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Tegafur/Uracil (UFT® )

Drug Class: Commonly Known As: Category:
Antimetabolite UFT® Cancer-related

Tegafur/Uracil (UFT® ) - What is it for

UFT® is a combination oral chemotherapy used to treat certain types of cancer e.g. head and neck, colorectal, gastric, liver, gallbladder or bile duct, pancreatic, lung, breast, bladder, prostate and uterine cervical cancers.

Tegafur/Uracil (UFT® ) - Side Effects, Precautions, and Contraindications

What side effects can Tegafur/Uracil (UFT® ) cause?

  • Nausea and vomiting
  • Loss of appetite, mouth sores
  • Diarrhea and/or abdominal pain
  • Decreased white and red blood cells, platelets
    This may increase your chances of getting infections, bruising or bleeding and feeling tired. Your doctor will schedule blood tests for you as needed.

Inform your doctor if any of the following occurs:

  • Fever of 38˚C or higher
  • Unusual bleeding, bruising or black sticky stools
  • Severe diarrhea and/or abdominal pain
  • Yellowing of the skin or eye whites, dark tea-colored urine
  • Chest pain or shortness of breath
  • Skin rash or itch

Before taking Tegafur/Uracil (UFT® ), what precautions must I follow?

  • Use effective birth control during treatment and for 3 months after stopping UFT®. Inform your doctor if you or your partner plan for or suspect pregnancy.
  • Inform your doctor or pharmacist if you have any other medical conditions e.g. heart problems.

What food or medicine must I avoid when I take Tegafur/Uracil (UFT® )?

Tegafur/Uracil (UFT® ) - Dosage and How to Use

How should Tegafur/Uracil (UFT® ) be used?

​It is a capsule taken by mouth and swallowed whole with water. Take at least 1 hour before or 1 hour after food.

The dose given is based on your body weight and height. Take the exact number of capsules and follow the dosing schedule instructed by your doctor.

What should I do if I miss a dose?

​If you miss a dose of UFT®, take it as soon as you can. If it is almost time for the next dose, skip the missed dose and go back to your usual dosing times. Do not double dose.

What should I do if I overdose?

​If you overdose on this medication, inform your doctor immediately.

Tegafur/Uracil (UFT® ) - Handling

How should I handle Tegafur/Uracil (UFT® ) safely?

Tegafur/Uracil (UFT® ) - Storage

How should I store Tegafur/Uracil (UFT® )?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#Store at room temperature;#

How should I dispose of Tegafur/Uracil (UFT® ) safely?

Tegafur/Uracil (UFT® ) - Additional Information

  • Updated on Monday, March 4, 2019
  • Article contributed by Department of Pharmacy National Cancer Centre Singapore

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