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Neuro-Oncology Research

The team utilizes Dynamic Contrast Enhanced (DCE) MR perfusion, H1 MR spectroscopy, diffusion imaging and lipid imaging to study focal brain and spinal lesions. The higher-grade angiogenic tumours have hallmarks of increased number of microvessels and irregular branching with poorly formed endothelial walls, contributing to microvascular hyperpermeability. The SGH team collaborates with the NCC Oncologic Imaging Team on the use of distributed parameter model in DCE-MRI to interrogate tumour leakiness which allows for quantification of more perfusion parameters. We also integrate other MRI techniques as adjunct to provide additional information on the tumour characteristics such as diffusion imaging to reflect tumour cellularity and vascularity, and magnetic resonance spectroscopy (MRS) that provide additional information on neurometabolite concentrations. On top of that, lipid metabolism change has unexplored potentials for the characterisation of tumours given the important role of lipid in cancer metabolism and tumour development. In-and opposed-phase is a simple alternative to lipid quantification which reflects lipid metabolic change other than MRS.

Brain tumor patient with a non-specific enhancing right occipital lesion (a-d) delineated on (a) post-contrast T1-weighted and (b) T2 FLAIR images, demonstrating low and high signal on the (c) v1 (ratio of blood plasma volume to tissue volume) and (d) v2 (ratio of extra-vascular extracellular space volume to tissue volume) maps of dynamic contrast-enhanced (DCE) scan favouring post treatment change.


Please contact the team consisting of Dr Lim Kheng Choon, Dr Septian Hartono and Dr Seow Poh Choo for more information.


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