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Sirolimus

Drug Class: Commonly Known As: Category:
mTOR Kinase Inhibitor Rapamune® Cancer-related, Children, Adult

Sirolimus - What is it for

Sirolimus is a medicine that suppresses the immune system. It is used to treat certain types of cancer.

It is also used to treat vascular malformations, which are abnormalities in the development of blood vessels. These malformations vary in size and location within the body.

Sirolimus - Side Effects, Precautions, and Contraindications

What side effects can Sirolimus cause?

  • Nausea and/or vomiting may sometimes occur when you first start taking Sirolimus
  • Acne
  • Mild to moderate headache
  • Slight indigestion or diarrhea may sometimes occur
  • Increased cholesterol or lipid levels
    Your blood cholesterol should be monitored regularly. Discuss a proper follow-up plan with your doctor.
  • Body aches and tiredness on some days.
    Try to avoid heavy-duty work or long outings on such days.

Inform your doctor if you experience any of the following:

  • Allergic reactions – rashes, swelling, breathing difficulty
  • Rapid heartbeat or chest pain
  • Signs of infection – fever or chills, cough, sore throat, pain or difficulty in urinating
  • Signs of bleeding – bruising, black tarry stools, blood in the urine
  • Unusual weakness, tiredness or light-headedness

Before taking Sirolimus , what precautions must I follow?

  • ​Use effective birth control before treatment, during treatment and for at least 12 weeks after stopping treatment.
  • Do not take medicines and supplements without first informing your doctor and pharmacist.
  • Avoid going to crowded places or being near sick people to minimize your risk of getting an infection.

What food or medicine must I avoid when I take Sirolimus ?

​Avoid grapefruit and its juice while you are on Sirolimus.

Sirolimus - Dosage and How to Use

How should Sirolimus be used?

​It is a tablet taken by mouth, with a glass of plain water. It should be taken consistently with or without food. Take the exact number of tablets instructed by your doctor.

What should I do if I miss a dose?

​If you miss a dose of Sirolimus, take it as soon as you remember. If it is too near your next dose, skip the missed dose and go back to your usual dosing. Do not double the dose.

What should I do if I overdose?

​If you overdose on this medicine, inform your doctor immediately.

Sirolimus - Handling

How should I handle Sirolimus safely?

Do not break or crush the tablets.

Sirolimus - Storage

How should I store Sirolimus ?

;#Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#Store at room temperature;#

How should I dispose of Sirolimus safely?

Sirolimus - Additional Information

  • Updated on 6/6/2018 12:00:00 AM
  • Article contributed by Department of Pharmacy National Cancer Centre Singapore
The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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