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T-DM1 (Trastuzumab emtansine)

Drug Class: Commonly Known As: Category:
Anti-HER2 Antibody Drug Conjugate Kadcyla® Cancer-related

T-DM1 (Trastuzumab emtansine) - What is it for

​T-DM1 is a drug that is used to treat breast cancer. It consists of an antibody (trastuzumab) and a chemotherapy drug called DM1 (also known as emtansine) linked together. The antibody helps deliver DM1 more specifically to cancer cells, to fight against them.  

T-DM1 (Trastuzumab emtansine) - Side Effects, Precautions, and Contraindications

What side effects can T-DM1 (Trastuzumab emtansine) cause?

During infusion

  • Development of itch, rashes, fever, chills and rigors, difficulty breathing
  • Redness pain or swelling at the injection site

Please alert your nurse if you experience any of the above symptoms during the infusion.

Possible side effects

  • Fatigue or muscle ache
  • Numbness and tingling in your feet or hands
  • Constipation or diarrhea
  • Decrease in the number of blood cells
    This may put you at a higher risk of infections, bleeding or bruising.

Please seek medical attention if any of the following occurs:

  • Signs of liver toxicity e.g. severe abdominal pain, tea-coloured urine, yellowing of the skin or whites of eyes
  • Unusual bleeding, bruising or black tarry stools
  • Fever of 38°C or higher
  • Shortness of breath, worsening or persistent dry cough
  • Abnormal chest pain, irregular heartbeat or persistent swelling of lower legs

Before taking T-DM1 (Trastuzumab emtansine), what precautions must I follow?

What food or medicine must I avoid when I take T-DM1 (Trastuzumab emtansine)?

T-DM1 (Trastuzumab emtansine) - Dosage and How to Use

How should T-DM1 (Trastuzumab emtansine) be used?

What should I do if I miss a dose?

What should I do if I overdose?

T-DM1 (Trastuzumab emtansine) - Handling

How should I handle T-DM1 (Trastuzumab emtansine) safely?

T-DM1 (Trastuzumab emtansine) - Storage

How should I store T-DM1 (Trastuzumab emtansine)?

How should I dispose of T-DM1 (Trastuzumab emtansine) safely?

T-DM1 (Trastuzumab emtansine) - Additional Information

  • Updated on Thursday, October 25, 2018
  • Article contributed by Department of Pharmacy National Cancer Centre Singapore

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