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Clin Prof Lee Lai Heng

Clin Prof Lee Lai Heng


Senior Consultant

Singapore General Hospital

Specialty: Haematology

Clinical Interest: Thrombosis and Haemostasis

Conditions Treated by this Doctor:
Acute Lymphocytic Leukemia (ALL), Aplastic Anaemia, Chronic lymphocytic leukemia, Chronic Myeloid Leukemia, Deep Vein Thrombosis, Deep Vein Thrombosis, Essential Thrombocythemia and Myelofibrosis, Haematology, Hemophilia, Multiple Myeloma, Myelodysplastic Syndrome, Myelofibrosis, Polycythemia Vera, Pulmonary Embolism, Thalassemia.

Clinical Appointments

  • Senior Consultant SingHealth Duke-NUS Blood Cancer Centre
  • Senior Consultant Haematology Singapore General HospitalSingapore General Hospital
  • Senior Consultant National Cancer Centre SingaporeNational Cancer Centre Singapore


Prof Lee received her medical and advanced specialist training in haematology in Singapore. She is currently a senior consultant with the Department of Haematology. She has an interest in Thrombosis and Haemostasis and played a key role in setting up the anticoagulation clinic and clinical trials in novel anticoagulants, promoting patient safety in anticoagulation therapy. Shehas helped refine the practice of anticoagulation monitoring services in this hospital. Her interest in haematology research, in particular clinical research in thrombotic and bleeding diseases has resulted in numerous publications in peer reviewed journals.

Prof Lee is also actively involved in medical education in her roles as Clinical Professor, Yong Loo Lin School of Medicine, NUS and Duke-NUS Medical School. Besides her clinical, administrative, and academic duties, Prof Lee also participates actively in the local and regional professional scenes with her roles as Chairman of the Asia Pacific Society of Thrombosis and Haemostasis, Chairperson of the Chapter of the Haematology (College of Physicians, Singapore), Elected executive member of College of Physicians and past President of the Singapore Society of Haematology.


Professional Appointments and Committee Memberships

  • Chairman, Residency Advisory Committee, Specialist Accreditation Board

  • Chairman, Chapter of Haematology, College of Physician, Singapore 

  • Honorary Secretary, College of Physician, Singapore

  • Chairman, Asia Pacific Society of Thrombosis and Haemostasis


  • SingHealth GCEO Excellence Awards – Outstanding Clinician Award 2016
  • Singapore Health Quality Service Award (SHQSA) Star Award 2016
  • Singapore General Hospital Long Service Award – 30 years Long Service Award 2016
  • Ministry of Health MOH Long Service Award – 15 year Long Service Award 2016
  • SingHealth Quality Service Award (SILVER Category) 2015
  • National Day Public Service Award – Long Service Award 2014
  • Singapore Health Quality Service Award – Star Award 2010
  • Excellent Service Award - Star Award 2008
  • Excellent Service Award - Gold Award 2007
  • Service Quality, Service with a heart award – 2005, 2007, 2008

Research Interests


  • Markers of thrombin and plasmin generation in patients with inherited thrombophilia. Lai Heng Lee, Ian Jennings, Roger Luddington, Trevor Baglin. Journal of Clinical Pathology 1994 47:631-634. 
  • Haemostasis associated with liver disease and liver transplantation. L H Lee , T Baglin. Annals, Academy of Medicine Singapore, 1994 Volume 23 No. 6 (Suppl) 77-83
  • Monoclonal Antibodies in the Treatment of Non-Hodgekin's Lymphoma. Lai H.Lee and Seah H. Lim. Clinical Immunotherapautics 2(2) 109-120, 1994 Adis  International
  • Altered Platelet phospholipid dependent thrombin generation in thrombocytopenia and Thrombocytosis. Lai Heng Lee, Trevor Baglin. British Journal of Haematology 1995, 89:131-136.
  • Haemophagocytosis in Bone Marrow Aspirate – A review of the Clinical Course of 10 Cases. Y.C.Linn, S.L.Tien, L.C. Lim, L.H. Lee, G. Teoh, Y.T. Goh, P. Tan. Acta, Haematology.   1995,94:182-191 
  • Exacerbation of Hepatitis in Hepatitis B carriers following chemotherapy for haematological malignancies. Wong Gee Chuan, Lee Lai Heng, Annals, Academy of Medicine Singapore 1996; 25:500-3
  • Low molecular weight heparin for thromboprophylaxis during pregnancy in 2 patients with mechanical mitral valve replacement. Lee L H, A Ng,  P Liaw. Thrombosis and Haemostsis 1996:76(4), 628-6293. 
  • Low Molecular Weight Heparins:  Indications and Use, Lai Heng Lee. Medical Progress (Adis International) 1997, 24(1):5-7
  • Pulmonary Embolism:  Diagnosis and Drug Treatment Lai Heng Lee, Wen Chang Ting. Medical Progress (Adis International) 1997, 24(7): 25-25
  • A Case Report of Neutrophilic Eccrine Hidradenitis in a Patient Receiving Chemotherapy for Acute Myeloid  leukaemia. C Wong, L H Lee, Y Y Chong Annals, Academy of Medicine Singapore, November 1998, Vol. 27 No. 6
  • A Study of Idiopathic Thrombocytopenic Purpura (ITP) Patients over a Ten-year Period. G C Wong, L H Lee. Ann Acad Med Singapore 1998; 27:789-93.
  • Activated Protein C Resistance: A Study among 60 Thromboembolic Patients in the Singapore Population. L C Lim, HH Tan, L H Lee, S L Tien, A Abdul Ghafar Annals Academy of Medicine Singapore 1999; 28:252-5
  • Thrombotic and haemorrhagic complications in patients with mechanical heart valve prosthesis attending the Singapore General Hospital Anticoagulation Clinic.  LH Lee, Annals. Academay of Medicine Singapore 2000; 29:71-4.
  • Myelodysplastic Syndrome with transformation to AML-M7 in a 46, XX male patient. Lai Ching Lau, Lai Heng Lee, William Hwang, Peng Lim, Weng-Onn Liu, Cance genetics and cytogenetics. 136(2002) 153-154.
  • Thrombin generation and fibrinolytic activities among patients receiving reduced-dose alteplase plus abciximab or undergoing direct angioplasty plus abciximab for acute myocardial infarction.
  • Lee LH, Nagarajan C, Tan CW, Ng HJ. Epidemiology of Cancer-Associated Thrombosis in Asia: A Systematic Review. Frontiers in cardiovascular medicine [Internet]. 2021;8:669288.
  • Lee LH, Gallus A, Jindal R, Wang C, Wu C-C. Incidence of Venous Thromboembolism in Asian Populations: A Systematic Review. Thrombosis and haemostasis [Internet]. 2017;117(12):2243–60.
    Ong SY, Tan CW, Ramya V, Malik AA, Lee XH, Hwang JCC, et al. Risk factors and predictors of treatment responses and complications in immune thrombocytopenia. Annals of hematology [Internet]. 2021 Mar;100(3):645–51.
  • Tan JY, Tan CW, Wong WH, Cheong MA, Lee LH, Kalimuddin S, et al. Post-hospitalization venous thromboembolism in COVID-19 patients: Evidence against routine post-hospitalization prophylactic anticoagulation. International journal of laboratory hematology [Internet]. 2021 Jun 19;
  • Tan TC, Goh CMY, Tan SSX, Tan LK, Yang Y, Lee LH. Epidemiology of pregnancy-associated pulmonary embolism in South Asian multi-ethnic country: Mortality trends over the last four decades. The journal of obstetrics and gynaecology research [Internet]. 2021 Jan;47(1):174–83.

Research Trials