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Clin Assoc Prof Ang Ai Leen

Clin Assoc Prof Ang Ai Leen


Senior Consultant

Singapore General Hospital

Specialty: Haematology

Sub-specialties: Transfusion Medicine, Red Cell Disorders

Conditions Treated by this Doctor:
Acute Lymphocytic Leukemia (ALL), Aplastic Anaemia, Chronic lymphocytic leukemia, Chronic Myeloid Leukemia (CML), Deep Vein Thrombosis, Deep Vein Thrombosis, essential thrombocythemia, Multiple Myeloma, Myelodysplastic Syndromes, Myelofibrosis, Polycythemia Vera, Pulmonary Embolism, Thalassaemia.

Clinical Appointments

  • Senior Consultant SingHealth Duke-NUS Blood Cancer Centre
  • Senior Consultant Haematology Singapore General HospitalSingapore General Hospital

Academic Appointments

  • Clinical Associate Professor, Duke-NUS Graduate Medical School Singapore


Dr Ang Ai Leen received her medical education at the National University of Singapore. After graduation in 2001, she continued to receive her Basic Specialist Training (Internal medicine) from 2002-2005 and Advanced Specialist Training (Haematology) from 2005-2008 in Singapore. She is currently a Senior Consultant at the Department of Haematology, Singapore General Hospital. Dr Ang has subspecialty training in red cell disorders and transfusion medicine. She is the lead of the Red Cell Service, Department of Haematology, Singapore General Hospital. 

Concurrent to her hospital appointment, Dr Ang is also the Group Director of the Blood Services Group, Health Sciences Authority, Singapore. In this capacity, Dr Ang oversees the blood transfusion program for the nation. 


  • MBBS (NUS, Singapore) 2001
  • MRCP (UK) (RCP, United Kingdom) 2005
  • FRC Path (RCPath, United Kingdom) 2009

Professional Appointments and Committee Memberships

  • Clinical Associate Professor, Duke-NUS Graduate Medical School Singapore
  • Senior Clinical Lecturer for Yong Loo Lin School of Medicine, National University of Singapore


Research Interests


  • Ang AL, Lim CY, Ng WY, Lam JCM. Non-transfusion dependent thalassemia is independently associated with higher alloimmunization risk than transfusion dependent thalassemia and would benefit the most from extended red cell antigen-matching. Transfusion. 2021 Sep; 61(9): 2566–77.
  • Al-Riyami AZ, Burnouf T, Yazer M, Triulzi D, Kumaş LT, Sağdur L, et al. International Forum on the Collection and Use of COVID-19 Convalescent Plasma: Responses. Vox Sang. 2021 Nov; 116(10): e71–120.
  • Lam JCM, Lee SY, Koh PL, Fong SZ, Abdul-Kadir NI, Lim CY, et al. Clinical and health-related quality of life outcomes of transfusion-dependent thalassaemia patients in Singapore. Blood Cells Mol Dis. 2021 May; 88: 102547. 
  • Bloch EM, Goel R, Wendel S, Burnouf T, Al-Riyami AZ, Ang AL, et al. Guidance for the procurement of COVID-19 convalescent plasma: differences between high- and low-middle-income countries. Vox Sang. 2021 Jan; 116(1): 18–35. 
  • Abdullah HR, Ang AL, Froessler B, Hofmann A, Jang JH, Kim YW, et al. Getting patient blood management Pillar 1 right in the Asia-Pacific: a call for action. Singapore Med J. 2020 Jun; 61(6): 287–96. 
  • Ang AL, Wong WH, Tan J, Ng HJ, Tan CW, Kuperan P, et al. Ex vivo haemostatic capacity of plasma upon thawing and beyond: a comparison between fresh frozen plasma (FFP) and frozen plasma prepared from whole blood stored at room temperature up to 24 hours postcollection (RTFP24). Vox Sang. 2019 Apr; 114(3): 198–206.
  • Tan CW, Wong WH, Idros R, Chan YH, Kaur H, Tng ARK, et al. Role of platelets in thrombin generation amongst patients with non-transfusion-dependent thalassaemia. Ann Hematol. 2019 Apr; 98(4): 861–8. 
  • Seed CR, Allain J-P, Lozano M, Laperche S, Gallian P, Gross S, et al. International Forum on Occult hepatitis B infection and transfusion safety. Vox Sang. 2019 May; 114(4): e1–35.
  • Chen Y, Law HY, Tan GP, Ang AL. Concurrent β-thalassaemia trait and Southeast Asian ovalocytosis associated with clinically significant iron loading. Vol. 63, Blood cells Mol Dis. 2017 Mar; 63: 25–6.
  • Sim YE, Wee HE, Ang AL, Ranjakunalan N, Ong BC, Abdullah HR. Prevalence of preoperative anemia, abnormal mean corpuscular volume and red cell distribution width among surgical patients in Singapore, and their influence on one year mortality. PLoS One. 2017; 12(8): e0182543.
  • Ang AL, Le TT, Tan RS. HbH Constant Spring disease has lower serum ferritin relative to liver iron concentration (LIC): importance of LIC measurement and potential impact on serum ferritin thresholds for iron chelation. Vol. 176, Br J Haematol. 2017 Mar: 176(6): 986–8.
  • Chay J, Koh M, Tan HH, Ng J, Ng HJ, Chia N, et al. A national common massive transfusion protocol (MTP) is a feasible and advantageous option for centralized blood services and hospitals. Vox Sang. 2016 Jan; 110(1): 36-50.
  • Tzoulis P, Ang AL, Shah FT, Berovic M, Prescott E, Jones R, et al. Prevalence of low bone mass and vitamin D deficiency in β-thalassemia major. Hemoglobin. 2014; 38(3): 173–8.
  • Ang AL, Tzoulis P, Prescott E, Davis BA, Barnard M, Shah FT. History of myocardial iron loading is a strong risk factor for diabetes mellitus and hypogonadism in adults with β thalassemia major. Eur J Haematol. 2014 Mar; 92(3): 229–36.
  • Bawazir WM, Gevers EF, Flatt JF, Ang AL, Jacobs B, Oren C, et al. An infant with pseudohyperkalemia, hemolysis, and seizures: cation-leaky GLUT1-deficiency syndrome due to a SLC2A1 mutation. J Clin Endocrinol Metab. 2012 Jun; 97(6):E987-93.
  • Ang A L, Linn Y C. Treatment of severe neutropenic sepsis with granulocyte transfusion in the current era– experience from an adult Haematology unit in Singapore. Transfus Med. 2011 Feb; 21(1): 13-24.
  • Ang AL, Kuperan P, Ng CH, Ng HJ. Acquired factor V inhibitor. A problem-based systematic review. Thromb Haemost. 2009 May; 101(5) :852–9.
  • Ang A L, Teo D, Lim C H, Leou K K, Tien S L, Koh M B C. Blood transfusion requirements and independent predictors of increased transfusion requirements among adult patients on extracorporeal membrane oxygenation – a single centre experience. Vox sang. 2009 Jan; 96(1): 34-43.

Research Trials