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Posaconazole

Drug Class: Commonly Known As: Category:
Antifungal Noxafil Children, Adult, Cancer-related

Posaconazole - What is it for

Posaconazole is an antifungal medication used to prevent or treat fungal infections.

Posaconazole - Side Effects, Precautions, and Contraindications

What side effects can Posaconazole cause?

Some of the common side effects of posaconazole include

  • Stomach discomfort, nausea and vomiting, diarrhea and constipation
  • Low potassium , calcium and magnesium levels resulting in muscle pain and weakness
  • Headache, dizziness or drowsiness.

Please inform your doctor if you experience any other side effects or if the side effects become severe and bothersome.

There are some potentially serious, but less common side effects that may be experienced. If they occur, seek medical attention immediately:

  • Rash and other signs of allergic reactions such as tightness in the chest or throat, trouble breathing, swelling in the mouth, face or lips.
  • Signs of liver problems like dark urine, feeling tired, inability to eat a full meal or feeling full after only a small amount of food, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Fast heartbeat, a heartbeat that does not feel normal, or passing out.

Before taking Posaconazole, what precautions must I follow?

What food or medicine must I avoid when I take Posaconazole?

Before starting posaconazole, do inform your doctor of any other medications that you are already on.

Do not take/give any other medications or herbal products without consulting your doctor or pharmacist. Some medication or food may reduce its efficacy, or increase the incidence of side effects where close monitoring is required. Posaconazole may also increase the side effects of other medications such as cholesterol medications and immunosuppressants. You may also need to avoid antacids or medications that may reduce acidity of the stomach.

Posaconazole - Dosage and How to Use

How should Posaconazole be used?

Posaconazole can be taken once to four times daily. The doctor may change the dosage of posaconazole depending on blood tests results. Always follow the doctor's instructions strictly.

Suspension

  • Take this drug with or within 20 minutes of a full meal. You may be advised to take with a high fat meal ( e.g peanut butter) by your doctor/pharmacist.
  • If you are not able to eat a full meal, take this drug with a liquid nutrition supplement or an acidic carbonated drink like cola. If you are not able to drink these drinks, talk with the doctor.
  • Shake well before use.

Tablet

  • Take this drug with food.
  • Swallow whole. Do not chew, break, or crush.
  • If there is trouble swallowing, talk with the doctor.

Do not switch between taking posaconazole tablets and oral suspension without talking to your doctor or pharmacist because it may result in a lack of efficacy or an increased risk of adverse reactions.

What should I do if I miss a dose?

Suspension :

If you forget a dose , take it as soon as you remember. If it is nearer to the time of your next dose,skip the missed dose. Do not take two doses at the same time

Tablet :

If it is 12 hours or more after scheduled dosing, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or exta doses

What should I do if I overdose?

Posaconazole - Handling

How should I handle Posaconazole safely?

Posaconazole - Storage

How should I store Posaconazole?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

Store at room temperature, in a cool dry place. Do not freeze.

For suspension, it may be kept up to the expiry on the bottle after opening.

How should I dispose of Posaconazole safely?

Posaconazole - Additional Information

​Do not use this medicine if you are allergic to posaconazole.  Before starting posaconazole, do inform your doctor of any other medications that you are already on. 

Do not take during pregnancy. Effective contraception is advised in females of childbearing potential.

  • Updated on Friday, September 21, 2018
  • Article contributed by Pharmacy Department KK Women's and Children's Hospital

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