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Assoc Prof Lee Haur Yueh

Assoc Prof Lee Haur Yueh

MBBS, MRCP (UK), M Med (Int Med), FAMS (Dermatology)

Head & Senior Consultant

Director, Allergy Centre

Singapore General Hospital

Specialty: Dermatology

Sub-specialties: Dermatology, Allergic Skin Disease, Autoimmune Skin Disease, Drug Allergy

Conditions Treated by this Doctor:
Atopic Dermatitis, Bullous Pemphigoid, Cutaneous Adverse Drug Reactions, Drug Hypersensitivity, Pemphigus, Stevens-Johnson Syndrome, Urticaria.

Clinical Appointments

  • Head & Senior Consultant Dermatology Singapore General HospitalSingapore General Hospital

Profile

Dr Lee graduated from the National Unviersity of Singapore and obtained his membership in the Royal College of Physicians in 2005.  He completed his specialty training in Dermatology in 2010.  

His subspecialty interests include cutaneous adverse drug reactions, autoimmune blistering diseases, and medical dermatology.  He has undergone further subspecialty in these areas at the Hopital Henri-Mondor, Assistance Publique-Hopitaux de Paris, France; Inselspital, Bern, Switzerland as well as King’s College Hospital, London, UK.

Education

  • MBBS, NUS
  • MRCP (UK)
  • M Med (Int Med)
  • FAMS (Dermatology)

Professional Appointments and Committee Memberships

  • Adjunct Associate Professor, Duke-NUS Medical School
  • Clinical Senior Lecturer, NUS Yong Loo Lin School of Medicine
  • Member, Residency Advisory Committee (Dermatology), MOH
  • President, Dermatological Society of Singapore 2019-2023

Awards

  • SGH Long service award (20 years) 2023
  • Public Administration Medal (Bronze) (COVID-19) 2023
  • Outstanding Faculty, Singhealth RISE Awards (2015)
  • SingHealth Publish! Award (2013,2014)
  • SingHealth HMDP award for fellowship in cutaneous adverse drug reactions, immunobullous dermatology and hospital dermatology (2010)
  • Top Candiate – Dermatology Exit Exam, Chapter of Dermatology (2010)
  • SingHealth Talent Development Grant Award (2008)

Research Interests

  • Severe cutaneous adverse reactions and drug hypersensitivity
  • Immunobullous disease
  • Atopic Dermatitis

Publications

  1. HL Ko, N Zhuo, ZW Chang …, HY Lee, EC Ren.  In-vitro vaccine challenge of PBMCS from BNT 162B2 anaphylaxis reveals HSP90A-NOD2-NLRP3 nexus.  Allergy 2023;78:304-7
  2. BSY Lian, JH Ha, R Sultana … HY Lee.  Systemic versus topical corticosteroids in the treatment of DRESS: A retrospective cohort study followed by a meta-analysis.  Am J Clin Dermatol 2023;24:637-47
  3. X Huan, N Zhuo, HY Lee, EC Ren. Allopurinol non-covalently facilittes binding of unconventional peptides to HLA-B*58:01.  Scientific Rep 2023;13:9373
  4. DAQ Oh, YW Yeo … HY Lee, KCL Choo.  Perceptions of teledermatology in the COVID-19 era: are patients ready for it?  Singapore Med J doi:10.4103/singaporemedj. SMJ – 2021-290
  5. WH Tan, J Sim, R Sultana, HY Lee. Rituximab in Subepidermal blistering diseases.  Dermatology 2023;239:5-11
  6. WH Tan, A Ho, HA Kadir, TK Zin, HCC Jordan, HY Lee .. Incidence of cutaneous graft-versus host disease in a Singapore academic medical centre – A retrospective cohort study.  Australas J of Dermatol 2023;64:e26-33
  7. CJ Chong, KJL Choo, KY Ong, V Tan.. HY Lee.  Improving drug allergy label accuracy by supervised safety and protocol driven evaluation.  Annals Acad Med Singapore 2022;51:677-85
  8. BSY Lian, KJL Choo, CJ Chong, IM Hanif, CS Naing, HY Lee. Injection site reactions after COVID-19 mRNA vaccination.  Annals Acad Med Singapore 2022;51:247-9
  9. HK Koh SMC, Fook-Chong, HY Lee.  Improvement of mortality prognosticiation in patients with epidermal necrolysis: The role of novel inflammatory makers and proposed revision of SCORTEN (Re-SCORTEN).  JAMA Dermatol 2022;158:160-66
  10. YCC Liew, KJL Choo, CC Oh, SM Pang, YW Yeo, HY Lee. Mycoplasma-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: Case-control analysis of a cohort managed in a specialized center.  J Am Acad Dermatol 2021; (epub 2021/4/26) PMID 33915240
  11. NKW Tan, DWT Yap, BKJ Tan, YW Teo, EHT Ker, JY Chan, HY Lee, A See, ST Toh.  The association of obstructive sleep apnea with melanoma incidence and mortality: a. meta-analysis of 5,276,45 patients.  Sleep Medicine 2021;88:213-220
  12. KJL Choo, AFW Ho, G Hao , PJM Tay, HY Lee et al. Relationship between local weather, air population and hospital attendances for urticaria in children: Time stratified analysis of 12,002 cases.  Clin Exp Allergy 2022;52:180-2
  13. AE Clark, S Fook-Chong, K Choo, CC Oh, YW Yeo, SM Pang, HY Lee.  Delayed admission to a specialist referral centre for Stevens-Johnson syndrome and toxic epidermal necrolysis is associated with increased mortaliy: A retrospective cohort study.  JAAD Int 2021;4:10-12
  14. WH Tan, CH Loh, ZT Chai, DAQ Ohm CC Oh, YW Yeo, KJL Choo, HY Lee. Early experience of inpatient teledermatology in Singapore during COVID-19. Ann Acad Med Sing 2021;50:487-9 
  15. SYB Lian CC Oh, YW Yeo, HY Lee. Spectrum of nail sequelae in Stevens-Johnson syndrome and toxic epidermal necrolysis. JAMA Dermatol 2021;157:117-9 
  16. DAQ Oh, YW Yeo, KJL Choo, SM Pang, CC Oh, HY Lee. Acute generalized exanthematous pustulosis: Epidemiology, clinical course and treatment outcomes of patients treated in an Asian academic medical centre.  JAAD Int 2021 doi.org/10.1016/j.jdin.2020.12.004
  17. HK Koh, Fook-Chong S, HY Lee.  Assessment and Comparison of Performance of ABCD-10 and SCORTEN in prognostication of epidermal necrolysis.  JAMA Derm 2020. Doi.10.1001/jamadermatol.2020.3654.
  18. LC Heng, YW Phoon, SM Pang, HY Lee.  Pemphigoid and pemphigus: Comparative analysis of clinical epidemiology course and outcome in an Asian Academic Medical Centre.  Austral J Dermatol 2020
  19. ZT Chai, C Tan MMQ Liau, H Kaur, SM Pang, YW Phoon, NS Chandran, HY Lee.  Diabetes mellitus and hyperglycemic complications  in bullous pemphigoid.  J Am Acad Dermatol 2020;82:1234-7
  20. HK Koh, ZT Chai, HW Tay et al.  Risk factors and diagnostic markers of bacteremia in Stevens-Johnson syndrome and toxic epidermal necrolysis: A cohort study of 176 patients. J Am Acad Dermatol 2019;81:686-93
  21. Wang YH, Chen CB, Tassaneeyakul W, Saito Y, Choon SE, Lee HY, Chang M, Roa F et al.  The medication risk of Stevens-Johnson syndrome and Toxic Epidermal Necrolysis in Asians: the Major Drug Causality and Comparison to the USA FDA label.  Clin Pharmacol Ther 2019;105:112-20

Book Chapters 
Ardern-Jones M, Lee HY.  Benign cutaneous adverse drug reactions to drugs. Chapter 118  Rook’s Textbook of Dermatology, 9th Edition, (Eds:  Griffith C, Barker J, Bleiker T, Chalmers R, Creamer D); Wiley 2016

Walsh S, Lee HY, Creamer D.  Severe cutaneous adverse drug reactions to drugs. Chapter 119. Rook’s Textbook of Dermatology, 9th Edition, (Eds:  Griffith C, Barker J, Bleiker T, Chalmers R, Creamer D); Wiley 2016 

Walsh S, Lee HY, Creamer D. Cutaneous adverse reactions to drugs. 6th edition, Oxford Textbook of Medicine (Eds Firth J, Conlon C, Cox T); Oxford University Press, 2020

Research Trials