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Research

(1) General Nephrology and Glomerulonephritis 

The research group builds upon a long history of research by Emeritus Prof Woo Keng Thye in the field of IgA nephropathy. Our research fields include molecular markers predicting the progress of Chronic Kidney Diseases. Our projects are sponsored by National Kidney Foundation, and other grant agents. We collaborate with researchers from A*STAR, Duke-NUS in these research projects. Our findings on IgA nephropathy include impact of Renin-Angiotensin system gene polymorphism as well as single nucleotide polymorphisms in the progression of IgA nephropathy towards End stage renal disease. Our findings are published in journals including Kidney International, PLOS One, Clinical Kidney Journal and others.

The department has multiple clinical trials with pharma at different trial phases. The department works closely with the clinical trial research center (CTRC) as well as the investigative medical unit (IMU). The department has a research lab that caters for clinician initiated investigative trials and is able to do molecular and genetic work. 

(2) Critical Care Nephrology 

Our Critical Care Nephrology research team focuses on risk factors associated to the patients under critical care.  One of our projects is “Biodegradeable Stents for Hemodialysis Vascular Access Interventions”, funded by National Kidney Foundation. The research results are published on Nephrology, Cardiorenal Medicine etc.

(3) Hemodialysis and Peritoneal Dialysis 

Our dialysis research teams mainly focus on improvement of vascular access, prolonging access survival and reduce technique failure through experimental and devices trials. Our projects include developing “Automated Wearable Artificial Kidney Peritoneal Dialysis (AWAK PD) in the Treatment of End-Stage Renal Disease (ESRD) Patients”, “Novel Hole Access Device to Preserve Vascular Access and Reduce Cost for Hemodialysis”.  The research projects are sponsored by Ministry of Health, National Kidney Foundation, A*STAR and other resources. Our collaborators include researchers from A*STAR and other hospitals. Our findings are published in distinguished Journals, such as Hemodialysis International, Kidney International, American Journal of Kidney Diseases, International Urology and Nephrology, Nephrology and others.

(4) Kidney Transplantation

Being the largest pioneer transplant center in the country, the department has ongoing research on mechanism of immunosuppression working with pharmacists and other discipline. Our current projects include “Clinical and Psychosocial Impact of Living Kidney Donation in Singapore” “Effects Of CYP3 Genotypes in Kidney Transplant recipients”. These projects are sponsored by National Kidney Foundation, Lee Foundation etc. The transplant program is also involved in clinical trials on optimizing immunosuppression and is active in in quality improvement projects. Our findings are published on journals including Am J Transplant, Journal of Transplantation, and Asia Pacific Family Medicine etc.