Dr Timothy Tay

MBBS, FRCPA, FRCPath

Senior Consultant

Singapore General Hospital

Specialty: Pathology

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About

Education and Training

Awards

Publications

Clinical Interests

Anatomical Pathology, Bone ＆ Soft Tissue Pathology, Bone ＆ Soft Tissue Pathology, Breast Pathology, Breast Pathology

Clinical Appointments

Senior Consultant

Anatomical Pathology

Academic Appointments

Clinical Assistant Professor, Duke-NUS Medical School

Vice Chair (Strategic Programme), Pathology Academic Clinical Programme, SingHealth Duke-NUS Academic Medical Centre

About

Timothy graduated from Yong Loo Lin School of Medicine, National University of Singapore and did his postgraduate residency training in Anatomical Pathology. Having completed his fellowship exams, he is a Fellow of both The Royal College of Pathologists (United Kingdom) as well as The Royal College of Pathologists of Australasia. He has a special interest in Breast, Bone and Soft Tissue and Molecular Pathology and was awarded the SingHealth Health Manpower Development Plan (HMDP) Fellowship to pursue further training at the Memorial Sloan Kettering Cancer Centre in New York, USA as well as Institute of Pathology, Heidelberg University Hospital, Germany. Timothy currently holds a Senior Consultant position at the Singapore General Hospital Department of Anatomical Pathology within which he also heads the Anatomical Molecular Laboratory (former Translational Pathology Centre).

Education and Training

Fellow of The Royal College of Pathologists of Australasia (FRCPA)
Fellow of The Royal College of Pathologists (FRCPath)(UK)
Bachelor of Medicine, Bachelor of Surgery (MBBS)(S'pore)

Awards

Outstanding Faculty Award (SingHealth Pathology Residency)
Outstanding Resident Award (SingHealth Pathology Residency)
Service with a Heart Award (Singapore General Hospital)
Meritorious House Officer Award (National University of Singapore)

Publications

Selected publications

Tay TKY, Tan GS, Lee SH, Sam XX, Lim TH, Ng JWK, Tan DSW, Lim TKH. Comparison of an amplicon-based large panel next generation sequencing (NGS) assay with conventional testing methods for MET and HER2 amplification in lung and breast cancers. Pathology. 2024;56:325-333.
Tan JSH, Tay TKY, …, Ang MK. Combinatorial Hypofractionated Radiotherapy and Pembrolizumab in Anaplastic Thyroid Cancer. Eur Thyroid J. 2024 Jan 1;13(1):e230144.
Seker-Cin H, Tay TKY, …, Stenzinger A, Volckmar A. Analysis of rare fusions in NSCLC: Genomic architecture and clinical implications. Lung Cancer. 2023:184:107317.
Tan-Garcia A, Tay TKY, Shi R, Yeo SJ, Sittampalam K. A hyalinised tenosynovial giant cell tumour with absence of giant cells posing a diagnostic challenge. Pathology. 2023;55:726-728.
Tan TJ, Fink JL, Tay TKY, Jaradi B, Stone N, Waring P, Koo KM, Tan PH, Tan DS, Dent RA. Exquisitely Platinum-Sensitive Triple-Negative Breast Cancer, Time for BRCA Methylation Testing? JCO Precis Oncol. 2022;6:e2200309.
Tay TKY, Yeong JPS, Chen EX, Sam XX, Lim JX, Chan JY. Soft Tissue Leiomyosarcoma With Microsatellite Instability, High Tumor Mutational Burden, and Programmed Death Ligand-1 Expression Showing Pathologic Complete Response to Pembrolizumab: A Case Report. JCO Precis Oncol. 2022;6:e2200068.
Seow DYB, Tay TKY, Tan PH. Fibroepithelial lesions of the breast: A review of recurring diagnostic issues. Semin Diagn Pathol. 2022;39:333-343.
Ferguson DC, Mata DA, Tay TKY, Traina TA, Gucalp A, Chandarlapaty S, D'Alfonso TM, Brogi E, Mullaney K, Ladanyi M, Arcila ME, Benayed R, Ross DS. Androgen receptor splice variant-7 in breast cancer: clinical and pathologic correlations. Mod Pathol. 2022;35:396-402.
Linn YL, Tay TKY, Tan EH, Wong JSL, Madhukumar P. Breast metastasis presenting as swelling with calcification - A case report and review of the literature. Breast Dis. 2022;41:151-154.
Tay TKY, Sukma NB, Lim TH, Kuick CH, Goh JY, Chang KTE. Correlating SS18-SSX immunohistochemistry (IHC) with SS18 fluorescent in situ hybridization (FISH) in synovial sarcomas: a study of 36 cases. Virchows Arch. 2021;479:785-793.
Tay TKY, Tan PH. Papillary neoplasms of the breast – reviewing the spectrum. Mod Pathol. 2021;34:1044-1061.
Tay TKY, Tan PH. Liquid Biopsy in Breast Cancer: A Focused Review. Arch Pathol Lab Med. 2021;145:678-686.
Chan JYS, …, Tay TKY, …, Soo KC. Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma. J Clin Invest. 2020;130:5833-5846.
Zhao Z, Tay TKY, Agrawal R, Tan VKM, Tan YY, Tan PH. Intraepidermal malignancy in breast skin: A tale of two tumours. Human Pathology: Case Reports. 2018 Nov;14:33-7.
Tay TKY, Guan P, Loke BN, Nasir NDM, Rajasegaran V, Thike AA, Lian D, Chang KTE, Teh BT, Ng CCY, Tan PH. Molecular insights into paediatric breast fibroepithelial tumours. Histopathology. 2018;73:809-818.
Tay TKY, Thike AA, Pathmanathan N, Jara-Lazaro AR, Iqbal J, Sng ASH, Heng SY, Lim JCT, Koh VCY, Tan JSY, Yeong JPS, Chow ZL, Li HH, Cheng CL, Tan PH. Using computer assisted image analysis to determine the optimal Ki67 threshold for predicting outcome of invasive breast cancer. Oncotarget. 2018; 9:11619–11630.
Tay TKY, Kuick CH, Lim TH, Chang KTE, Sittampalam KS. A case of low grade fibromyxoid sarcoma with dedifferentiation. Pathology. 2018;50:348-351.
Tay TKY, Tan PH. Spindle cell lesions of the breast - An approach to diagnosis. Semin Diagn Pathol. 2017;34:400-409.
Tay TKY, Lim KL, Hilmy MH, Thike AA, Goh ST, Song LH, Hwang JSG, Mantoo S. Comparison of the sensitivity and specificity of p16/Ki-67 dual staining and HPV DNA testing of abnormal cervical cytology in the detection of histology proven cervical intraepithelial neoplasia grade 2 and above (CIN 2+). Malays J Pathol. 2017;39:257-265.
Tay TK, Chang KT, Thike AA, Tan PH. Paediatric fibroepithelial lesions revisited: pathological insights. J Clin Pathol. 2015;68:633-41.
Tay T, Wong SB, Sittampalam KS, Lie DT. Clear cell chondrosarcoma with secondary aneurysmal bone cyst changes. Singapore Med J. 2014 Mar;55(3):e49-51.
Wong KM, Tay TK, Poh WT, Taneja R. Solitary necrotic nodule of the liver: radiologic-pathologic correlation in a case with unusual imaging features. Jpn J Radiol (2013) 31:277-281.