. Individualised multiplexed circulating tumour DNA assays for monitoring of tumour presence in patients after colorectal cancer surgery. Sci. Rep. 7, 40737; doi: 10.1038/srep40737 (2017).
  14. Suzuki, Y., Ng, S. B., Chua, C., Leow, W. Q., Chng, J., Liu, S. Y., Ramnarayanan, K., Gan, A., Ho, D. L., Ten, R., Su, Y., Lezhava, A., Lai, J. H., Koh, D., Lim, K. H., Tan, P., Rozen, S. G. and Tan, I. B. (2016), Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer. Mol Oncol. doi:10.1002/1878-0261.12012.
  15. Doreen Siew Ching Koay, Wei Qiang Leow, Thuan Tong Tan, Gabrielle Slapak. Recurrent hepatobiliary sepsis in a patient with von Meyenburg complexes: a case report and review of the literature. Singapore General Hospital Proceedings, September 2016, DOI: 10.1177/2010105816670413.
  16. Cheo Fan Foon, Leow Wei Qiang. Diagnosing a rare case of desmoplastic small round cell tumour on liver biopsy. Malaysian J Pathol 2016; 38(2) : 149-152.
  17. Wei Qiang Leow, Sathiyamoorthy Selvarajan. Uterine Perivascular Epithelioid Cell Tumour and Assessment of its Malignant Potential. Singapore Med J 2015; 56(9): 531 doi: 10.11622/smedj.2015143.
  18. Leow Wei Qiang, Loh Hwai Liang Alwin, Lee Lui Shiong, Goh Chin Hong Ronald. A rare case of combined placental site trophoblastic tumour with mature cystic teratoma and mixed germ cell tumour in the testis. Malaysian J Pathol 2015; 37(2) : 145-147.
  19. Wei Qiang Leow, Ivy SNG. Sinonasal haemangiopericytoma: histomorphology and differential diagnoses. Malaysian J Pathol 2015; 37(1) : 53-56.
  20. Webber Pak Wo Chan, Wei Qiang Leow. Ulcerative Colitis Diagnosed in a Patient after Primary Rectal Marginal Zone B-cell Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT) Treated. Proceedings of Singapore Healthcare. 2015, Vol 24, Number 2, pp. 123-129.
  21. Seow-En I, Seow-Choen F, Lim TK, Leow WQ. Primary omental gastrointestinal stromal tumour (GIST) presenting with a large abdominal mass and spontaneous haemoperitoneum. BMJ Case Rep. 2014 Nov 3;2014. pii: bcr2014205528. doi: 10.1136/bcr-2014-205528.

Research Trials

  1. ​The VICTORY (Virus-induced Cancer: Translational Oncology Research and Immunology)
  2. Gene expression profiling of early gastric cancer with lymph node metastasis by targeted RNA sequencing
  3. Global epigenetic analyses of both the tumour and its microenvironment and characterization of tumor-infiltrating leukocytes in Hepatocellular Carcinoma
  4. Intratumoral PD-L1 expression and Tumour infiltrating lymphocyte density in Oesophageal cancer treated with Neoadjuvant chemoradiation (PLuTON)
  5. Precision Medicine in Liver Cancer across an Asia-Pacific Network
  6. Effect of biopsy confirmed hepatic steatosis on development of Hepatocellular carcinoma in patients with chronic Hepatitis B